Featured Publications
Genomically Recoded Organisms Expand Biological Functions
Lajoie MJ, Rovner AJ, Goodman DB, Aerni HR, Haimovich AD, Kuznetsov G, Mercer JA, Wang HH, Carr PA, Mosberg JA, Rohland N, Schultz PG, Jacobson JM, Rinehart J, Church GM, Isaacs FJ. Genomically Recoded Organisms Expand Biological Functions. Science 2013, 342: 357-360. PMID: 24136966, PMCID: PMC4924538, DOI: 10.1126/science.1241459.Peer-Reviewed Original ResearchConceptsNew genetic codesRelease factor 1UAG stop codonNonstandard amino acidsEscherichia coli MG1655UAA codonGenetic codeColi MG1655Biological functionsStop codonChemical diversityT7 bacteriophageAmino acidsFactor 1CodonMG1655OrganismsProteinDiversityDeletionBacteriophagesViral resistanceTranslation functionGROVivo
2015
Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids
Amiram M, Haimovich AD, Fan C, Wang YS, Aerni HR, Ntai I, Moonan DW, Ma NJ, Rovner AJ, Hong SH, Kelleher NL, Goodman AL, Jewett MC, Söll D, Rinehart J, Isaacs FJ. Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids. Nature Biotechnology 2015, 33: 1272-1279. PMID: 26571098, PMCID: PMC4784704, DOI: 10.1038/nbt.3372.Peer-Reviewed Original Research