The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells.
Jung C, Motwani M, Kortmansky J, Sirotnak FM, She Y, Gonen M, Haimovitz-Friedman A, Schwartz GK. The cyclin-dependent kinase inhibitor flavopiridol potentiates gamma-irradiation-induced apoptosis in colon and gastric cancer cells. Clinical Cancer Research 2003, 9: 6052-61. PMID: 14676132.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsApoptosisCaspase 3CaspasesCell DivisionColonic NeoplasmsCyclin-Dependent Kinase Inhibitor p21Cyclin-Dependent KinasesCyclinsCytochromes cEnzyme ActivationEnzyme InhibitorsFlavonoidsGamma RaysMaleMiceMice, NudeMicroscopy, FluorescencePiperidinesPoly(ADP-ribose) PolymerasesStomach NeoplasmsTransplantation, HeterologousTumor Cells, CulturedConceptsEffect of flavopiridolHCT-116 cellsMKN-74Single agentInduction of apoptosisParental HCT-116 cellsAdvanced gastrointestinal cancerTumor-bearing animalsCyclin-dependent kinase inhibitor flavopiridolEfficacy of combinationNational Cancer InstituteMKN-74 cellsGastric cancer cellsP21 protein expressionKinase inhibitor flavopiridolAdjuvant treatmentCyclin-dependent kinase inhibitorLoss of p21HCT-116Gastrointestinal cancerTumor regressionCancer cell line HCT-116Human colon cancer cell line HCT-116Gastric cancerCancer Institute