2011
A repertoire independent and cell intrinsic defect in murine GVHD induction by effector memory T cells (169.6)
Juchem K, Anderson B, Zhang C, McNiff J, Demetris A, Caton A, Shlomchik W, Shlomchik M. A repertoire independent and cell intrinsic defect in murine GVHD induction by effector memory T cells (169.6). The Journal Of Immunology 2011, 186: 169.6-169.6. DOI: 10.4049/jimmunol.186.supp.169.6.Peer-Reviewed Original ResearchMemory T cellsEffector memory T cellsT cellsGVHD inductionAllogeneic stem cell transplantationMemory T cell poolCentral memory T cellsT cell receptor transgenicT cell receptor repertoireT cell poolStem cell transplantationCell receptor repertoireNaïve T cellsTg T cellsSyngeneic bone marrowCell-intrinsic defectTransient GVHDHost diseasePost transplantMajor complicationsPD-1PD-L1Transgenic recipientsCell transplantationNaive CD4
2009
A New TCR Transgenic Model of GVHD Reveals That, Independent of Repertoire, Effector Memory T Cells Are Severely Limited, and Central Memory T Cells Somewhat Limited, in Their Ability to Cause GVHD.
Wilkinson K, Anderson B, McNiff J, Demetris A, Shlomchik W, Shlomchik M. A New TCR Transgenic Model of GVHD Reveals That, Independent of Repertoire, Effector Memory T Cells Are Severely Limited, and Central Memory T Cells Somewhat Limited, in Their Ability to Cause GVHD. Blood 2009, 114: 233. DOI: 10.1182/blood.v114.22.233.233.Peer-Reviewed Original ResearchEM T cellsCD4 T cellsCM CD4 T cellsCM T cellsDays post transplantMemory T cellsTCR transgenic modelT cellsPost transplantTs1 cellsLymph nodesCell recipientsWeight lossTransgenic modelCentral memory CD4 T cellsEffector memory T cellsAllogeneic stem cell transplantationMemory CD4 T cellsT cell receptor repertoireCentral memory TContext of GVHDInduction of GVHDInitiation of GVHDModel of GVHDRAG-deficient background