2016
MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells
Browne G, Dragon J, Hong D, Messier T, Gordon J, Farina N, Boyd J, VanOudenhove J, Perez A, Zaidi S, Stein J, Stein G, Lian J. MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells. Tumor Biology 2016, 37: 8825-8839. PMID: 26749280, PMCID: PMC4939137, DOI: 10.1007/s13277-015-4710-6.Peer-Reviewed Original ResearchConceptsMDA-MB-231 cellsBreast cancer progressionMiR-378Breast cancer cellsCancer progressionMMTV-PyMT transgenic mouse modelCancer cellsLuciferase reporter assaysMiRNA replacement therapyMDA-MB-231 human breast cancer cellsBreast cancerTranscription factorsNumerous miRNAsEctopic expressionRegulatory pathwaysUntranslated regionMicroarray profilingReporter assaysHuman breast cancer cellsTriple-negative MDA-MB-231Breast cancer cell line MCF7Human breast cancer cell line MCF7Cell migrationRUNX1 expressionNormal hematopoiesis
2011
PSA regulates androgen receptor expression in prostate cancer cells
Saxena P, Trerotola M, Wang T, Li J, Sayeed A, VanOudenhove J, Adams D, FitzGerald T, Altieri D, Languino L. PSA regulates androgen receptor expression in prostate cancer cells. The Prostate 2011, 72: 769-776. PMID: 21956655, PMCID: PMC3404455, DOI: 10.1002/pros.21482.Peer-Reviewed Original ResearchConceptsProstate-specific antigenAndrogen receptorC4-2B cellsShort hairpin RNAPrCa cellsAndrogen-independent cell linesAndrogen receptor expressionProtein levelsAR transcriptional activityAR protein levelsAR mRNA levelsProstate cancer progressionProstate cancer cellsTransient siRNA knockdownStable short hairpin RNAAR activatorsPSA levelsAR expressionEffect of downregulationPhosphorylation of SrcSerum biomarkersAR mRNAReceptor expressionAR levelsReal-time PCR