2023
Association of Somatic ATP2A2 Damaging Variants With Grover Disease
Seli D, Ellis K, Goldust M, Shah K, Hu R, Zhou J, McNiff J, Choate K. Association of Somatic ATP2A2 Damaging Variants With Grover Disease. JAMA Dermatology 2023, 159: 745-749. PMID: 37195706, PMCID: PMC10193258, DOI: 10.1001/jamadermatol.2023.1139.Peer-Reviewed Original ResearchConceptsGrover's diseaseGD tissuesSomatic single nucleotide variantsControl tissuesRetrospective case seriesCase series studyAnnotation-dependent depletion scoreConsecutive patientsCase seriesKidney failureHistopathologic findingsAcantholytic disordersOrgan transplantationMAIN OUTCOMEBiopsy tissueSeries studyDarier's diseaseClinical diagnosisParticipant's DNAOlder individualsTissue DNADiseaseDisordersPatientsBiopsy
2021
Epidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation
Li P, Barbieri A, Walther Z, McNiff J, Panse G. Epidermotropic metastasis of squamous cell carcinoma of the tonsil: A case report with molecular confirmation. Journal Of Cutaneous Pathology 2021, 48: 1514-1519. PMID: 34302376, DOI: 10.1111/cup.14108.Peer-Reviewed Case Reports and Technical NotesConceptsSquamous cell carcinomaOropharyngeal squamous cell carcinomaCell carcinomaDe novo squamous cell carcinomaPrimary oropharyngeal squamous cell carcinomaTonsillar squamous cell carcinomaTargetable genetic aberrationsLesion biopsy specimensSkin biopsy specimenSkin lesion biopsy specimensMetastatic diseaseEpidermal involvementEpidermotropic metastasesMetastatic lesionsPoor prognosisBiopsy specimenCase reportClinical historyBiopsy specimensSecondary diseaseSkin lesionsTumor originMetastatic specimensMetastasisNeck skinNew bullous lesions in a 72-year-old woman
Mendoza H, Goodwin J, Gehlhausen J, Odell I, McNiff J, Gnanapandithan K. New bullous lesions in a 72-year-old woman. Cleveland Clinic Journal Of Medicine 2021, 88: 319-324. PMID: 34078615, DOI: 10.3949/ccjm.88a.20180.Peer-Reviewed Case Reports and Technical NotesLichenoid dermatoses with pseudomelanocytic nests vs inflamed melanoma in situ: A comparative study
Panse G, McNiff JM. Lichenoid dermatoses with pseudomelanocytic nests vs inflamed melanoma in situ: A comparative study. Journal Of Cutaneous Pathology 2021, 48: 745-749. PMID: 33350494, DOI: 10.1111/cup.13945.Peer-Reviewed Original ResearchConceptsPseudomelanocytic nestsLichenoid dermatosesDermoepidermal junctionHistopathological featuresPagetoid scatterCytologic atypiaDifferent histopathological featuresSun-damaged skinSignificant cytologic atypiaLichenoid inflammationSolitary melanocytesLichenoid keratosisClinicopathological correlationBiopsy specimensNon-melanocytic lesionsDiagnostic pitfallsAtypical melanocytesDermatosesSingle melanocytesAtypiaMelanomaMelanocytesConfluent growthBenign process
2020
Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein
Ko CJ, Harigopal M, Gehlhausen JR, Bosenberg M, McNiff JM, Damsky W. Discordant anti‐SARS‐CoV‐2 spike protein and RNA staining in cutaneous perniotic lesions suggests endothelial deposition of cleaved spike protein. Journal Of Cutaneous Pathology 2020, 48: 47-52. PMID: 32895985, DOI: 10.1111/cup.13866.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 spike proteinCOVID toesEccrine epitheliumEndothelial cellsSkin biopsiesSpike proteinReverse transcriptase polymerase chain reaction testingSARS-CoV-2 antibodiesPolymerase chain reaction testingSARS-CoV-2 RNAPotential pathogenetic mechanismsPositive immunohistochemical labelingSARS-CoV-2Endothelial depositionPathogenetic mechanismsImmunohistochemical stainingReaction testingImmunohistochemical labelingEccrine glandsRNA ISHImmunohistochemistrySpike RNAGold standardTissue sectionsBiopsyPerniosis during the COVID‐19 pandemic: Negative anti‐SARS‐CoV‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV‐2
