2004
IL-11 PROTECTS HUMAN MICROVASCULAR ENDOTHELIUM FROM ALLOINJURY IN VIVO BY INDUCTION OF SURVIVIN EXPRESSION
Kirkiles-Smith N, Mahboubi K, Plescia J, McNiff J, Karras J, Schechner J, Altieri D, Pober J. IL-11 PROTECTS HUMAN MICROVASCULAR ENDOTHELIUM FROM ALLOINJURY IN VIVO BY INDUCTION OF SURVIVIN EXPRESSION. Cardiovascular Pathology 2004, 13: 112. DOI: 10.1016/j.carpath.2004.03.336.Peer-Reviewed Original Research
1999
Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma
Grossman D, McNiff J, Li F, Altieri D. Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma. Journal Of Investigative Dermatology 1999, 113: 1076-1081. PMID: 10594755, DOI: 10.1046/j.1523-1747.1999.00776.x.Peer-Reviewed Original ResearchConceptsInvasive malignant melanomaMalignant melanomaDominant negative mutantCultured normal human melanocytesCell cycle progressionApoptosis inhibitor Bcl-2G1 DNA contentNormal human melanocytesSurvivin expressionApoptosis inhibitor survivinApoptosis regulationEndogenous survivinNegative mutantTwo-color flow cytometryGenotoxic stimuliMalignant melanoma cell linesSurvivin dominant-negative mutantCycle progressionMetastatic malignant melanomaApoptosis inhibitorMelanoma cell linesHuman melanocytesMIB-1 stainingApoptosis inhibitionCases of nevusExpression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line.
Grossman D, McNiff J, Li F, Altieri D. Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line. Laboratory Investigation 1999, 79: 1121-6. PMID: 10496530.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaBasal cell carcinomaNonmelanoma skin cancerHypertrophic actinic keratosisCell carcinomaSkin cancerKeratinocyte cell lineCutaneous squamous cell carcinomaG0/G1 fractionCell linesAdvanced diseaseBowen's diseaseActinic keratosisSurvivin dominant-negative mutantPremalignant lesionsTherapeutic targetingApoptosis inhibitor survivinSurvivin expressionFlow cytometryWestern blottingDecreased levelsMorpheaform subtypesCancerSpontaneous apoptosisDisease