2023
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Islam F, McNiff J, Craft J. HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. JCI Insight 2023, 8: e166076. PMID: 37526979, PMCID: PMC10543720, DOI: 10.1172/jci.insight.166076.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusLupus skin diseaseT cellsSkin diseasesCytotoxic signatureInflammatory infiltrateHIF-1Tissue damageKidney-infiltrating T cellsSkin-infiltrating T cellsAutoimmune skin diseaseHIF-1 inhibitionSkin tissue damageLupus erythematosusSystemic diseaseTissue inflammationGranzyme BMouse modelInflammatory gene programDiseaseProtein levelsInfiltratesSkin environmentGene programPresent study
2021
Cytokine RNA In Situ Hybridization Permits Individualized Molecular Phenotyping in Biopsies of Psoriasis and Atopic Dermatitis
Wang A, Fogel AL, Murphy MJ, Panse G, McGeary MK, McNiff JM, Bosenberg M, Vesely MD, Cohen JM, Ko CJ, King BA, Damsky W. Cytokine RNA In Situ Hybridization Permits Individualized Molecular Phenotyping in Biopsies of Psoriasis and Atopic Dermatitis. JID Innovations 2021, 1: 100021. PMID: 34909719, PMCID: PMC8659380, DOI: 10.1016/j.xjidi.2021.100021.Peer-Reviewed Original ResearchAtopic dermatitisAtopic dermatitis casesInflammatory skin diseaseInflammatory skin disorderSubset of casesSitu hybridizationCytokine RNARoutine biopsyCytokine expressionPredominant cytokinePsoriasis casesCytokine targetsTreatment selectionDermatitis casesSkin disordersPsoriasis biomarkersSkin diseasesIndividual cytokinesIndividualized evaluationPsoriasisBiopsyBulk RNA sequencingCytokinesMolecular phenotypingPatients
2001
Pathogenesis of autoimmunity in αβ T cell-deficient lupus-prone mice
Peng S, Cappadona J, Mcniff J, Madaio M, Owen M, Hayday A, Craft J. Pathogenesis of autoimmunity in αβ T cell-deficient lupus-prone mice. Clinical & Experimental Immunology 2001, 111: 107-116. PMID: 9472669, PMCID: PMC1904839, DOI: 10.1046/j.1365-2249.1998.00424.x.Peer-Reviewed Original ResearchConceptsT cell-dependent mechanismCell-dependent mechanismEnd-organ diseaseImmune complex depositionGammadelta T cellsRenal diseaseMurine lupusComplex depositionT cellsMRL miceSkin lesionsComplement fixationT-cell-deficient animalsEnd-organ damageLupus-prone miceNon-autoimmune micePathogenesis of autoimmunityYears of ageHumoral autoimmunityLupus lesionsAutoantibody productionSkin diseasesSkin injuryTCR alphaFas antigenDeficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level
Chan O, Paliwal V, McNiff J, Park S, Bendelac A, Shlomchik M. Deficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level. The Journal Of Immunology 2001, 167: 2985-2990. PMID: 11509649, DOI: 10.4049/jimmunol.167.5.2985.Peer-Reviewed Original ResearchConceptsSkin diseasesT cell-dependent mechanismMRL/lpr miceLupus skin diseaseLupus skin lesionsMRL-Faslpr miceNonclassical MHC moleculesTarget organ diseaseCell-dependent mechanismTarget organ levelRegulation of autoimmunitySecondary lymphoid tissuesAutoreactive lymphocytesMurine lupusLpr miceSystemic diseaseAutoimmune diseasesLymphoid tissueOrgan diseaseDeficient miceT cellsSkin lesionsEnd organsOrgan levelImmune system