2023
Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells
Sacirbegovic F, Günther M, Greco A, Zhao D, Wang X, Zhou M, Rosenberger S, Oberbarnscheidt M, Held W, McNiff J, Jain D, Höfer T, Shlomchik W. Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells. Immunity 2023, 56: 369-385.e6. PMID: 36720219, PMCID: PMC10182785, DOI: 10.1016/j.immuni.2023.01.003.Peer-Reviewed Original ResearchConceptsHost diseaseAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationChronic antigen stimulationStem cell transplantationAlloreactive effectorsAdoptive transferCell transplantationΑβ TAntigen stimulationCell exhaustionGVHDRecipient tissuesEffector poolMajor causeCell clonesTarget tissuesAffected tissuesDiseaseGraftTissueTCF-1CellsDiseased tissuesMorbidity
2005
CD8+ but Not CD4+ T Cells Require Cognate Interactions with Target Tissues To Mediate GVHD across Only Minor H Antigens but CD4+ and CD8+ T Cells Both Require Direct Leukemic Contact for GVL.
Shlomchik W, Matte C, Liu J, Jain D, McNiff J. CD8+ but Not CD4+ T Cells Require Cognate Interactions with Target Tissues To Mediate GVHD across Only Minor H Antigens but CD4+ and CD8+ T Cells Both Require Direct Leukemic Contact for GVL. Blood 2005, 106: 580. DOI: 10.1182/blood.v106.11.580.580.Peer-Reviewed Original ResearchCD8-mediated GVHDDirect cognate interactionT cellsSecond transplantCD4 cellsCD8 cellsHost antigensCognate interactionMHCII expressionBone marrowDonor CD4 cellsDonor-derived APCsT-cell releaseTarget tissuesAlloreactive T cellsBone marrow chimerasMinor H antigensCognate T cellsChimeric recipientsDonor BMGVHD lethalityHistologic GVHDHost APCsLess GVHDLeukemic expression