Ko CJ, Harigopal M, Damsky W, Gehlhausen JR, Bosenberg M, Patrignelli R, McNiff JM. Perniosis during the COVID‐19 pandemic: Negative anti‐SARS‐CoV‐2 immunohistochemistry in six patients and comparison to perniosis before the emergence of SARS‐CoV‐2. Journal Of Cutaneous Pathology 2020, 47: 997-1002. PMID: 32745281, PMCID: PMC7436569, DOI: 10.1111/cup.13830.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 nucleocapsid proteinPerivascular lymphocytesImmunohistochemical stainingCOVID-19 pandemicSARS-CoV-2 immunohistochemistryNucleocapsid proteinSARS-CoV-2Inflammatory lesionsHistopathologic findingsIntravascular occlusionMicroscopic findingsPerniosisIntravascular materialLymphocytesLesionsPatientsStainingPandemicSuch casesCuffingHistopathologyCasesImmunohistochemistryFindingsProteinCutaneous Involvement in Plasma Cell Myeloma
Panse G, Subtil A, McNiff JM, Glusac EJ, Ko CJ, Galan A, Myung P, Xu ML. Cutaneous Involvement in Plasma Cell Myeloma. American Journal Of Clinical Pathology 2020, 155: 106-116. PMID: 32885235, DOI: 10.1093/ajcp/aqaa122.Peer-Reviewed Original ResearchConceptsPlasma cell myelomaCutaneous involvementSquamous cell carcinomaAmyloid depositionCell carcinomaCell myelomaCases of PCMBone marrow involvementCyclin D1 immunoreactivityDisease-related deathLight chain restrictionCCND1 gene rearrangementMarrow involvementSkin involvementClinicopathologic featuresCytomorphologic spectrumCutaneous lesionsPoor outcomeCommon immunophenotypeChain restrictionClinical dataCytogenetic findingsOlder individualsGene rearrangementsMyelomaEpidermolytic Acanthoma: Findings of a Large Retrospective Study
Roy SF, McNiff JM. Epidermolytic Acanthoma: Findings of a Large Retrospective Study. International Journal Of Gynecological Pathology 2020, 40: e4-e4. PMID: 33290356, DOI: 10.1097/pgp.0000000000000672.Peer-Reviewed Original Research
2019
Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern
Roy SF, Ko CJ, Moeckel GW, Mcniff JM. Hypergranulotic dyscornification: 30 cases of a striking epithelial reaction pattern. Journal Of Cutaneous Pathology 2019, 46: 742-747. PMID: 31157457, DOI: 10.1111/cup.13522.Peer-Reviewed Original ResearchConceptsBenign keratosesDistinctive histopathologic findingsHistological reaction patternEpidermolytic hyperkeratosisReaction patternsBowen's diseaseRetrospective reviewMean ageProminent granular layerHistopathologic findingsEpidermoid cystKeratin immunohistochemistryClinical impressionSeborrheic keratosisPositive stainingNeck areaAbnormal keratinizationKeratohyaline granulesUnique reaction patternReproducible findingsKeratosesCytoplasmic areaGranular layerHyperkeratosisPrevious reportsObservational Study Examining the Diagnostic Practice of Ki67 Staining for Melanocytic Lesions
Vyas NS, Charifa A, Desman GT, Goldberg M, Singh R, Phelps RG, McNiff JM. Observational Study Examining the Diagnostic Practice of Ki67 Staining for Melanocytic Lesions. American Journal Of Dermatopathology 2019, Publish Ahead of Print: &na;. PMID: 31233404, DOI: 10.1097/dad.0000000000001379.Peer-Reviewed Original ResearchMultinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria
Roy SF, Dong D, Myung P, McNiff JM. Multinucleate cell angiohistiocytoma: A clinicopathologic study of 62 cases and proposed diagnostic criteria. Journal Of Cutaneous Pathology 2019, 46: 563-569. PMID: 30927287, DOI: 10.1111/cup.13463.Peer-Reviewed Original ResearchConceptsMultinucleate cell angiohistiocytomaFollicular inductionDiagnostic criteriaPapillary dermal vesselsMononuclear inflammatory infiltrateHistologic diagnostic criteriaLarge case seriesSpecific histologic criteriaWnt/ß-cateninClinicopathologic studyPerifollicular fibrosisCase seriesHistopathologic evidenceInflammatory infiltrateUnderdiagnosed entityFibrohistiocytic originInflamed lesionsHistologic criteriaDermal vesselsHistopathologic entityDermatopathology laboratoryDermatofibromaß-cateninPossible alterationsFibrosis
2014
p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma
