2024
Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review
Turner N, Ko C, McNiff J, Galan A. Pitfalls of PRAME Immunohistochemistry in a Large Series of Melanocytic and Nonmelanocytic Lesions With Literature Review. American Journal Of Dermatopathology 2024, 46: 21-30. PMID: 37982498, DOI: 10.1097/dad.0000000000002584.Peer-Reviewed Original ResearchConceptsConventional malignant melanomaMalignant melanomaPRAME immunohistochemistryBorderline lesionsNonmelanocytic lesionsDysplastic neviAmerican Joint CommitteePathological tumor stageMalignant melanocytic proliferationsBanal melanocytic nevusUlceration statusInstitution experienceBreslow depthMean ageTumor stageClinicopathologic correlationConsecutive casesMale genderAtypical fibroxanthomaSevere atypiaJoint CommitteeLarge seriesAmbiguous melanocytic lesionsMelanocytic proliferationMalignant counterparts
2023
IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression
Tang H, Panse G, Braddock D, Perincheri S, Xu M, McNiff J. IRF8 may be a useful marker for blastic plasmacytoid dendritic cell neoplasm, especially with weak CD123 expression. Journal Of Cutaneous Pathology 2023, 50: 595-600. PMID: 37082914, DOI: 10.1111/cup.14439.Peer-Reviewed Original ResearchConceptsBlastic plasmacytoid dendritic cell neoplasmPlasmacytoid dendritic cell neoplasmDendritic cell neoplasmPunch biopsy specimenBiopsy specimenCell neoplasmsCase of BPDCNUseful markerTumor cellsTCL-1 expressionAtypical mononuclear cellsBone marrow involvementDiffuse dermal infiltrateDendritic cell lineagePotential diagnostic pitfallRegulatory factor 8TCL-1BPDCN casesCD123 expressionMarrow involvementDermal infiltrateCutaneous nodulesMyelodysplastic syndromeSkin nodulesMononuclear cellsPRAME immunohistochemistry can distinguish melanocytic pseudonests of lichenoid reactions from melanoma in situ
Roy S, Panse G, McNiff J. PRAME immunohistochemistry can distinguish melanocytic pseudonests of lichenoid reactions from melanoma in situ. Journal Of Cutaneous Pathology 2023, 50: 450-454. PMID: 36789669, DOI: 10.1111/cup.14407.Peer-Reviewed Original Research
2022
Interface change in early mycosis fungoides: A potential mimicker of benign dermatoses
Tsang M, McNiff J. Interface change in early mycosis fungoides: A potential mimicker of benign dermatoses. Journal Of Cutaneous Pathology 2022, 50: 266-274. PMID: 36444501, DOI: 10.1111/cup.14369.Peer-Reviewed Original ResearchConceptsConnective tissue diseaseEarly mycosis fungoidesMycosis fungoidesInterface dermatitisEarly biopsy specimensPapillary dermal fibrosisPatch-stage diseaseLymphocyte atypiaEarly biopsyRepeat biopsyHistopathologic featuresInflammatory dermatosesPotential mimickersTissue diseaseDefinitive diagnosisLichenoid patternBenign dermatosesBiopsy specimensClinicopathologic correlationDermal-epidermal junctionHistopathologic evolutionAncillary studiesBenign diagnosisDermal fibrosisHistopathologic cluesNot all well-differentiated cutaneous squamous cell carcinomas are equal: Tumors with disparate biologic behavior have differences in protein expression via digital spatial profiling
Vesely M, Martinez-Morilla S, Gehlhausen JR, McNiff JM, Whang PG, Rimm D, Ko CJ. Not all well-differentiated cutaneous squamous cell carcinomas are equal: Tumors with disparate biologic behavior have differences in protein expression via digital spatial profiling. Journal Of The American Academy Of Dermatology 2022, 87: 695-698. PMID: 35398219, DOI: 10.1016/j.jaad.2022.03.057.Peer-Reviewed Original Research
2021
