2024
Primary outcomes of the enhanced, EHR-facilitated cancer symptom control (E2C2) cluster-randomized, stepped wedge, pragmatic trial.
Cheville A, Pachman D, Kroenke K, Herrin J, Grzegorczyk V, Mitchell S, Griffin J, Ridgeway J, Austin J, Smith A, Chlan L, Tofthagen C, Ruddy K. Primary outcomes of the enhanced, EHR-facilitated cancer symptom control (E2C2) cluster-randomized, stepped wedge, pragmatic trial. Journal Of Clinical Oncology 2024, 42: lba12006-lba12006. DOI: 10.1200/jco.2024.42.17_suppl.lba12006.Peer-Reviewed Original ResearchElectronic patient-reported outcome measuresCollaborative care modelElectronic health recordsNumerical rating scaleCluster-randomizedPragmatic trialSymptom burdenAssociated with adverse health outcomesCCM-based interventionsPatient-reported outcome measuresHealth service outcomesSelf-management informationClinician decision supportPrimary outcomeCancer type or stageMulti-state health systemCancer symptom controlCluster randomized trialMedical oncology clinicAdverse health outcomesUsual careCare modelCare teamSymptom managementSymptom scoresMultilevel Implementation Strategies for Adolescent Human Papillomavirus Vaccine Uptake
Rutten L, Griffin J, St. Sauver J, MacLaughlin K, Austin J, Jenkins G, Herrin J, Jacobson R. Multilevel Implementation Strategies for Adolescent Human Papillomavirus Vaccine Uptake. JAMA Pediatrics 2024, 178: 29-36. PMID: 37983062, PMCID: PMC10957109, DOI: 10.1001/jamapediatrics.2023.4932.Peer-Reviewed Original ResearchConceptsAudit/feedbackReminder/recallHPV vaccine uptakeUsual careHPV vaccinationHPV vaccineVaccine uptakeHuman papillomavirusNational public health goalsHuman papillomavirus vaccine uptakeMultilevel implementation strategyHPV vaccination ratesPrimary care practicesHealth care professionalsEvidence-based interventionsPublic health goalsEvidence-based strategiesAdolescent vaccinesEligible patientsNew cancersPatient receiptVaccination ratesEligible childrenClinical trialsMayo Clinic
2019
What is the effect of a decision aid in potentially vulnerable parents? Insights from the head CT choice randomized trial
Skains RM, Kuppermann N, Homme JL, Kharbanda AB, Tzimenatos L, Louie JP, Cohen DM, Nigrovic LE, Westphal JJ, Shah ND, Inselman J, Ferrara MJ, Herrin J, Montori VM, Hess EP. What is the effect of a decision aid in potentially vulnerable parents? Insights from the head CT choice randomized trial. Health Expectations 2019, 23: 63-74. PMID: 31758633, PMCID: PMC6978876, DOI: 10.1111/hex.12965.Peer-Reviewed Original ResearchConceptsLow health literacyPhysician trustNon-white parentsHealth literacyDecisional conflictImportant traumatic brain injuryTraumatic brain injuryDecision aidLess decisional conflictDisadvantaged parentsGreater increaseUsual careIntermediate riskVulnerable parentsBrain injuryHigher numeracySecondary analysisSubgroup effectsArm assignmentPatient dyadsSocioeconomic statusTrialsRegression modelsParent characteristicsParents
2018
Effect of the Head Computed Tomography Choice Decision Aid in Parents of Children With Minor Head Trauma
Hess EP, Homme JL, Kharbanda AB, Tzimenatos L, Louie JP, Cohen DM, Nigrovic LE, Westphal JJ, Shah ND, Inselman J, Ferrara MJ, Herrin J, Montori VM, Kuppermann N. Effect of the Head Computed Tomography Choice Decision Aid in Parents of Children With Minor Head Trauma. JAMA Network Open 2018, 1: e182430. PMID: 30646167, PMCID: PMC6324506, DOI: 10.1001/jamanetworkopen.2018.2430.Peer-Reviewed Original ResearchConceptsMinor head traumaIntermediate riskHead traumaParents of childrenComputed tomographyDecisional conflictUsual careEmergency departmentImportant traumatic brain injuryCT ratesDecision aid armPatients' mean ageUsual care armUS emergency departmentsHealth care utilizationAvailable diagnostic optionsTraumatic brain injuryDecision aidChildren ages 2Care armSecondary outcomesPrimary outcomeCare utilizationNonwhite raceEligible participants
