Inducing mitophagy in diabetic platelets protects against severe oxidative stress
Lee SH, Du J, Stitham J, Atteya G, Lee S, Xiang Y, Wang D, Jin Y, Leslie KL, Spollett G, Srivastava A, Mannam P, Ostriker A, Martin KA, Tang WH, Hwa J. Inducing mitophagy in diabetic platelets protects against severe oxidative stress. EMBO Molecular Medicine 2016, 8: 779-795. PMID: 27221050, PMCID: PMC4931291, DOI: 10.15252/emmm.201506046.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisBlood PlateletsDiabetes MellitusHumansMAP Kinase Signaling SystemMitophagyOxidative StressPhosphorylationProtein Processing, Post-TranslationalTumor Suppressor Protein p53ConceptsDiabetes mellitusOxidative stressThrombotic cardiovascular eventsAnticipation of exposureCardiovascular eventsOxidative stress-mediated mitochondrial damageNormal platelet activationDiabetic plateletsPlatelet functionPlatelet pathologyPlatelet activationSevere oxidative stressNormal plateletsConsiderable mortalityProtective mechanismMitochondrial damageMellitusThrombosisPlateletsMitophagy inductionPhosphorylated p53Mitophagy machineryPlatelets resultsAutophagy processJNK activation