Clustered intraepidermal lymphocytes and Langerhans cell microgranulomas are consistently observed in hyperkeratotic palmoplantar eczema compared with palmoplantar psoriasis and mycosis fungoides palmaris et plantaris
Kim SR, McNiff JM, Ko CJ. Clustered intraepidermal lymphocytes and Langerhans cell microgranulomas are consistently observed in hyperkeratotic palmoplantar eczema compared with palmoplantar psoriasis and mycosis fungoides palmaris et plantaris. Journal Of The American Academy Of Dermatology 2021, 87: 884-886. PMID: 34883152, DOI: 10.1016/j.jaad.2021.11.057.Peer-Reviewed Original ResearchCutaneous involvement by plasma cell myeloma with aberrant CD4 expression
Li P, Panse G, Singh S, Krivda SJ, McNiff JM. Cutaneous involvement by plasma cell myeloma with aberrant CD4 expression. Journal Of Cutaneous Pathology 2021, 49: 921-924. PMID: 36222211, DOI: 10.1111/cup.14141.Peer-Reviewed Original ResearchEpidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation
Li P, Barbieri A, Walther Z, McNiff J, Panse G. Epidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation. Journal Of Cutaneous Pathology 2021, 48: 1514-1519. PMID: 34302376, DOI: 10.1111/cup.14108.Peer-Reviewed Case Reports and Technical NotesConceptsSquamous cell carcinomaOropharyngeal squamous cell carcinomaCell carcinomaDe novo squamous cell carcinomaPrimary oropharyngeal squamous cell carcinomaTonsillar squamous cell carcinomaTargetable genetic aberrationsLesion biopsy specimensSkin biopsy specimenSkin lesion biopsy specimensMetastatic diseaseEpidermal involvementEpidermotropic metastasesMetastatic lesionsPoor prognosisBiopsy specimenCase reportClinical historyBiopsy specimensSecondary diseaseSkin lesionsTumor originMetastatic specimensMetastasisNeck skinA Histopathologic Scoring System for Perineural Invasion Correlates With Adverse Outcomes in Patients With Cutaneous Squamous Cell Carcinoma.
Totonchy MB, McNiff JM, Suozzi KC, Leffell DJ, Christensen SR. A Histopathologic Scoring System for Perineural Invasion Correlates With Adverse Outcomes in Patients With Cutaneous Squamous Cell Carcinoma. Dermatologic Surgery 2021, 47: 445-451. PMID: 33795563, DOI: 10.1097/dss.0000000000002923.Peer-Reviewed Original ResearchConceptsCutaneous squamous cell carcinomaPerineural invasionSquamous cell carcinomaAdverse outcomesNerve diameterHistopathologic featuresPNI scoreCell carcinomaExtratumoral perineural invasionRetrospective cohort studyCurrent staging systemHistopathologic scoring systemTumor-related deathNumber of nervesLogistic regression analysisMedian followNerve involvementCohort studyLocal recurrenceSurgical excisionStaging systemRisk factorsMedian numberHistopathologic slidesNerve structuresLichenoid dermatoses with pseudomelanocytic nests vs inflamed melanoma in situ: A comparative study
Panse G, McNiff JM. Lichenoid dermatoses with pseudomelanocytic nests vs inflamed melanoma in situ: A comparative study. Journal Of Cutaneous Pathology 2021, 48: 745-749. PMID: 33350494, DOI: 10.1111/cup.13945.Peer-Reviewed Original ResearchConceptsPseudomelanocytic nestsLichenoid dermatosesDermoepidermal junctionHistopathological featuresPagetoid scatterCytologic atypiaDifferent histopathological featuresSun-damaged skinSignificant cytologic atypiaLichenoid inflammationSolitary melanocytesLichenoid keratosisClinicopathological correlationBiopsy specimensNon-melanocytic lesionsDiagnostic pitfallsAtypical melanocytesDermatosesSingle melanocytesAtypiaMelanomaMelanocytesConfluent growthBenign process
2020