2017
Impact of Telemonitoring on Health Status
Jayaram NM, Khariton Y, Krumholz HM, Chaudhry SI, Mattera J, Tang F, Herrin J, Hodshon B, Spertus JA. Impact of Telemonitoring on Health Status. Circulation Cardiovascular Quality And Outcomes 2017, 10: e004148. PMID: 29237746, PMCID: PMC5776725, DOI: 10.1161/circoutcomes.117.004148.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy QuestionnaireUsual careHealth statusHeart failureKCCQ overall summary scoreRecent heart failure hospitalizationDisease-specific health statusKCCQ overall summaryHeart failure hospitalizationWeeks of dischargeRandomized clinical trialsOverall summary scoreKCCQ scoresNoninvasive TelemonitoringFailure hospitalizationBaseline characteristicsSecondary outcomesTreatment armsClinical trialsSummary scoresPatientsSubscale scoresCareHospitalizationScoresEffectiveness of a Decision Aid in Potentially Vulnerable Patients: A Secondary Analysis of the Chest Pain Choice Multicenter Randomized Trial
Rising K, Hollander J, Schaffer J, Kline J, Torres C, Diercks D, Jones R, Owen K, Meisel Z, Demers M, Leblanc A, Shah N, Inselman J, Herrin J, Montori V, Hess E. Effectiveness of a Decision Aid in Potentially Vulnerable Patients: A Secondary Analysis of the Chest Pain Choice Multicenter Randomized Trial. Medical Decision Making 2017, 38: 69-78. PMID: 28525723, DOI: 10.1177/0272989x17706363.Peer-Reviewed Original ResearchConceptsUsual careHealth literacySecondary analysisAcute coronary syndromeDecision aidOne-thirdChest painCoronary syndromePatient characteristicsSDM interventionsIntervention groupVulnerable patientsHigh school educationPatientsControl groupPhysician trustPatient trustSubgroup effectsArm assignmentVulnerable subgroupsSociodemographic groupsMulticenterTrialsSimilar extentPhysicians
2016
Shared decision making in patients with low risk chest pain: prospective randomized pragmatic trial
Hess EP, Hollander JE, Schaffer JT, Kline JA, Torres CA, Diercks DB, Jones R, Owen KP, Meisel ZF, Demers M, Leblanc A, Shah ND, Inselman J, Herrin J, Castaneda-Guarderas A, Montori VM. Shared decision making in patients with low risk chest pain: prospective randomized pragmatic trial. The BMJ 2016, 355: i6165. PMID: 27919865, PMCID: PMC5152707, DOI: 10.1136/bmj.i6165.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAdultAftercareAmbulatory CareAttitude of Health PersonnelChest PainChoice BehaviorConflict, PsychologicalDecision MakingDecision Support TechniquesEmergency Service, HospitalFemaleHealth Knowledge, Attitudes, PracticeHospital UnitsHospitalizationHumansMaleMiddle AgedMyocardial InfarctionObservationPatient Acceptance of Health CarePatient ParticipationPatient SatisfactionRisk AssessmentTrustConceptsAcute coronary syndromeMajor adverse cardiac eventsAdverse cardiac eventsCardiac testingCoronary syndromeChest painUsual careCardiac eventsPatient knowledgeLow-risk chest painPossible acute coronary syndromeDecision aid armFurther cardiac testingRandomized pragmatic trialRisk chest painUsual care armObservation unitProportion of patientsRate of admissionCare armSecondary outcomesPrimary outcomePrimary complaintTRIAL REGISTRATIONEmergency clinicians
