2023
HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease
Little A, Chen P, Vesely M, Khan R, Fiedler J, Garritano J, Islam F, McNiff J, Craft J. HIF-1 regulates pathogenic cytotoxic T cells in lupus skin disease. JCI Insight 2023, 8: e166076. PMID: 37526979, PMCID: PMC10543720, DOI: 10.1172/jci.insight.166076.Peer-Reviewed Original ResearchConceptsCutaneous lupus erythematosusLupus skin diseaseT cellsSkin diseasesCytotoxic signatureInflammatory infiltrateHIF-1Tissue damageKidney-infiltrating T cellsSkin-infiltrating T cellsAutoimmune skin diseaseHIF-1 inhibitionSkin tissue damageLupus erythematosusSystemic diseaseTissue inflammationGranzyme BMouse modelInflammatory gene programDiseaseProtein levelsInfiltratesSkin environmentGene programPresent study
2020
Cutaneous Involvement in Plasma Cell Myeloma
Panse G, Subtil A, McNiff JM, Glusac EJ, Ko CJ, Galan A, Myung P, Xu ML. Cutaneous Involvement in Plasma Cell Myeloma. American Journal Of Clinical Pathology 2020, 155: 106-116. PMID: 32885235, DOI: 10.1093/ajcp/aqaa122.Peer-Reviewed Original ResearchConceptsPlasma cell myelomaCutaneous involvementSquamous cell carcinomaAmyloid depositionCell carcinomaCell myelomaCases of PCMBone marrow involvementCyclin D1 immunoreactivityDisease-related deathLight chain restrictionCCND1 gene rearrangementMarrow involvementSkin involvementClinicopathologic featuresCytomorphologic spectrumCutaneous lesionsPoor outcomeCommon immunophenotypeChain restrictionClinical dataCytogenetic findingsOlder individualsGene rearrangementsMyeloma
2001
Pathogenesis of autoimmunity in αβ T cell-deficient lupus-prone mice
Peng S, Cappadona J, Mcniff J, Madaio M, Owen M, Hayday A, Craft J. Pathogenesis of autoimmunity in αβ T cell-deficient lupus-prone mice. Clinical & Experimental Immunology 2001, 111: 107-116. PMID: 9472669, PMCID: PMC1904839, DOI: 10.1046/j.1365-2249.1998.00424.x.Peer-Reviewed Original ResearchConceptsT cell-dependent mechanismCell-dependent mechanismEnd-organ diseaseImmune complex depositionGammadelta T cellsRenal diseaseMurine lupusComplex depositionT cellsMRL miceSkin lesionsComplement fixationT-cell-deficient animalsEnd-organ damageLupus-prone miceNon-autoimmune micePathogenesis of autoimmunityYears of ageHumoral autoimmunityLupus lesionsAutoantibody productionSkin diseasesSkin injuryTCR alphaFas antigen
2000
Humanized In Vivo Model for Streptococcal Impetigo
Scaramuzzino D, McNiff J, Bessen D. Humanized In Vivo Model for Streptococcal Impetigo. Infection And Immunity 2000, 68: 2880-2887. PMID: 10768985, PMCID: PMC97500, DOI: 10.1128/iai.68.5.2880-2887.2000.Peer-Reviewed Original ResearchConceptsStreptococcal impetigoVivo modelPattern AGross pathology scoresD strainsHuman neonatal foreskinEmm pattern ASevere infectionsEpidemiological findingsPathology scoresPurulent exudateSCID micePolymorphonuclear leukocytesPositive cocciNeonatal foreskinImpetigoC strainDays postinoculationMouse originVirulent strainGranular keratinocytesIntact epidermisStratum corneumCocciEpidermis
1999
Expression and localization of thymidine phosphorylase/platelet‐derived endothelial cell growth factor in skin and cutaneous tumors
Asgari M, Haggerty J, McNiff J, Milstone L, Schwartz P. Expression and localization of thymidine phosphorylase/platelet‐derived endothelial cell growth factor in skin and cutaneous tumors. Journal Of Cutaneous Pathology 1999, 26: 287-294. PMID: 10472757, DOI: 10.1111/j.1600-0560.1999.tb01846.x.Peer-Reviewed Original ResearchConceptsPlatelet-derived endothelial cell growth factorThymidine phosphorylase/platelet-derived endothelial cell growth factorPD-ECGF expressionEndothelial cell growth factorCutaneous tumorsPD-ECGFCell carcinomaCell growth factorGrowth factorSquamous cell carcinomaMerkel cell carcinomaBasal cell carcinomaVariety of tumorsCell of originNuclei of keratinocytesFollicular infundibulumTumor degreeDifferentiation of keratinocytesEccrine poromaImmunohistochemical analysisPositive stainingIntradermal nevusNormal skinTumorsIntense staining
1998
Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin
Murray A, Schechner J, Epperson D, Sultan P, McNiff J, Hughes C, Lorber M, Askenase P, Pober J. Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin. American Journal Of Pathology 1998, 153: 627-638. PMID: 9708821, PMCID: PMC1852982, DOI: 10.1016/s0002-9440(10)65604-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCD8-Positive T-LymphocytesCyclosporineDrug Therapy, CombinationEndothelium, VascularEnzyme-Linked Immunosorbent AssayFlow CytometryGenes, MHC Class IIGraft RejectionHumansImmunosuppressive AgentsKeratinocytesMiceMice, SCIDMicrocirculationPolyenesSirolimusSkinSkin TransplantationT-LymphocytesTransplantation, HomologousVascular Cell Adhesion Molecule-1ConceptsPeripheral blood mononuclear cellsHuman peripheral blood mononuclear cellsSkin allograft modelMicrovascular injuryT cellsCell infiltrateAllograft modelWhole peripheral blood mononuclear cellsT cell-dependent mechanismT cell-mediated rejectionHuman natural killer cellsSCID/beige miceEndothelial cell sloughingT Cell-MediatedCell-mediated rejectionCombination of cyclosporineT-cell infiltratesCell-dependent mechanismMononuclear cell infiltrateNatural killer cellsMononuclear cell infiltrationBlood mononuclear cellsSkin graft modelHuman immune responseImmunoglobulin G antibodiesMycosis Fungoides Palmaris et Plantaris or Acral Pagetoid Reticulosis?
McNiff J, Schechner J, Crotty P, Glusac E. Mycosis Fungoides Palmaris et Plantaris or Acral Pagetoid Reticulosis? American Journal Of Dermatopathology 1998, 20: 271-275. PMID: 9650701, DOI: 10.1097/00000372-199806000-00009.Peer-Reviewed Original ResearchConceptsMycosis fungoides palmaris et plantarisWoringer-Kolopp diseasePalmaris et plantarisPagetoid reticulosisEpidermotropic atypical lymphocytesPolymerase chain reaction studiesT-cell receptor betaT-cell clonalityClonal gene rearrangementsEpidermotropic lymphocytesRecurrent plaquesAtypical lymphocytesCutaneous plaquesSuppressor/Dermal infiltrateMycosis fungoidesSystemic diseaseAcral sitesT cellsBiologic potentialHistologic resemblanceIntraepidermal lymphocytesReceptor betaDiseasePlantaris