Epidermolytic Acanthoma: Findings of a Large Retrospective Study
Roy SF, McNiff JM. Epidermolytic Acanthoma: Findings of a Large Retrospective Study. International Journal Of Gynecological Pathology 2020, 40: e4-e4. PMID: 33290356, DOI: 10.1097/pgp.0000000000000672.Peer-Reviewed Original Research
2019
Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern
Roy SF, Ko CJ, Moeckel GW, Mcniff JM. Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern. Journal Of Cutaneous Pathology 2019, 46: 742-747. PMID: 31157457, DOI: 10.1111/cup.13522.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBowen's DiseaseFemaleHumansKeratosis, SeborrheicMaleMiddle AgedRetrospective StudiesSkin NeoplasmsWartsConceptsBenign keratosesDistinctive histopathologic findingsHistological reaction patternEpidermolytic hyperkeratosisReaction patternsBowen's diseaseRetrospective reviewMean ageProminent granular layerHistopathologic findingsEpidermoid cystKeratin immunohistochemistryClinical impressionSeborrheic keratosisPositive stainingNeck areaAbnormal keratinizationKeratohyaline granulesUnique reaction patternReproducible findingsKeratosesCytoplasmic areaGranular layerHyperkeratosisPrevious reportsObservational Study Examining the Diagnostic Practice of Ki67 Staining for Melanocytic Lesions
Vyas NS, Charifa A, Desman GT, Goldberg M, Singh R, Phelps RG, McNiff JM. Observational Study Examining the Diagnostic Practice of Ki67 Staining for Melanocytic Lesions. American Journal Of Dermatopathology 2019, Publish Ahead of Print: &na;. PMID: 31233404, DOI: 10.1097/dad.0000000000001379.Peer-Reviewed Original ResearchMultinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria
Roy SF, Dong D, Myung P, McNiff JM. Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria. Journal Of Cutaneous Pathology 2019, 46: 563-569. PMID: 30927287, DOI: 10.1111/cup.13463.Peer-Reviewed Original ResearchConceptsMultinucleate cell angiohistiocytomaFollicular inductionDiagnostic criteriaPapillary dermal vesselsMononuclear inflammatory infiltrateHistologic diagnostic criteriaLarge case seriesSpecific histologic criteriaWnt/ß-cateninClinicopathologic studyPerifollicular fibrosisCase seriesHistopathologic evidenceInflammatory infiltrateUnderdiagnosed entityFibrohistiocytic originInflamed lesionsHistologic criteriaDermal vesselsHistopathologic entityDermatopathology laboratoryDermatofibromaß-cateninPossible alterationsFibrosis
2014
p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma
Alomari AK, Glusac EJ, McNiff JM. p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma. Journal Of Cutaneous Pathology 2014, 41: 839-845. PMID: 25263848, DOI: 10.1111/cup.12388.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaAtypical fibroxanthomaCell carcinomaNon-cutaneous squamous-cell carcinomaNuclear stainingNon-squamous tumorsGiant cell tumorCutaneous leiomyosarcomaExclusive nuclear stainingCell tumorsDiagnostic challengeCytokeratin MNF116Focal stainingMNF116Tumor cytoplasmLeiomyosarcomaDiagnostic accuracyControl casesSoft tissueSpecific markersP40StainingCarcinomaP63Tumors
2012
Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases
Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-323. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaPerineural involvementDesmoplastic stromaMicrocystic adnexal carcinomaBasal cell carcinomaBenign epithelial proliferationsP75 neurotrophin receptorMiddle-aged womenBenign follicular tumorsCK20-positive cellsSmall dermal nervesAdnexal carcinomaCell carcinomaTumor recurrenceTypical presentationBasaloid epitheliumDermal nervesPerineural spaceNeurotrophin receptorBasaloid cellsEpithelial proliferationDermal proliferationDiffuse expressionFollicular tumorsPatients
