2023
Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells
Sacirbegovic F, Günther M, Greco A, Zhao D, Wang X, Zhou M, Rosenberger S, Oberbarnscheidt M, Held W, McNiff J, Jain D, Höfer T, Shlomchik W. Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells. Immunity 2023, 56: 369-385.e6. PMID: 36720219, PMCID: PMC10182785, DOI: 10.1016/j.immuni.2023.01.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGraft vs Host DiseaseHematopoietic Stem Cell TransplantationMiceT-LymphocytesTransplantation, HomologousConceptsHost diseaseAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationChronic antigen stimulationStem cell transplantationAlloreactive effectorsAdoptive transferCell transplantationΑβ TAntigen stimulationCell exhaustionGVHDRecipient tissuesEffector poolMajor causeCell clonesTarget tissuesAffected tissuesDiseaseGraftTissueTCF-1CellsDiseased tissuesMorbidity
2001
Pathogenesis of autoimmunity in αβ T cell-deficient lupus-prone mice
Peng S, Cappadona J, Mcniff J, Madaio M, Owen M, Hayday A, Craft J. Pathogenesis of autoimmunity in αβ T cell-deficient lupus-prone mice. Clinical & Experimental Immunology 2001, 111: 107-116. PMID: 9472669, PMCID: PMC1904839, DOI: 10.1046/j.1365-2249.1998.00424.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmunityKidney DiseasesLupus VulgarisMiceReceptors, Antigen, T-Cell, alpha-betaSkinT-LymphocytesConceptsT cell-dependent mechanismCell-dependent mechanismEnd-organ diseaseImmune complex depositionGammadelta T cellsRenal diseaseMurine lupusComplex depositionT cellsMRL miceSkin lesionsComplement fixationT-cell-deficient animalsEnd-organ damageLupus-prone miceNon-autoimmune micePathogenesis of autoimmunityYears of ageHumoral autoimmunityLupus lesionsAutoantibody productionSkin diseasesSkin injuryTCR alphaFas antigenSelective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease
Liu J, Anderson B, Robert M, McNiff J, Emerson S, Shlomchik W, Shlomchik M. Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease. Blood 2001, 98: 3367-3375. PMID: 11719376, DOI: 10.1182/blood.v98.12.3367.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DeathCytokinesDisease Models, AnimalFlow CytometryGanciclovirGraft vs Host DiseaseGraft vs Leukemia EffectHematopoiesisHematopoietic Stem CellsInterleukin-2Interleukin-4Lymphocyte SubsetsMaleMiceMice, TransgenicPromoter Regions, GeneticSimplexvirusSpleenThymidine KinaseThymus GlandT-LymphocytesWeight GainConceptsDonor T cellsT cellsT2 cellsGVHD reactionsHost diseaseInterleukin-2Herpes simplex virus thymidine kinase gene transductionAllogeneic stem cell transplantationCytokine-producing T cellsPrevention of GVHDStem cell transplantationReversal of diseaseT cell deletionLater time pointsAcute graftCytokine polarizationOngoing GVHDClinical GVHDAntibody infusionPeak diseaseClinical effectsCell transplantationIL-4 promoterGVHDDeficient mice
2000
Human TNF Can Induce Nonspecific Inflammatory and Human Immune-Mediated Microvascular Injury of Pig Skin Xenografts in Immunodeficient Mouse Hosts
Kirkiles-Smith N, Tereb D, Kim R, McNiff J, Schechner J, Lorber M, Pober J, Tellides G. Human TNF Can Induce Nonspecific Inflammatory and Human Immune-Mediated Microvascular Injury of Pig Skin Xenografts in Immunodeficient Mouse Hosts. The Journal Of Immunology 2000, 164: 6601-6609. PMID: 10843720, DOI: 10.4049/jimmunol.164.12.6601.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAdultAnimalsCell Adhesion MoleculesDose-Response Relationship, ImmunologicDrug SynergismEndothelium, VascularGraft RejectionHistocompatibility AntigensHumansInterferon-gammaMiceMice, Inbred C57BLMice, SCIDMicrocirculationSevere Combined ImmunodeficiencySkin TransplantationSwineT-LymphocytesTransplantation, HeterologousTumor Necrosis Factor-alphaUp-RegulationConceptsHuman T-cell infiltrationPig skin xenograftsT cell infiltrationSkin xenograftsCell infiltrationHuman TNFIFN-gammaE-selectinT cell-mediated rejectionEndothelial cellsAdhesion moleculesCytokine-mediated injuryNonspecific inflammatory damagePig skin graftsCell-mediated rejectionAppropriate therapeutic targetsImmunodeficient mouse modelPorcine E-selectinEndothelial adhesion moleculesPorcine IFN-gammaClass II moleculesHuman skin allograftsMHC class IPorcine endothelial cellsImmunodeficient mouse hosts