2015
Shared Decision Making for Antidepressants in Primary Care: A Cluster Randomized Trial
LeBlanc A, Herrin J, Williams MD, Inselman JW, Branda ME, Shah ND, Heim EM, Dick SR, Linzer M, Boehm DH, Dall-Winther KM, Matthews MR, Yost KJ, Shepel KK, Montori VM. Shared Decision Making for Antidepressants in Primary Care: A Cluster Randomized Trial. JAMA Internal Medicine 2015, 175: 1761-1770. PMID: 26414670, PMCID: PMC4754973, DOI: 10.1001/jamainternmed.2015.5214.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntidepressive AgentsChoice BehaviorCluster AnalysisComparative Effectiveness ResearchDecision MakingDecision Support TechniquesDepressionFemaleHumansMaleMedication AdherenceMiddle AgedMinnesotaOutcome Assessment, Health CarePatient ParticipationPractice Patterns, Physicians'Primary Health CarePsychiatric Status Rating ScalesWisconsinConceptsPrimary care practicesDecisional comfortMedication adherenceUsual careDepression outcomesPrimary careSevere depressionCare practicesComparative effectivenessUrban primary care practicesEncounter decision aidsTrials of adultsPrimary care cliniciansPatient Health QuestionnaireTreatment of depressionPatient-centered careQuality of careTranslation of evidenceCluster Randomized TrialDecision aidEffects of DMCUse of DMCAvailable antidepressantsCare cliniciansMedication choice
2014
Effectiveness of the head CT choice decision aid in parents of children with minor head trauma: study protocol for a multicenter randomized trial
Hess EP, Wyatt KD, Kharbanda AB, Louie JP, Dayan PS, Tzimenatos L, Wootton-Gorges SL, Homme JL, RN L, LeBlanc A, Westphal JJ, Shepel K, Shah ND, Branda M, Herrin J, Montori VM, Kuppermann N. Effectiveness of the head CT choice decision aid in parents of children with minor head trauma: study protocol for a multicenter randomized trial. Trials 2014, 15: 253. PMID: 24965659, PMCID: PMC4081461, DOI: 10.1186/1745-6215-15-253.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryDiverse emergency departmentsMinor head traumaCranial CT scanHead traumaEmergency departmentCT scanUsual careHealthcare utilizationParents of childrenImportant traumatic brain injuryMethods/designThisProportion of patientsBlunt head traumaHospital billing recordsPatient-centered outcomesClinical prediction ruleAvailable diagnostic optionsHead CT scanDecision aidElectronic medical recordsClinician surveyMulticenter trialMedical recordsRisk factorsEffectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial
Anderson RT, Montori VM, Shah ND, Ting HH, Pencille LJ, Demers M, Kline JA, Diercks DB, Hollander JE, Torres CA, Schaffer JT, Herrin J, Branda M, Leblanc A, Hess EP. Effectiveness of the Chest Pain Choice decision aid in emergency department patients with low-risk chest pain: study protocol for a multicenter randomized trial. Trials 2014, 15: 166. PMID: 24884807, PMCID: PMC4031497, DOI: 10.1186/1745-6215-15-166.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAngina, UnstableCardiology Service, HospitalClinical ProtocolsCommunicationConflict, PsychologicalDecision Support TechniquesEmergency Service, HospitalHealth Knowledge, Attitudes, PracticeHealth ResourcesHumansMyocardial InfarctionPatient Education as TopicPhysician-Patient RelationsPredictive Value of TestsPrognosisResearch DesignRisk AssessmentRisk FactorsSurveys and QuestionnairesTime FactorsUnited StatesVideo RecordingConceptsAdvanced cardiac testingAcute coronary syndromeDiverse emergency departmentsEmergency departmentCardiac testingHealthcare utilizationLow-risk chest pain patientsLow-risk chest painMajor adverse cardiac eventsMethods/designThisAdverse cardiac eventsLow-risk patientsProportion of patientsChest pain patientsCommon reason patientsEmergency department patientsPatient-clinician discussionsHospital billing recordsPatient-centered outcomesElectronic medical recordsAvailable management optionsDecision aidChest painCoronary syndromeUsual care
