1994
The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes.
Toczyski DP, Matera AG, Ward DC, Steitz JA. The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 3463-3467. PMID: 8159770, PMCID: PMC43597, DOI: 10.1073/pnas.91.8.3463.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusHuman B lymphocytesB lymphocytesEBV-positive lymphocytesEBV-positive cellsEBER1 RNAUninfected human cellsCertain patientsEBER1Ribosomal protein L22LymphocytesChromosomal translocationsOncogenic herpesvirusProtein L22Situ hybridizationUninfected cell extractsNucleoplasmic stainingVivoCell transformationHigh levelsHuman cellsCellsPatientsLeukemiaCellular proteins
1986
Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders.
Mimori T, Hardin JA, Steitz JA. Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. Journal Of Biological Chemistry 1986, 261: 2274-2278. PMID: 3511059, DOI: 10.1016/s0021-9258(17)35929-x.Peer-Reviewed Original ResearchConceptsKu proteinNovel DNA-binding proteinAnti-Ku antibodiesDNA-binding proteinsHigh molecular weight nucleic acidsExtracts of cellsKu antigenDa subunitChromatinHeLa cellsScleroderma-polymyositis overlap syndromeBiochemical natureProteinWeight nucleic acidsLarge formNucleic acidsOverlap syndromeRheumatic disordersCertain patientsAntibodiesAntigenAutoantibodiesCellsImmunoaffinity column chromatographyPatients
1982
Antibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles.
Hardin JA, Rahn DR, Shen C, Lerner MR, Wolin SL, Rosa MD, Steitz JA. Antibodies from patients with connective tissue diseases bind specific subsets of cellular RNA-protein particles. Journal Of Clinical Investigation 1982, 70: 141-147. PMID: 6806318, PMCID: PMC370236, DOI: 10.1172/jci110587.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusLupus erythematosusRheumatoid arthritisPatient seraHepatitis B virus infectionB virus infectionPositive antinuclear antibodyRheumatic disease patientsJuvenile rheumatoid arthritisConnective tissue diseaseAntinuclear antibodiesSjögren's syndromeTissue diseaseDisease patientsAntigenic interrelationshipsSpecific subsetVirus infectionPatientsSuch seraMonoclonal immunoglobulin GImmunoglobulin GSerumAntibodiesAntigenic determinantsErythematosus
1981
Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.
Lerner EA, Lerner MR, Janeway CA, Steitz JA. Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease. Proceedings Of The National Academy Of Sciences Of The United States Of America 1981, 78: 2737-2741. PMID: 6789322, PMCID: PMC319432, DOI: 10.1073/pnas.78.5.2737.Peer-Reviewed Original ResearchConceptsAnti-Sm antibodiesMonoclonal anti-Sm antibodyAutoimmune diseasesMonoclonal antibodiesLupus erythematosus-like syndromeMRL/Mp-lpr/lprProduction of autoantibodiesPatient seraSpleen cellsImmunofluorescence techniqueAntibodiesSP 2/0Competition radioimmunoassayImmunoprecipitation patternsCell linesSm antigenAntigenDiseaseMiceCellular constituentsCellular componentsAutoantibodiesPatientsLupusSyndrome