2004
Primary Cutaneous B-Cell Lymphoma Treated With Radiotherapy: A Comparison of the European Organization for Research and Treatment of Cancer and the WHO Classification Systems
Smith BD, Glusac EJ, McNiff JM, Smith GL, Heald PW, Cooper DL, Wilson LD. Primary Cutaneous B-Cell Lymphoma Treated With Radiotherapy: A Comparison of the European Organization for Research and Treatment of Cancer and the WHO Classification Systems. Journal Of Clinical Oncology 2004, 22: 634-639. PMID: 14966086, DOI: 10.1200/jco.2004.08.044.Peer-Reviewed Original ResearchConceptsCutaneous B-cell lymphomaPrimary cutaneous B-cell lymphomaLarge B-cellInitial biopsy specimensB-cell lymphomaFollicle center cellsB cellsOverall survivalBiopsy specimensFive-year relapse-free survivalEuropean OrganizationFive-year overall survivalCenter cellsRelapse-free survivalWHO classification systemExtracutaneous diseaseLocal radiotherapyIndolent coursePrimary outcomeInitial treatmentTreatment of cancerHistopathologic subtypePathologic classificationNoncutaneous sitesDLB
2001
Cerebral Mass Due to Neurocutaneous Melanosis: Eight Years Later
Schaffer J, McNiff J, Bolognia J. Cerebral Mass Due to Neurocutaneous Melanosis: Eight Years Later. Pediatric Dermatology 2001, 18: 369-377. PMID: 11737677, DOI: 10.1046/j.1525-1470.2001.01961.x.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsBrain NeoplasmsChildHumansMagnetic Resonance ImagingMaleMelanosisNeurocutaneous SyndromesNevus, PigmentedSkin NeoplasmsConceptsCongenital melanocytic neviGiant congenital melanocytic nevusMagnetic resonance imagingNeurocutaneous melanosisCentral nervous system involvementExcellent long-term outcomesMedium-sized congenital melanocytic nevusMultiple satellite neviSymptomatic neurocutaneous melanosisNervous system involvementAbsence of malignancyLong-term outcomesRight temporal lobePotential surgical interventionAge 5 monthsAge 10 monthsT1-weighted imagesPerivascular collectionsSatellite neviAsymptomatic patientsEarly imagingSurgical interventionSurgical specimenSystem involvementHistologic examination
2000
Under The Microscope Surgeons, Pathologists, and Melanocytic Nevi
Lazova R, McNiff J, Glusac E. Under The Microscope Surgeons, Pathologists, and Melanocytic Nevi. Clinics In Plastic Surgery 2000, 27: 323-329. PMID: 10941556, DOI: 10.1016/s0094-1298(20)32731-0.Peer-Reviewed Original ResearchPrimary cutaneous follicle center cell lymphoma with follicular growth pattern
Cerroni L, Arzberger E, Puütz B, Hoüfler G, Metze D, Sander C, Rose C, Wolf P, Ruütten A, McNiff J, Kerl H. Primary cutaneous follicle center cell lymphoma with follicular growth pattern. Blood 2000, 95: 3922-3928. PMID: 10845929, DOI: 10.1182/blood.v95.12.3922.Peer-Reviewed Original ResearchConceptsB-cell infiltratesFollicular growth patternGerminal centersPrimary cutaneous follicle center cell lymphomaCutaneous follicle center cell lymphomaPrimary cutaneous follicular lymphomaCutaneous B-cell lymphomaCutaneous follicular lymphomaSame monoclonal populationFollicle center cell lymphomaCutaneous B-cell infiltratesBone marrow biopsyReactive germinal centersB-cell lymphomaFollicle center cellsBcl-2 protein expressionExtracutaneous spreadStaging investigationsPolymerase chain reaction analysisMarrow biopsyImmunophenotypic criteriaNeoplastic folliclesFollicular patternMonoclonal rearrangementSkin lesions