2013
Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial
LeBlanc A, Bodde AE, Branda ME, Yost KJ, Herrin J, Williams MD, Shah ND, Houten HV, Ruud KL, Pencille LJ, Montori VM. Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial. Trials 2013, 14: 127. PMID: 23782672, PMCID: PMC3663744, DOI: 10.1186/1745-6215-14-127.Peer-Reviewed Original ResearchMeSH KeywordsAntidepressive AgentsClinical ProtocolsComparative Effectiveness ResearchDecision Support TechniquesDepressionHumansMedication AdherenceMental HealthMidwestern United StatesPatient SelectionPatient-Centered CarePrimary Health CareResearch DesignSurveys and QuestionnairesTime FactorsTreatment OutcomeConceptsUsual depression carePrimary care practicesDepression careInner-city primary care practiceCare practicesPractice-based trialPrimary care encountersTerms of efficacyDecision aidPatient-centered approachDesignThe objectiveAntidepressant therapyUsual careMedication choiceDepression medicationsDepression treatmentMedication adherencePatient knowledgeStudy protocolSevere depressionCare encountersImproved adherencePatient representativesPatient involvementPatients
2010
Telemonitoring in Patients with Heart Failure
Chaudhry SI, Mattera JA, Curtis JP, Spertus JA, Herrin J, Lin Z, Phillips CO, Hodshon BV, Cooper LS, Krumholz HM. Telemonitoring in Patients with Heart Failure. New England Journal Of Medicine 2010, 363: 2301-2309. PMID: 21080835, PMCID: PMC3237394, DOI: 10.1056/nejmoa1010029.Peer-Reviewed Original ResearchConceptsPrimary end pointUsual care groupSecondary end pointsHeart failureEnd pointHeart failure outcomesNumber of hospitalizationsTelephone-based interactive voice response systemUsual careAdverse eventsPatient's clinicianMedian ageCare groupLarge trialsInteractive voice response systemPatientsSmall studyVoice response systemNumber of daysHospitalizationReadmissionTelemonitoringSignificant differencesCliniciansDeath
2005
A Randomized Outpatient Trial of a Decision-Support Information Technology Tool
Apkon M, Mattera JA, Lin Z, Herrin J, Bradley EH, Carbone M, Holmboe ES, Gross CP, Selter JG, Rich AS, Krumholz HM. A Randomized Outpatient Trial of a Decision-Support Information Technology Tool. JAMA Internal Medicine 2005, 165: 2388-2394. PMID: 16287768, DOI: 10.1001/archinte.165.20.2388.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmbulatory CareAttitude of Health PersonnelCost-Benefit AnalysisDecision Support Systems, ClinicalFemaleFloridaHealth ResourcesHospitals, MilitaryHumansKentuckyMaleMass ScreeningMultivariate AnalysisOutcome and Process Assessment, Health CarePatient SatisfactionPreventive MedicineQuality of Health CareConceptsProvider satisfactionAmbulatory clinic visitsUsual care patientsDays of enrollmentQuality process measuresQuality of careProportion of opportunitiesUsual careClinic visitsOutpatient trialSecondary outcomesPrimary outcomeAcute carePatient satisfactionIntervention groupHealth care opportunitiesPatientsClinical decisionCare opportunitiesPharmacy resourcesPreventive measuresProcess measuresCareMedical resourcesModest improvement