2021
Epidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation
Li P, Barbieri A, Walther Z, McNiff J, Panse G. Epidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation. Journal Of Cutaneous Pathology 2021, 48: 1514-1519. PMID: 34302376, DOI: 10.1111/cup.14108.Peer-Reviewed Case Reports and Technical NotesConceptsSquamous cell carcinomaOropharyngeal squamous cell carcinomaCell carcinomaDe novo squamous cell carcinomaPrimary oropharyngeal squamous cell carcinomaTonsillar squamous cell carcinomaTargetable genetic aberrationsLesion biopsy specimensSkin biopsy specimenSkin lesion biopsy specimensMetastatic diseaseEpidermal involvementEpidermotropic metastasesMetastatic lesionsPoor prognosisBiopsy specimenCase reportClinical historyBiopsy specimensSecondary diseaseSkin lesionsTumor originMetastatic specimensMetastasisNeck skin
2001
Pathogenesis of autoimmunity in αβ T cell-deficient lupus-prone mice
Peng S, Cappadona J, Mcniff J, Madaio M, Owen M, Hayday A, Craft J. Pathogenesis of autoimmunity in αβ T cell-deficient lupus-prone mice. Clinical & Experimental Immunology 2001, 111: 107-116. PMID: 9472669, PMCID: PMC1904839, DOI: 10.1046/j.1365-2249.1998.00424.x.Peer-Reviewed Original ResearchConceptsT cell-dependent mechanismCell-dependent mechanismEnd-organ diseaseImmune complex depositionGammadelta T cellsRenal diseaseMurine lupusComplex depositionT cellsMRL miceSkin lesionsComplement fixationT-cell-deficient animalsEnd-organ damageLupus-prone miceNon-autoimmune micePathogenesis of autoimmunityYears of ageHumoral autoimmunityLupus lesionsAutoantibody productionSkin diseasesSkin injuryTCR alphaFas antigenDeficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level
Chan O, Paliwal V, McNiff J, Park S, Bendelac A, Shlomchik M. Deficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level. The Journal Of Immunology 2001, 167: 2985-2990. PMID: 11509649, DOI: 10.4049/jimmunol.167.5.2985.Peer-Reviewed Original ResearchConceptsSkin diseasesT cell-dependent mechanismMRL/lpr miceLupus skin diseaseLupus skin lesionsMRL-Faslpr miceNonclassical MHC moleculesTarget organ diseaseCell-dependent mechanismTarget organ levelRegulation of autoimmunitySecondary lymphoid tissuesAutoreactive lymphocytesMurine lupusLpr miceSystemic diseaseAutoimmune diseasesLymphoid tissueOrgan diseaseDeficient miceT cellsSkin lesionsEnd organsOrgan levelImmune system
2000
Primary cutaneous follicle center cell lymphoma with follicular growth pattern
Cerroni L, Arzberger E, Puütz B, Hoüfler G, Metze D, Sander C, Rose C, Wolf P, Ruütten A, McNiff J, Kerl H. Primary cutaneous follicle center cell lymphoma with follicular growth pattern. Blood 2000, 95: 3922-3928. PMID: 10845929, DOI: 10.1182/blood.v95.12.3922.Peer-Reviewed Original ResearchConceptsB-cell infiltratesFollicular growth patternGerminal centersPrimary cutaneous follicle center cell lymphomaCutaneous follicle center cell lymphomaPrimary cutaneous follicular lymphomaCutaneous B-cell lymphomaCutaneous follicular lymphomaSame monoclonal populationFollicle center cell lymphomaCutaneous B-cell infiltratesBone marrow biopsyReactive germinal centersB-cell lymphomaFollicle center cellsBcl-2 protein expressionExtracutaneous spreadStaging investigationsPolymerase chain reaction analysisMarrow biopsyImmunophenotypic criteriaNeoplastic folliclesFollicular patternMonoclonal rearrangementSkin lesionsPrimary cutaneous follicle center cell lymphoma with follicular growth pattern
Cerroni L, Arzberger E, Pütz B, Höfler G, Metze D, Sander C, Rose C, Wolf P, Rütten A, McNiff J, Kerl H. Primary cutaneous follicle center cell lymphoma with follicular growth pattern. Blood 2000, 95: 3922-3928. DOI: 10.1182/blood.v95.12.3922.012k08_3922_3928.Peer-Reviewed Original ResearchB-cell infiltratesFollicular growth patternGerminal centersPrimary cutaneous follicle center cell lymphomaCutaneous follicle center cell lymphomaPrimary cutaneous follicular lymphomaCutaneous B-cell lymphomaCutaneous follicular lymphomaSame monoclonal populationFollicle center cell lymphomaCutaneous B-cell infiltratesBone marrow biopsyReactive germinal centersB-cell lymphomaFollicle center cellsBcl-2 protein expressionExtracutaneous spreadStaging investigationsPolymerase chain reaction analysisMarrow biopsyImmunophenotypic criteriaNeoplastic folliclesFollicular patternMonoclonal rearrangementSkin lesions