2024
Effectiveness of glucose-lowering medications on cardiovascular outcomes in patients with type 2 diabetes at moderate cardiovascular risk
McCoy R, Herrin J, Swarna K, Deng Y, Kent D, Ross J, Umpierrez G, Galindo R, Crown W, Borah B, Montori V, Brito J, Neumiller J, Mickelson M, Polley E. Effectiveness of glucose-lowering medications on cardiovascular outcomes in patients with type 2 diabetes at moderate cardiovascular risk. Nature Cardiovascular Research 2024, 3: 431-440. PMID: 38846711, PMCID: PMC11156225, DOI: 10.1038/s44161-024-00453-9.Peer-Reviewed Original ResearchAdverse cardiovascular eventsGlucose-lowering medicationsType 2 diabetesCardiovascular diseaseGLP-1RACardiovascular eventsGlucagon-like peptide-1 receptor agonistsSodium-glucose cotransporter 2 inhibitorsPeptide-1 receptor agonistsDipeptidyl peptidase-4 inhibitorsPeptidase-4 inhibitorsRetrospective cohort studyCardiovascular disease risk reductionGlucose-lowering agentsModerate cardiovascular riskCardiovascular risk reductionReceptor agonistsEffects of glucose-lowering medicationsRisk reductionCardiovascular riskCohort studyCardiovascular outcomesHigh riskBaseline riskModerate riskHealthy immigrant community study protocol: A randomized controlled trial of a social network intervention for cardiovascular risk reduction among Hispanic and Somali adults
Wieland M, Molina L, Goodson M, Capetillo G, Osman A, Ahmed Y, Elmi H, Nur O, Iteghete S, Torres-Herbeck G, Dirie H, Clark M, Lohr A, Smith K, Zeratsky K, Rieck T, Herrin J, Valente T, Sia I. Healthy immigrant community study protocol: A randomized controlled trial of a social network intervention for cardiovascular risk reduction among Hispanic and Somali adults. Contemporary Clinical Trials 2024, 138: 107465. PMID: 38309526, PMCID: PMC10923143, DOI: 10.1016/j.cct.2024.107465.Peer-Reviewed Original ResearchConceptsLife's Simple 7Social network interventionsHealth promotionCardiovascular risk factorsCardiovascular risk reductionAmerican Heart Association's Life's Simple 7Health promotion interventionsPhysical activity levelsNetwork interventionsStepped wedge cluster randomized designReducing cardiovascular risk factorsCluster randomized trialStepped wedge cluster randomized trialNegative health behaviorsCluster randomized designRisk factorsHealthy weight lossRisk reductionRandomized controlled trialsImmigrant populationPromotion interventionsSomali adultsHealth behaviorsSomali immigrant communityWaist circumference
2020
Fewer gastrointestinal bleeds with ticagrelor and prasugrel compared with clopidogrel in patients with acute coronary syndrome following percutaneous coronary intervention
Abraham NS, Yang EH, Noseworthy PA, Inselman J, Yao X, Herrin J, Sangaralingham LR, Ngufor C, Shah ND. Fewer gastrointestinal bleeds with ticagrelor and prasugrel compared with clopidogrel in patients with acute coronary syndrome following percutaneous coronary intervention. Alimentary Pharmacology & Therapeutics 2020, 52: 646-654. PMID: 32657466, PMCID: PMC8183594, DOI: 10.1111/apt.15790.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedClopidogrelCohort StudiesFemaleGastrointestinal HemorrhageHumansMaleMiddle AgedPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPostoperative ComplicationsPrasugrel HydrochlorideRetrospective StudiesThromboembolismTicagrelorTreatment OutcomeUnited StatesConceptsPercutaneous coronary interventionAcute coronary syndromeGIB ratesGIB riskCoronary syndromeGastrointestinal bleedingSTEMI patientsCoronary interventionHazard ratioMajor adverse cardiac eventsRisk reductionCox proportional hazards modelNSTE-ACS patientsAdverse cardiac eventsMajor bleeding eventsConfidence intervalsInverse probability treatmentProportional hazards modelMedicare Advantage enrolleesBleeding eventsClopidogrel prescriptionGIB eventsNSTE-ACSGastrointestinal bleedBaseline characteristics
2011
Using alternative statistical formats for presenting risks and risk reductions
Akl EA, Oxman AD, Herrin J, Vist GE, Terrenato I, Sperati F, Costiniuk C, Blank D, Schünemann H. Using alternative statistical formats for presenting risks and risk reductions. Cochrane Database Of Systematic Reviews 2011, 2011: cd006776. PMID: 21412897, PMCID: PMC6464912, DOI: 10.1002/14651858.cd006776.pub2.Peer-Reviewed Original ResearchConceptsPolicy makersAbsolute risk reductionRelative risk reductionStatistical presentationStandardized mean differenceHigh quality comparisonsRisk reductionHealth professionalsMakersSensitivity analysisConsumersCochrane Central RegisterCross-over studyQuality of evidenceRisk of biasStatistical informationCentral RegisterGRADE approachControlled TrialsDATA COLLECTIONEvidence-based practiceSurrogate outcomesOvid MEDLINEOutcome effectsReference lists
2010
The Effect of How Outcomes Are Framed on Decisions about Whether to Take Antihypertensive Medication: A Randomized Trial
Carling CL, Kristoffersen DT, Oxman AD, Flottorp S, Fretheim A, Schünemann HJ, Akl EA, Herrin J, MacKenzie TD, Montori VM. The Effect of How Outcomes Are Framed on Decisions about Whether to Take Antihypertensive Medication: A Randomized Trial. PLOS ONE 2010, 5: e9469. PMID: 20209127, PMCID: PMC2830888, DOI: 10.1371/journal.pone.0009469.Peer-Reviewed Original ResearchConceptsAntihypertensive medicationsVisual analog scaleCardiovascular diseaseVAS scoresRelative importance scoresCVD risk reductionYear old manLow baseline riskDetailed patient informationRandomized trialsAnalog scaleRisk factorsBaseline riskMedicationsAdult volunteersHypertensionLogistic regressionPatient informationSignificant decreaseTrialsSignificant differencesRisk reductionPresentationParticipantsRisk