2018
Thrombin-Responsive, Brain-Targeting Nanoparticles for Improved Stroke Therapy
Guo X, Deng G, Liu J, Zou P, Du F, Liu F, Chen AT, Hu R, Li M, Zhang S, Tang Z, Han L, Liu J, Sheth KN, Chen Q, Gou X, Zhou J. Thrombin-Responsive, Brain-Targeting Nanoparticles for Improved Stroke Therapy. ACS Nano 2018, 12: 8723-8732. PMID: 30107729, DOI: 10.1021/acsnano.8b04787.Peer-Reviewed Original ResearchConceptsBrain-targeted nanoparticlesIschemic brainEfficacy of glyburideImproved treatmentIschemic brain tissueEffective pharmacological approachBlood-brain barrierMatrix metalloproteinase-9Ischemic strokeStroke patientsStroke therapyMetalloproteinase-9Current treatmentPharmacological approachesBrain tissueIschemic microenvironmentTherapeutic drugsGreater delivery efficiencyBrainClinical applicationStrokeTreatmentTargeted deliveryEfficacyVariety of formulations
2011
Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery
Zhou J, Liu J, Cheng CJ, Patel TR, Weller CE, Piepmeier JM, Jiang Z, Saltzman WM. Biodegradable poly(amine-co-ester) terpolymers for targeted gene delivery. Nature Materials 2011, 11: 82-90. PMID: 22138789, PMCID: PMC4180913, DOI: 10.1038/nmat3187.Peer-Reviewed Original ResearchConceptsGene deliveryNon-viral gene deliveryEfficient gene deliveryGene delivery abilityTargeted gene deliveryHighest molecular weight terpolymerDelivery abilityTargeted deliveryLipofectamine 2000Dialkyl diesterVivo applicationsPolycationic vectorsSpecific ring sizesTRAIL geneHigh efficiencyCharge densityLow charge densityDeliveryPolyethylenimineMinimal toxicityEfficiencyHydrophobicityLactone contentDensityApplications