Src‐family protein tyrosine kinase (SFK) stimulates KCNJ10 K channels in the basolateral membrane of distal convoluted tubules (DCT).
Wang W, Zhang C, Lin D, Yue P, Wang L, Rinehart J. Src‐family protein tyrosine kinase (SFK) stimulates KCNJ10 K channels in the basolateral membrane of distal convoluted tubules (DCT). The FASEB Journal 2013, 27: 911.1-911.1. DOI: 10.1096/fasebj.27.1_supplement.911.1.Peer-Reviewed Original ResearchSrc family protein tyrosine kinasesPhosphorylation sitesWhole-cell K currentsTyrosine phosphorylationTyr-8Tyr-9Tyrosine phosphorylation sitesProtein tyrosine kinasesTyrosine phosphorylated proteinsBasolateral K channelsPhosphorylated proteinsBasolateral Cl(-) exitSFK activityHigh K dietTyrosine kinaseK channelsPhysiological roleHEK293 cellsCl exitHEK cellsDCT1Patch-clamp experimentsBasolateral membraneKCNJ10PhosphorylationSrc‐family tyrosine kinase (SFK) phosphorylates With‐No‐ Lysine Kinase4 (WNK4) and modulates the inhibitory effect of WNK4 on ROMK channels.
Lin D, Yue P, Yarborough O, Lifton R, Rinehart J, Wang W. Src‐family tyrosine kinase (SFK) phosphorylates With‐No‐ Lysine Kinase4 (WNK4) and modulates the inhibitory effect of WNK4 on ROMK channels. The FASEB Journal 2013, 27: 911.2-911.2. DOI: 10.1096/fasebj.27.1_supplement.911.2.Peer-Reviewed Original Research