2013
PD-L1 and PD-L2 Protect The Heart In a T-Cell Receptor Transgenic Model Of Graft-Versus Host Disease
Juchem K, Anderson B, Zhang C, Sharpe A, McNiff J, Demetris A, Shlomchik M, Shlomchik W. PD-L1 and PD-L2 Protect The Heart In a T-Cell Receptor Transgenic Model Of Graft-Versus Host Disease. Blood 2013, 122: 4479. DOI: 10.1182/blood.v122.21.4479.4479.Peer-Reviewed Original ResearchDonor bone marrowPD-L1PD-L1/2T cellsBone marrowLate weight lossWeight lossHost diseasePD-1Graft Versus Host DiseaseInhibitory molecules PD-1Effector memory T cellsT cell receptor transgenic modelAllogeneic stem cell transplantationT-cell-mediated pathogenesisMore chronic phasesPD-L1/2 expressionRadioresistant stromal cellsDays post transplantHost T cellsCD4 T cellsMemory T cellsStem cell transplantationNaive T cellsEarly weight loss
2009
A New TCR Transgenic Model of GVHD Reveals That, Independent of Repertoire, Effector Memory T Cells Are Severely Limited, and Central Memory T Cells Somewhat Limited, in Their Ability to Cause GVHD.
Wilkinson K, Anderson B, McNiff J, Demetris A, Shlomchik W, Shlomchik M. A New TCR Transgenic Model of GVHD Reveals That, Independent of Repertoire, Effector Memory T Cells Are Severely Limited, and Central Memory T Cells Somewhat Limited, in Their Ability to Cause GVHD. Blood 2009, 114: 233. DOI: 10.1182/blood.v114.22.233.233.Peer-Reviewed Original ResearchEM T cellsCD4 T cellsCM CD4 T cellsCM T cellsDays post transplantMemory T cellsTCR transgenic modelT cellsPost transplantTs1 cellsLymph nodesCell recipientsWeight lossTransgenic modelCentral memory CD4 T cellsEffector memory T cellsAllogeneic stem cell transplantationMemory CD4 T cellsT cell receptor repertoireCentral memory TContext of GVHDInduction of GVHDInitiation of GVHDModel of GVHDRAG-deficient background
2008
Recipient Langerhans Cells Are Neither Required Nor Sufficient for GVHD Induction in MHC-Matched Allogeneic BMT, but a Langerin+ Cell Is a Pivotal Regulator of Langerhans Cell Turnover Post Transplantation
Li H, Kaplan D, Demetris A, McNiff J, Shlomchik M, Shlomchik W. Recipient Langerhans Cells Are Neither Required Nor Sufficient for GVHD Induction in MHC-Matched Allogeneic BMT, but a Langerin+ Cell Is a Pivotal Regulator of Langerhans Cell Turnover Post Transplantation. Blood 2008, 112: 3511. DOI: 10.1182/blood.v112.11.3511.3511.Peer-Reviewed Original ResearchRecipient antigen-presenting cellsHost Langerhans cellsAntigen-presenting cellsBone marrow transplantAllogeneic bone marrow transplantRecipient Langerhans cellsDonor T cellsGVHD inductionEpidermal Langerhans cellsLangerhans cellsBone marrowSkin GVHDMarrow transplantT cellsAllogeneic donor T cellsAlloreactive donor T cellsDonor-derived Langerhans cellsMajor antigen-presenting cellsHost antigen-presenting cellsProfessional antigen-presenting cellsWeight lossDonor Langerhans cellsExpression of langerinTime of transplantUV-induced inflammation