2023
System‐wide optimization of an orthogonal translation system with enhanced biological tolerance
Mohler K, Moen J, Rogulina S, Rinehart J. System‐wide optimization of an orthogonal translation system with enhanced biological tolerance. Molecular Systems Biology 2023, 19: msb202110591. PMID: 37477096, PMCID: PMC10407733, DOI: 10.15252/msb.202110591.Peer-Reviewed Original ResearchConceptsOrthogonal translation systemHost interactionsNon-standard amino acidsPost-translational modificationsSystems-level biologyStress response activationTranslation systemSynthetic biological systemsCellular physiologyProtein phosphorylationOTS performanceHost physiologyCellular environmentAmino acidsCellular mechanismsDeleterious interactionsResponse activationBiological systemsPhysiologyOTS developmentUnparalleled accessPhosphorylationHost toxicityBiologyInteraction
2017
Encoding the Human Phosphoproteome in an Engineered Bacterial System
Barber K, Rinehart J. Encoding the Human Phosphoproteome in an Engineered Bacterial System. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.614.33.Peer-Reviewed Original Research
2015
Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids
Amiram M, Haimovich AD, Fan C, Wang YS, Aerni HR, Ntai I, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Söll D, Rinehart J, Isaacs FJ. Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids. Nature Biotechnology 2015, 33: 1272-1279. PMID: 26571098, PMCID: PMC4784704, DOI: 10.1038/nbt.3372.Peer-Reviewed Original Research