2001
Novel inactivating mutations of transforming growth factor‐β type I receptor gene in head‐and‐neck cancer metastases
Chen T, Yan W, Wells R, Rimm D, McNiff J, Leffell D, Reiss M. Novel inactivating mutations of transforming growth factor‐β type I receptor gene in head‐and‐neck cancer metastases. International Journal Of Cancer 2001, 93: 653-661. PMID: 11477574, DOI: 10.1002/ijc.1381.Peer-Reviewed Original ResearchMeSH KeywordsActivin Receptors, Type IAmino Acid SequenceDisease ProgressionEndoplasmic ReticulumFemaleHead and Neck NeoplasmsHumansMaleMolecular Sequence DataMutationNeoplasms, Glandular and EpithelialNeoplasms, Unknown PrimaryProtein Serine-Threonine KinasesReceptor, Transforming Growth Factor-beta Type IReceptors, Transforming Growth Factor betaSequence Homology, Amino AcidSignal TransductionTransforming Growth Factor betaConceptsT beta RNeck cancer metastasisTGF-beta signalingCancer metastasisBeta RTGF betaBeta signalingLate-stage diseaseHuman epithelial neoplasmsCorresponding primary tumorsBreast cancer metastasisFine needle aspiratesTGF-beta type I receptorNovel inactivating mutationsBeta type I receptorType I receptorStage diseaseCarcinoma cell linesPrimary tumorCell cycle arrestEpithelial neoplasmsCodon 387MetastasisI receptorHuman tumors
1999
A common human skin tumour is caused by activating mutations in β-catenin
Chan E, Gat U, McNiff J, Fuchs E. A common human skin tumour is caused by activating mutations in β-catenin. Nature Genetics 1999, 21: 410-413. PMID: 10192393, DOI: 10.1038/7747.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBeta CateninCytoskeletal ProteinsDeoxyribonucleases, Type II Site-SpecificDNA-Binding ProteinsGene FrequencyHair DiseasesHumansLymphoid Enhancer-Binding Factor 1Molecular Sequence DataMutationPilomatrixomaPolymerase Chain ReactionSequence Analysis, DNASkin NeoplasmsTrans-ActivatorsTranscription FactorsConceptsAdenomatous polyposis coliΒ-cateninLEF/TCFHair matrix cellsΒ-catenin/TCFHair follicle morphogenesisAmino-terminal segmentDownstream transcriptional activationMost colon cancersHuman skin tumorsActivated β-cateninTranscriptional activationCytoplasmic β-cateninTarget genesLEF-1Constitutive activationMatrix cellsWnt pathwayHuman pilomatricomasC-MycSkin tumorsCell tumorigenesisMutationsPolyposis coliBiochemical evidence