1998
Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin
Murray A, Schechner J, Epperson D, Sultan P, McNiff J, Hughes C, Lorber M, Askenase P, Pober J. Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin. American Journal Of Pathology 1998, 153: 627-638. PMID: 9708821, PMCID: PMC1852982, DOI: 10.1016/s0002-9440(10)65604-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCD8-Positive T-LymphocytesCyclosporineDrug Therapy, CombinationEndothelium, VascularEnzyme-Linked Immunosorbent AssayFlow CytometryGenes, MHC Class IIGraft RejectionHumansImmunosuppressive AgentsKeratinocytesMiceMice, SCIDMicrocirculationPolyenesSirolimusSkinSkin TransplantationT-LymphocytesTransplantation, HomologousVascular Cell Adhesion Molecule-1ConceptsPeripheral blood mononuclear cellsHuman peripheral blood mononuclear cellsSkin allograft modelMicrovascular injuryT cellsCell infiltrateAllograft modelWhole peripheral blood mononuclear cellsT cell-dependent mechanismT cell-mediated rejectionHuman natural killer cellsSCID/beige miceEndothelial cell sloughingT Cell-MediatedCell-mediated rejectionCombination of cyclosporineT-cell infiltratesCell-dependent mechanismMononuclear cell infiltrateNatural killer cellsMononuclear cell infiltrationBlood mononuclear cellsSkin graft modelHuman immune responseImmunoglobulin G antibodies
1997
Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras
Sultan P, Schechner J, McNiff J, Hochman P, Hughes C, Lorber M, Askenase P, Pober J. Blockade of CD2-LFA-3 interactions protects human skin allografts in immunodeficient mouse/human chimeras. Nature Biotechnology 1997, 15: 759-762. PMID: 9255790, DOI: 10.1038/nbt0897-759.Peer-Reviewed Original ResearchConceptsSkin graftsLFA-3Human T-cell infiltrationIsotype-matched control antibodyT cell infiltrationSkin graft rejectionHuman skin graftsHuman skin allograftsCD2-LFA-3 interactionHuman LFA-3Microvascular injuryGraft rejectionLeukocyte infiltrationSkin allograftsImmune modulatorsControl antibodyInjury modelImmunodeficient miceImmune reactionsMouse/human chimeraMurine mAbsCD2 interactionPrincipal ligandGraftInjury
1996
Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder.
McNiff J, Cooper D, Howe G, Crotty P, Tallini G, Crouch J, Eisen R. Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder. JAMA Dermatology 1996, 132: 1464-70. PMID: 8961876, DOI: 10.1001/archderm.132.12.1464.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedB-LymphocytesCell DivisionClone CellsGene Rearrangement, beta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGenes, ImmunoglobulinHerpesvirus 4, HumanHumansImmunoglobulin Heavy ChainsImmunophenotypingIn Situ HybridizationLung DiseasesLymphomatoid GranulomatosisMaleMiddle AgedPolymerase Chain ReactionReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaRetrospective StudiesRNA, ViralSkin DiseasesT-LymphocytesConceptsLymphomatoid granulomatosisEpstein-Barr virusEBV RNAB cellsLymphoproliferative disordersPolymerase chain reactionT-cell lymphoproliferative disorderEpstein-Barr virus RNAB-cell lymphoproliferative disordersClonality of lymphocytesT-cell infiltratesAcademic referral centerImmunoglobulin heavy chain gene rearrangementT-cell markersGene rearrangementsT-cell receptor betaChain reactionHeavy chain gene rearrangementClonal immunoglobulin heavy chain gene rearrangementT-cell receptor genesClonal gene rearrangementsChain gene rearrangementAngiocentric infiltratesImmunoglobulin heavy chain geneReferral center