2023
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Islam F, McNiff J, Craft J. HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. JCI Insight 2023, 8: e166076. PMID: 37526979, PMCID: PMC10543720, DOI: 10.1172/jci.insight.166076.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusLupus skin diseaseT cellsSkin diseasesCytotoxic signatureInflammatory infiltrateHIF-1Tissue damageKidney-infiltrating T cellsSkin-infiltrating T cellsAutoimmune skin diseaseHIF-1 inhibitionSkin tissue damageLupus erythematosusSystemic diseaseTissue inflammationGranzyme BMouse modelInflammatory gene programDiseaseProtein levelsInfiltratesSkin environmentGene programPresent study
2021
Leukocytoclastic Vasculitis and Microvascular Occlusion Key Concepts for the Working Pathologist
Ko CJ, Gehlhausen JR, McNiff JM. Leukocytoclastic Vasculitis and Microvascular Occlusion Key Concepts for the Working Pathologist. Surgical Pathology Clinics 2021, 14: 309-325. PMID: 34023108, DOI: 10.1016/j.path.2021.01.006.Peer-Reviewed Original ResearchConceptsLeukocytoclastic vasculitisMicrovascular occlusionSmall vessel leukocytoclastic vasculitisMedium-sized vesselsSame differential diagnosisBiopsy findingsDermal involvementSystemic diseaseCertain infectionsDifferential diagnosisVasculitisDepth of involvementClinical diagnosisOcclusionDiagnosisVessel sizeInvolvementVesselsSize of vesselsCalciphylaxis
2001
Deficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level
Chan O, Paliwal V, McNiff J, Park S, Bendelac A, Shlomchik M. Deficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level. The Journal Of Immunology 2001, 167: 2985-2990. PMID: 11509649, DOI: 10.4049/jimmunol.167.5.2985.Peer-Reviewed Original ResearchConceptsSkin diseasesT cell-dependent mechanismMRL/lpr miceLupus skin diseaseLupus skin lesionsMRL-Faslpr miceNonclassical MHC moleculesTarget organ diseaseCell-dependent mechanismTarget organ levelRegulation of autoimmunitySecondary lymphoid tissuesAutoreactive lymphocytesMurine lupusLpr miceSystemic diseaseAutoimmune diseasesLymphoid tissueOrgan diseaseDeficient miceT cellsSkin lesionsEnd organsOrgan levelImmune system
1998
Mycosis Fungoides Palmaris et Plantaris or Acral Pagetoid Reticulosis?
McNiff J, Schechner J, Crotty P, Glusac E. Mycosis Fungoides Palmaris et Plantaris or Acral Pagetoid Reticulosis? American Journal Of Dermatopathology 1998, 20: 271-275. PMID: 9650701, DOI: 10.1097/00000372-199806000-00009.Peer-Reviewed Original ResearchConceptsMycosis fungoides palmaris et plantarisWoringer-Kolopp diseasePalmaris et plantarisPagetoid reticulosisEpidermotropic atypical lymphocytesPolymerase chain reaction studiesT-cell receptor betaT-cell clonalityClonal gene rearrangementsEpidermotropic lymphocytesRecurrent plaquesAtypical lymphocytesCutaneous plaquesSuppressor/Dermal infiltrateMycosis fungoidesSystemic diseaseAcral sitesT cellsBiologic potentialHistologic resemblanceIntraepidermal lymphocytesReceptor betaDiseasePlantaris