Alomari AK, Glusac EJ, McNiff JM. p40 is a more specific marker than p63 for cutaneous poorly differentiated squamous cell carcinoma. Journal Of Cutaneous Pathology 2014, 41: 839-845. PMID: 25263848, DOI: 10.1111/cup.12388.Peer-Reviewed Original ResearchConceptsSquamous cell carcinomaAtypical fibroxanthomaCell carcinomaNon-cutaneous squamous-cell carcinomaNuclear stainingNon-squamous tumorsGiant cell tumorCutaneous leiomyosarcomaExclusive nuclear stainingCell tumorsDiagnostic challengeCytokeratin MNF116Focal stainingMNF116Tumor cytoplasmLeiomyosarcomaDiagnostic accuracyControl casesSoft tissueSpecific markersP40StainingCarcinomaP63Tumors
2012
Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases
Jedrych J, Leffell D, McNiff JM. Desmoplastic trichoepithelioma with perineural involvement: a series of seven cases. Journal Of Cutaneous Pathology 2012, 39: 317-323. PMID: 22335590, DOI: 10.1111/j.1600-0560.2012.01876.x.Peer-Reviewed Original ResearchConceptsDesmoplastic trichoepitheliomaPerineural involvementDesmoplastic stromaMicrocystic adnexal carcinomaBasal cell carcinomaBenign epithelial proliferationsP75 neurotrophin receptorMiddle-aged womenBenign follicular tumorsCK20-positive cellsSmall dermal nervesAdnexal carcinomaCell carcinomaTumor recurrenceTypical presentationBasaloid epitheliumDermal nervesPerineural spaceNeurotrophin receptorBasaloid cellsEpithelial proliferationDermal proliferationDiffuse expressionFollicular tumorsPatients
2004
Primary Cutaneous B-Cell Lymphoma Treated With Radiotherapy: A Comparison of the European Organization for Research and Treatment of Cancer and the WHO Classification Systems
Smith BD, Glusac EJ, McNiff JM, Smith GL, Heald PW, Cooper DL, Wilson LD. Primary Cutaneous B-Cell Lymphoma Treated With Radiotherapy: A Comparison of the European Organization for Research and Treatment of Cancer and the WHO Classification Systems. Journal Of Clinical Oncology 2004, 22: 634-639. PMID: 14966086, DOI: 10.1200/jco.2004.08.044.Peer-Reviewed Original ResearchConceptsCutaneous B-cell lymphomaPrimary cutaneous B-cell lymphomaLarge B-cellInitial biopsy specimensB-cell lymphomaFollicle center cellsB cellsOverall survivalBiopsy specimensFive-year relapse-free survivalEuropean OrganizationFive-year overall survivalCenter cellsRelapse-free survivalWHO classification systemExtracutaneous diseaseLocal radiotherapyIndolent coursePrimary outcomeInitial treatmentTreatment of cancerHistopathologic subtypePathologic classificationNoncutaneous sitesDLB
2000
Primary cutaneous follicle center cell lymphoma with follicular growth pattern
Cerroni L, Arzberger E, Puütz B, Hoüfler G, Metze D, Sander C, Rose C, Wolf P, Ruütten A, McNiff J, Kerl H. Primary cutaneous follicle center cell lymphoma with follicular growth pattern. Blood 2000, 95: 3922-3928. PMID: 10845929, DOI: 10.1182/blood.v95.12.3922.Peer-Reviewed Original ResearchConceptsB-cell infiltratesFollicular growth patternGerminal centersPrimary cutaneous follicle center cell lymphomaCutaneous follicle center cell lymphomaPrimary cutaneous follicular lymphomaCutaneous B-cell lymphomaCutaneous follicular lymphomaSame monoclonal populationFollicle center cell lymphomaCutaneous B-cell infiltratesBone marrow biopsyReactive germinal centersB-cell lymphomaFollicle center cellsBcl-2 protein expressionExtracutaneous spreadStaging investigationsPolymerase chain reaction analysisMarrow biopsyImmunophenotypic criteriaNeoplastic folliclesFollicular patternMonoclonal rearrangementSkin lesions
1999
Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma
