CD8+ but Not CD4+ T Cells Require Cognate Interactions with Target Tissues To Mediate GVHD across Only Minor H Antigens but CD4+ and CD8+ T Cells Both Require Direct Leukemic Contact for GVL.
Shlomchik W, Matte C, Liu J, Jain D, McNiff J. CD8+ but Not CD4+ T Cells Require Cognate Interactions with Target Tissues To Mediate GVHD across Only Minor H Antigens but CD4+ and CD8+ T Cells Both Require Direct Leukemic Contact for GVL. Blood 2005, 106: 580. DOI: 10.1182/blood.v106.11.580.580.Peer-Reviewed Original ResearchCD8-mediated GVHDDirect cognate interactionT cellsSecond transplantCD4 cellsCD8 cellsHost antigensCognate interactionMHCII expressionBone marrowDonor CD4 cellsDonor-derived APCsT-cell releaseTarget tissuesAlloreactive T cellsBone marrow chimerasMinor H antigensCognate T cellsChimeric recipientsDonor BMGVHD lethalityHistologic GVHDHost APCsLess GVHDLeukemic expression