2022
Not all well-differentiated cutaneous squamous cell carcinomas are equal: Tumors with disparate biologic behavior have differences in protein expression via digital spatial profiling
Vesely M, Martinez-Morilla S, Gehlhausen JR, McNiff JM, Whang PG, Rimm D, Ko CJ. Not all well-differentiated cutaneous squamous cell carcinomas are equal: Tumors with disparate biologic behavior have differences in protein expression via digital spatial profiling. Journal Of The American Academy Of Dermatology 2022, 87: 695-698. PMID: 35398219, DOI: 10.1016/j.jaad.2022.03.057.Peer-Reviewed Original Research
2021
Squamous cell carcinoma arising in long-standing necrobiosis lipoidica treated with radical resection and split-thickness skin graft
Xie CB, Ring N, Damsky W, McNiff JM, Olino K, Odell I. Squamous cell carcinoma arising in long-standing necrobiosis lipoidica treated with radical resection and split-thickness skin graft. JAAD Case Reports 2021, 19: 90-93. PMID: 35024397, PMCID: PMC8724883, DOI: 10.1016/j.jdcr.2021.11.005.Peer-Reviewed Case Reports and Technical NotesEpidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation
Li P, Barbieri A, Walther Z, McNiff J, Panse G. Epidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation. Journal Of Cutaneous Pathology 2021, 48: 1514-1519. PMID: 34302376, DOI: 10.1111/cup.14108.Peer-Reviewed Case Reports and Technical NotesConceptsSquamous cell carcinomaOropharyngeal squamous cell carcinomaCell carcinomaDe novo squamous cell carcinomaPrimary oropharyngeal squamous cell carcinomaTonsillar squamous cell carcinomaTargetable genetic aberrationsLesion biopsy specimensSkin biopsy specimenSkin lesion biopsy specimensMetastatic diseaseEpidermal involvementEpidermotropic metastasesMetastatic lesionsPoor prognosisBiopsy specimenCase reportClinical historyBiopsy specimensSecondary diseaseSkin lesionsTumor originMetastatic specimensMetastasisNeck skinDesmoplastic Trichoepithelioma With Pseudocarcinomatous Hyperplasia: A Folliculosebaceous Neoplasm in Young Persons
Wang MZ, McNiff JM, McCalmont TH, LeBoit PE. Desmoplastic Trichoepithelioma With Pseudocarcinomatous Hyperplasia: A Folliculosebaceous Neoplasm in Young Persons. American Journal Of Dermatopathology 2021, 43: 788-793. PMID: 33899770, DOI: 10.1097/dad.0000000000001922.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaCell carcinomaImmunohistochemical profileMorphoeic basal cell carcinomaSquamous cell carcinomaMicrocystic adnexal carcinomaBasal cell carcinomaFollicular germinative cellsMedian ageBer-EP4Clinical manifestationsAdnexal carcinomaMalignant neoplasmsFibrotic stromaBasaloid cellsEpidermal hyperplasiaPseudocarcinomatous hyperplasiaMerkel cellsSurface epitheliumAccurate diagnosisCarcinomaTrichoepitheliomaGerminative cellsBasal layerHyperplasiaA Histopathologic Scoring System for Perineural Invasion Correlates With Adverse Outcomes in Patients With Cutaneous Squamous Cell Carcinoma.
Totonchy MB, McNiff JM, Suozzi KC, Leffell DJ, Christensen SR. A Histopathologic Scoring System for Perineural Invasion Correlates With Adverse Outcomes in Patients With Cutaneous Squamous Cell Carcinoma. Dermatologic Surgery 2021, 47: 445-451. PMID: 33795563, DOI: 10.1097/dss.0000000000002923.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaPerineural invasionSquamous cell carcinomaAdverse outcomesNerve diameterHistopathologic featuresPNI scoreCell carcinomaExtratumoral perineural invasionRetrospective cohort studyCurrent staging systemHistopathologic scoring systemTumor-related deathNumber of nervesLogistic regression analysisMedian followNerve involvementCohort studyLocal recurrenceSurgical excisionStaging systemRisk factorsMedian numberHistopathologic slidesNerve structures
2020
Cutaneous Involvement in Plasma Cell Myeloma
Panse G, Subtil A, McNiff JM, Glusac EJ, Ko CJ, Galan A, Myung P, Xu ML. Cutaneous Involvement in Plasma Cell Myeloma. American Journal Of Clinical Pathology 2020, 155: 106-116. PMID: 32885235, DOI: 10.1093/ajcp/aqaa122.Peer-Reviewed Original ResearchConceptsPlasma cell myelomaCutaneous involvementSquamous cell carcinomaAmyloid depositionCell carcinomaCell myelomaCases of PCMBone marrow involvementCyclin D1 immunoreactivityDisease-related deathLight chain restrictionCCND1 gene rearrangementMarrow involvementSkin involvementClinicopathologic featuresCytomorphologic spectrumCutaneous lesionsPoor outcomeCommon immunophenotypeChain restrictionClinical dataCytogenetic findingsOlder individualsGene rearrangementsMyeloma
2014
p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma
Alomari AK, Glusac EJ, McNiff JM. p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma. Journal Of Cutaneous Pathology 2014, 41: 839-845. PMID: 25263848, DOI: 10.1111/cup.12388.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaAtypical fibroxanthomaCell carcinomaNon-cutaneous squamous-cell carcinomaNuclear stainingNon-squamous tumorsGiant cell tumorCutaneous leiomyosarcomaExclusive nuclear stainingCell tumorsDiagnostic challengeCytokeratin MNF116Focal stainingMNF116Tumor cytoplasmLeiomyosarcomaDiagnostic accuracyControl casesSoft tissueSpecific markersP40StainingCarcinomaP63Tumors
1999
Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line.