Grossman D, McNiff J, Li F, Altieri D. Expression and Targeting of the Apoptosis Inhibitor, Survivin, in Human Melanoma. Journal Of Investigative Dermatology 1999, 113: 1076-1081. PMID: 10594755, DOI: 10.1046/j.1523-1747.1999.00776.x.Peer-Reviewed Original ResearchConceptsInvasive malignant melanomaMalignant melanomaDominant negative mutantCultured normal human melanocytesCell cycle progressionApoptosis inhibitor Bcl-2G1 DNA contentNormal human melanocytesSurvivin expressionApoptosis inhibitor survivinApoptosis regulationEndogenous survivinNegative mutantTwo-color flow cytometryGenotoxic stimuliMalignant melanoma cell linesSurvivin dominant-negative mutantCycle progressionMetastatic malignant melanomaApoptosis inhibitorMelanoma cell linesHuman melanocytesMIB-1 stainingApoptosis inhibitionCases of nevusMorphea Limited to the Superficial Reticular Dermis: An Underrecognized Histologic Phenomenon
McNiff J, Glusac E, Lazova R, Carroll C. Morphea Limited to the Superficial Reticular Dermis: An Underrecognized Histologic Phenomenon. American Journal Of Dermatopathology 1999, 21: 315-319. PMID: 10446770, DOI: 10.1097/00000372-199908000-00001.Peer-Reviewed Original ResearchConceptsLichen sclerosus et atrophicusSuperficial reticular dermisSuperficial dermisReticular dermisSpindle cellsDermal dendritic cellsCollagen bundlesTypical histologic featuresImmune accessory cellsSclerosus et atrophicusDermal spindle cellsCases of morpheaDeep reticular dermisElastic fibersDermal elastic fibersDendritic cellsHistologic featuresIndurated skinUnknown etiologyAdditional biopsiesEt atrophicusMorpheaHistologic phenomenonDeep dermisAccessory cellsImmunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma
McNiff J, Eisen R, Glusac E. Immunohistochemical comparison of cutaneous lymphadenoma, trichoblastoma, and basal cell carcinoma: support for classification of lymphadenoma as a variant of trichoblastoma. Journal Of Cutaneous Pathology 1999, 26: 119-124. PMID: 10235376, DOI: 10.1111/j.1600-0560.1999.tb01815.x.Peer-Reviewed Original ResearchConceptsBasal cell carcinomaVariant of trichoblastomaCutaneous lymphadenomaCell carcinomaLangerhans cellsNodular basal cell carcinomaCK20-positive Merkel cellsS100-positive cellsBcl-2CD30-positive cellsCharacteristic immunohistochemical findingsSimilar staining patternLymphoid infiltratesImmunohistochemical findingsStromal stainingTumor groupEpithelial tumorsImmunohistochemical comparisonUncertain histogenesisMerkel cellsTrichoblastomaS100 proteinCD1aLymphadenomaStaining patternEpithelioid Cell Histiocytoma: A Simulant of Vascular and Melanocytic Neoplasms
Glusac E, McNiff J. Epithelioid Cell Histiocytoma: A Simulant of Vascular and Melanocytic Neoplasms. American Journal Of Dermatopathology 1999, 21: 1-7. PMID: 10027517, DOI: 10.1097/00000372-199902000-00001.Peer-Reviewed Original Research
1996
Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder.
McNiff J, Cooper D, Howe G, Crotty P, Tallini G, Crouch J, Eisen R. Lymphomatoid granulomatosis of the skin and lung. An angiocentric T-cell-rich B-cell lymphoproliferative disorder. JAMA Dermatology 1996, 132: 1464-70. PMID: 8961876, DOI: 10.1001/archderm.132.12.1464.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedB-LymphocytesCell DivisionClone CellsGene Rearrangement, beta-Chain T-Cell Antigen ReceptorGene Rearrangement, gamma-Chain T-Cell Antigen ReceptorGenes, ImmunoglobulinHerpesvirus 4, HumanHumansImmunoglobulin Heavy ChainsImmunophenotypingIn Situ HybridizationLung DiseasesLymphomatoid GranulomatosisMaleMiddle AgedPolymerase Chain ReactionReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaRetrospective StudiesRNA, ViralSkin DiseasesT-LymphocytesConceptsLymphomatoid granulomatosisEpstein-Barr virusEBV RNAB cellsLymphoproliferative disordersPolymerase chain reactionT-cell lymphoproliferative disorderEpstein-Barr virus RNAB-cell lymphoproliferative disordersClonality of lymphocytesT-cell infiltratesAcademic referral centerImmunoglobulin heavy chain gene rearrangementT-cell markersGene rearrangementsT-cell receptor betaChain reactionHeavy chain gene rearrangementClonal immunoglobulin heavy chain gene rearrangementT-cell receptor genesClonal gene rearrangementsChain gene rearrangementAngiocentric infiltratesImmunoglobulin heavy chain geneReferral center