Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps.
Tarn WY, Steitz JA. Modulation of 5' splice site choice in pre-messenger RNA by two distinct steps. Proceedings Of The National Academy Of Sciences Of The United States Of America 1995, 92: 2504-2508. PMID: 7708674, PMCID: PMC42246, DOI: 10.1073/pnas.92.7.2504.Peer-Reviewed Original ResearchConceptsSmall nuclear ribonucleoproteinU1 small nuclear ribonucleoproteinSplice site choicePre-messenger RNASR proteinsSplice site selectionSplice siteSite choiceSer/Arg-rich (SR) proteinsU2 small nuclear ribonucleoproteinU1 snRNP functionsHeLa cell nuclear extractsEssential splicing factorArg-rich proteinsCell nuclear extractsDistinct stepsSnRNP functionSite selectionSplicing factorsU1 bindingNuclear ribonucleoproteinU1 RNANuclear extractsProteinRNA