Grossman D, McNiff J, Li F, Altieri D. Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line. Laboratory Investigation 1999, 79: 1121-6. PMID: 10496530.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaBasal cell carcinomaNonmelanoma skin cancerHypertrophic actinic keratosisCell carcinomaSkin cancerKeratinocyte cell lineCutaneous squamous cell carcinomaG0/G1 fractionCell linesAdvanced diseaseBowen's diseaseActinic keratosisSurvivin dominant-negative mutantPremalignant lesionsTherapeutic targetingApoptosis inhibitor survivinSurvivin expressionFlow cytometryWestern blottingDecreased levelsMorpheaform subtypesCancerSpontaneous apoptosisDiseaseExpression and localization of thymidine phosphorylase/platelet‐derived endothelial cell growth factor in skin and cutaneous tumors
Asgari M, Haggerty J, McNiff J, Milstone L, Schwartz P. Expression and localization of thymidine phosphorylase/platelet‐derived endothelial cell growth factor in skin and cutaneous tumors. Journal Of Cutaneous Pathology 1999, 26: 287-294. PMID: 10472757, DOI: 10.1111/j.1600-0560.1999.tb01846.x.Peer-Reviewed Original ResearchConceptsPlatelet-derived endothelial cell growth factorThymidine phosphorylase/platelet-derived endothelial cell growth factorPD-ECGF expressionEndothelial cell growth factorCutaneous tumorsPD-ECGFCell carcinomaCell growth factorGrowth factorSquamous cell carcinomaMerkel cell carcinomaBasal cell carcinomaVariety of tumorsCell of originNuclei of keratinocytesFollicular infundibulumTumor degreeDifferentiation of keratinocytesEccrine poromaImmunohistochemical analysisPositive stainingIntradermal nevusNormal skinTumorsIntense staining
1998
Psoralen photochemotherapy, clinical efficacy, and photomutagenicity: The role of molecular epidemiology in minimizing risks
Gasparro FP, Liao B, Foley PJ, Wang XM, McNiff J. Psoralen photochemotherapy, clinical efficacy, and photomutagenicity: The role of molecular epidemiology in minimizing risks. Environmental And Molecular Mutagenesis 1998, 31: 105-112. PMID: 9544188, DOI: 10.1002/(sici)1098-2280(1998)31:2<105::aid-em2>3.0.co;2-l.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaHuman squamous cell carcinomaP53 mutation spectrumMurine squamous cell carcinomaEfficacy of PUVATreatment of psoriasisP53 tumor suppressor geneMutation spectrumPsoriasis patientsUVB phototherapyClinical efficacyPsoralen photochemotherapyCell carcinomaTherapeutic historyPUVATumor progressionUVB exposureMolecular epidemiologyPatientsTumor suppressor geneHuman cancersCommon mutationsPsoriasisSkin cellsPhotochemotherapy
1997
An Unexpected Spectrum of p53 Mutations from Squamous Cell Carcinomas in Psoriasis Patients Treated with PUVA
Wang X, McNiff J, Klump V, Asgari M, Gasparro F. An Unexpected Spectrum of p53 Mutations from Squamous Cell Carcinomas in Psoriasis Patients Treated with PUVA. Photochemistry And Photobiology 1997, 66: 294-299. PMID: 9277151, DOI: 10.1111/j.1751-1097.1997.tb08658.x.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaCell carcinomaP53 mutationsTreatment of psoriasisType mutationsP53 tumor suppressor genePUVA patientsPsoriasis patientsUVB phototherapyImmune suppressionTherapeutic historyNormal controlsPatientsTumor progressionUVB exposureTumor suppressor geneCarcinomaSingle-strand conformational polymorphismLong-wavelength ultraviolet radiationHuman cancersPUVAPsoriasisSkin cellsPhotochemotherapyDipyrimidine sites