2023
Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells
Sacirbegovic F, Günther M, Greco A, Zhao D, Wang X, Zhou M, Rosenberger S, Oberbarnscheidt M, Held W, McNiff J, Jain D, Höfer T, Shlomchik W. Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells. Immunity 2023, 56: 369-385.e6. PMID: 36720219, PMCID: PMC10182785, DOI: 10.1016/j.immuni.2023.01.003.Peer-Reviewed Original ResearchConceptsHost diseaseAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationChronic antigen stimulationStem cell transplantationAlloreactive effectorsAdoptive transferCell transplantationΑβ TAntigen stimulationCell exhaustionGVHDRecipient tissuesEffector poolMajor causeCell clonesTarget tissuesAffected tissuesDiseaseGraftTissueTCF-1CellsDiseased tissuesMorbidity
2013
PD-L1 and PD-L2 Protect The Heart In a T-Cell Receptor Transgenic Model Of Graft-Versus Host Disease
Juchem K, Anderson B, Zhang C, Sharpe A, McNiff J, Demetris A, Shlomchik M, Shlomchik W. PD-L1 and PD-L2 Protect The Heart In a T-Cell Receptor Transgenic Model Of Graft-Versus Host Disease. Blood 2013, 122: 4479. DOI: 10.1182/blood.v122.21.4479.4479.Peer-Reviewed Original ResearchDonor bone marrowPD-L1PD-L1/2T cellsBone marrowLate weight lossWeight lossHost diseasePD-1Graft Versus Host DiseaseInhibitory molecules PD-1Effector memory T cellsT cell receptor transgenic modelAllogeneic stem cell transplantationT-cell-mediated pathogenesisMore chronic phasesPD-L1/2 expressionRadioresistant stromal cellsDays post transplantHost T cellsCD4 T cellsMemory T cellsStem cell transplantationNaive T cellsEarly weight loss
2011
A repertoire independent and cell intrinsic defect in murine GVHD induction by effector memory T cells (169.6)
Juchem K, Anderson B, Zhang C, McNiff J, Demetris A, Caton A, Shlomchik W, Shlomchik M. A repertoire independent and cell intrinsic defect in murine GVHD induction by effector memory T cells (169.6). The Journal Of Immunology 2011, 186: 169.6-169.6. DOI: 10.4049/jimmunol.186.supp.169.6.Peer-Reviewed Original ResearchMemory T cellsEffector memory T cellsT cellsGVHD inductionAllogeneic stem cell transplantationMemory T cell poolCentral memory T cellsT cell receptor transgenicT cell receptor repertoireT cell poolStem cell transplantationCell receptor repertoireNaïve T cellsTg T cellsSyngeneic bone marrowCell-intrinsic defectTransient GVHDHost diseasePost transplantMajor complicationsPD-1PD-L1Transgenic recipientsCell transplantationNaive CD4
2009
Donor APCs Promote Gvhd in MHC-Mismatched Transplants by Indirectly Presenting Host Minor Histocompatibility Antigens.
Wang X, Martone C, Demetris A, McNiff J, Shlomchik W. Donor APCs Promote Gvhd in MHC-Mismatched Transplants by Indirectly Presenting Host Minor Histocompatibility Antigens. Blood 2009, 114: 689. DOI: 10.1182/blood.v114.22.689.689.Peer-Reviewed Original ResearchAntigen presenting cellsBALB/c miceHost minor histocompatibility antigensCD4 cellsMinor histocompatibility antigensT cellsC miceAcute GVHDAllogeneic MHCChronic GVHDDonor BMHistocompatibility antigensIndirect presentationFemale recipientsT cell receptor transgenic T cellsDay 7Bone marrow/stem cell transplantationFemale BALB/c miceHost antigen presenting cellsMale BALB/c miceRecipient antigen presenting cellsBALB/c modelAlloreactive CD4 cellsPrime T cellsStem cell transplantation
2004
Distinct Roles for Donor and Host Antigen Presenting Cells and Costimulatory Molecules in Murine Chronic Graft-Vs-Host Disease: Requirements Depend on Target Organ.
Anderson B, McNiff J, Jain D, Blazar B, Shlomchik W, Shlomchik M. Distinct Roles for Donor and Host Antigen Presenting Cells and Costimulatory Molecules in Murine Chronic Graft-Vs-Host Disease: Requirements Depend on Target Organ. Blood 2004, 104: 3059. DOI: 10.1182/blood.v104.11.3059.3059.Peer-Reviewed Original ResearchChronic GVHDCutaneous chronic GVHDHost APCsCD4 cellsWT BMDonor APCsAcute GVHDHost diseaseRecipient APCsAPC requirementsHost antigen presenting cellsAllogeneic stem cell transplantationChronic Graft-vsDonor CD4 cellsPre-transplant weightDonor T cellsStem cell transplantationCostimulatory molecules CD80Antigen presenting cellsSite of diseaseChimeric recipientsCutaneous GVHDDonor BMGraft-vsGVHD prevention
2001
Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease
Liu J, Anderson B, Robert M, McNiff J, Emerson S, Shlomchik W, Shlomchik M. Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease. Blood 2001, 98: 3367-3375. PMID: 11719376, DOI: 10.1182/blood.v98.12.3367.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DeathCytokinesDisease Models, AnimalFlow CytometryGanciclovirGraft vs Host DiseaseGraft vs Leukemia EffectHematopoiesisHematopoietic Stem CellsInterleukin-2Interleukin-4Lymphocyte SubsetsMaleMiceMice, TransgenicPromoter Regions, GeneticSimplexvirusSpleenThymidine KinaseThymus GlandT-LymphocytesWeight GainConceptsDonor T cellsT cellsT2 cellsGVHD reactionsHost diseaseInterleukin-2Herpes simplex virus thymidine kinase gene transductionAllogeneic stem cell transplantationCytokine-producing T cellsPrevention of GVHDStem cell transplantationReversal of diseaseT cell deletionLater time pointsAcute graftCytokine polarizationOngoing GVHDClinical GVHDAntibody infusionPeak diseaseClinical effectsCell transplantationIL-4 promoterGVHDDeficient mice