1999
Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line.
Grossman D, McNiff J, Li F, Altieri D. Expression of the apoptosis inhibitor, survivin, in nonmelanoma skin cancer and gene targeting in a keratinocyte cell line. Laboratory Investigation 1999, 79: 1121-6. PMID: 10496530.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaBasal cell carcinomaNonmelanoma skin cancerHypertrophic actinic keratosisCell carcinomaSkin cancerKeratinocyte cell lineCutaneous squamous cell carcinomaG0/G1 fractionCell linesAdvanced diseaseBowen's diseaseActinic keratosisSurvivin dominant-negative mutantPremalignant lesionsTherapeutic targetingApoptosis inhibitor survivinSurvivin expressionFlow cytometryWestern blottingDecreased levelsMorpheaform subtypesCancerSpontaneous apoptosisDiseaseExpression and localization of thymidine phosphorylase/platelet‐derived endothelial cell growth factor in skin and cutaneous tumors
Asgari M, Haggerty J, McNiff J, Milstone L, Schwartz P. Expression and localization of thymidine phosphorylase/platelet‐derived endothelial cell growth factor in skin and cutaneous tumors. Journal Of Cutaneous Pathology 1999, 26: 287-294. PMID: 10472757, DOI: 10.1111/j.1600-0560.1999.tb01846.x.Peer-Reviewed Original ResearchConceptsPlatelet-derived endothelial cell growth factorThymidine phosphorylase/platelet-derived endothelial cell growth factorPD-ECGF expressionEndothelial cell growth factorCutaneous tumorsPD-ECGFCell carcinomaCell growth factorGrowth factorSquamous cell carcinomaMerkel cell carcinomaBasal cell carcinomaVariety of tumorsCell of originNuclei of keratinocytesFollicular infundibulumTumor degreeDifferentiation of keratinocytesEccrine poromaImmunohistochemical analysisPositive stainingIntradermal nevusNormal skinTumorsIntense staining
1998
Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin
Murray A, Schechner J, Epperson D, Sultan P, McNiff J, Hughes C, Lorber M, Askenase P, Pober J. Dermal Microvascular Injury in the Human Peripheral Blood Lymphocyte Reconstituted-Severe Combined Immunodeficient (HuPBL-SCID) Mouse/Skin Allograft Model Is T Cell Mediated and Inhibited by a Combination of Cyclosporine and Rapamycin. American Journal Of Pathology 1998, 153: 627-638. PMID: 9708821, PMCID: PMC1852982, DOI: 10.1016/s0002-9440(10)65604-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesCD8-Positive T-LymphocytesCyclosporineDrug Therapy, CombinationEndothelium, VascularEnzyme-Linked Immunosorbent AssayFlow CytometryGenes, MHC Class IIGraft RejectionHumansImmunosuppressive AgentsKeratinocytesMiceMice, SCIDMicrocirculationPolyenesSirolimusSkinSkin TransplantationT-LymphocytesTransplantation, HomologousVascular Cell Adhesion Molecule-1ConceptsPeripheral blood mononuclear cellsHuman peripheral blood mononuclear cellsSkin allograft modelMicrovascular injuryT cellsCell infiltrateAllograft modelWhole peripheral blood mononuclear cellsT cell-dependent mechanismT cell-mediated rejectionHuman natural killer cellsSCID/beige miceEndothelial cell sloughingT Cell-MediatedCell-mediated rejectionCombination of cyclosporineT-cell infiltratesCell-dependent mechanismMononuclear cell infiltrateNatural killer cellsMononuclear cell infiltrationBlood mononuclear cellsSkin graft modelHuman immune responseImmunoglobulin G antibodies