2001
Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease
Liu J, Anderson B, Robert M, McNiff J, Emerson S, Shlomchik W, Shlomchik M. Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease. Blood 2001, 98: 3367-3375. PMID: 11719376, DOI: 10.1182/blood.v98.12.3367.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DeathCytokinesDisease Models, AnimalFlow CytometryGanciclovirGraft vs Host DiseaseGraft vs Leukemia EffectHematopoiesisHematopoietic Stem CellsInterleukin-2Interleukin-4Lymphocyte SubsetsMaleMiceMice, TransgenicPromoter Regions, GeneticSimplexvirusSpleenThymidine KinaseThymus GlandT-LymphocytesWeight GainConceptsDonor T cellsT cellsT2 cellsGVHD reactionsHost diseaseInterleukin-2Herpes simplex virus thymidine kinase gene transductionAllogeneic stem cell transplantationCytokine-producing T cellsPrevention of GVHDStem cell transplantationReversal of diseaseT cell deletionLater time pointsAcute graftCytokine polarizationOngoing GVHDClinical GVHDAntibody infusionPeak diseaseClinical effectsCell transplantationIL-4 promoterGVHDDeficient mice
2000
Humanized In Vivo Model for Streptococcal Impetigo
Scaramuzzino D, McNiff J, Bessen D. Humanized In Vivo Model for Streptococcal Impetigo. Infection And Immunity 2000, 68: 2880-2887. PMID: 10768985, PMCID: PMC97500, DOI: 10.1128/iai.68.5.2880-2887.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDisease Models, AnimalFemaleHumansImpetigoMiceMice, SCIDSkinStreptococcal InfectionsStreptococcus pyogenesVirulenceConceptsStreptococcal impetigoVivo modelPattern AGross pathology scoresD strainsHuman neonatal foreskinEmm pattern ASevere infectionsEpidemiological findingsPathology scoresPurulent exudateSCID micePolymorphonuclear leukocytesPositive cocciNeonatal foreskinImpetigoC strainDays postinoculationMouse originVirulent strainGranular keratinocytesIntact epidermisStratum corneumCocciEpidermis