2001
Deficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level
Chan O, Paliwal V, McNiff J, Park S, Bendelac A, Shlomchik M. Deficiency in β2-Microglobulin, But Not CD1, Accelerates Spontaneous Lupus Skin Disease While Inhibiting Nephritis in MRL-Faslpr Mice: An Example of Disease Regulation at the Organ Level. The Journal Of Immunology 2001, 167: 2985-2990. PMID: 11509649, DOI: 10.4049/jimmunol.167.5.2985.Peer-Reviewed Original ResearchConceptsSkin diseasesT cell-dependent mechanismMRL/lpr miceLupus skin diseaseLupus skin lesionsMRL-Faslpr miceNonclassical MHC moleculesTarget organ diseaseCell-dependent mechanismTarget organ levelRegulation of autoimmunitySecondary lymphoid tissuesAutoreactive lymphocytesMurine lupusLpr miceSystemic diseaseAutoimmune diseasesLymphoid tissueOrgan diseaseDeficient miceT cellsSkin lesionsEnd organsOrgan levelImmune system
1999
Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells
Shlomchik W, Couzens M, Tang C, McNiff J, Robert M, Liu J, Shlomchik M, Emerson S. Prevention of Graft Versus Host Disease by Inactivation of Host Antigen-Presenting Cells. Science 1999, 285: 412-415. PMID: 10411505, DOI: 10.1126/science.285.5426.412.Peer-Reviewed Original ResearchConceptsAntigen-presenting cellsAllogeneic bone marrow transplantationBone marrow transplantationHost diseaseMarrow transplantationT cellsMurine allogeneic bone marrow transplantation modelAllogeneic bone marrow transplantation modelHost-derived antigen-presenting cellsGraft Versus Host DiseaseHost antigen-presenting cellsDonor antigen-presenting cellsVersus Host DiseaseDonor T cellsAllogeneic T cellsBone marrow transplantation modelAlloimmune attackHost antigensTransplantation modelImportant toxicityNeoplastic diseaseDiseaseGraftTransplantationHost tissues