1985
Association of the lupus antigen La with a subset of U6 snRNA molecules
Rinke J, Steitz J. Association of the lupus antigen La with a subset of U6 snRNA molecules. Nucleic Acids Research 1985, 13: 2617-2629. PMID: 2582364, PMCID: PMC341179, DOI: 10.1093/nar/13.7.2617.Peer-Reviewed Original Research
1983
Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein
Padgett R, Mount S, Steitz J, Sharp P. Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein. Cell 1983, 35: 101-107. PMID: 6194895, DOI: 10.1016/0092-8674(83)90212-x.Peer-Reviewed Original ResearchGenes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome
Wolin S, Steitz J. Genes for two small cytoplasmic Ro RNAs are adjacent and appear to be single-copy in the human genome. Cell 1983, 32: 735-744. PMID: 6187471, DOI: 10.1016/0092-8674(83)90059-4.Peer-Reviewed Original ResearchConceptsHuman genomeRo RNAsSecondary structure homologyRNA polymerase IIISmall cytoplasmic ribonucleoproteinsClass III genesGenomic clonesMammalian cellsPolymerase IIIRNA componentStructure homologySingle copyCytoplasmic ribonucleoproteinHY5 RNAMouse cellsHuman cellsHY1Cell extractsGenesRNAGenomeRNAsHY3CellsMY1A mammalian tRNA His-Containing antigen is recognized by the polymyosits-specific antibody antijo-1
Rosa M, Hendrick J, Lerner M, Steitz J, Reichlin M. A mammalian tRNA His-Containing antigen is recognized by the polymyosits-specific antibody antijo-1. Nucleic Acids Research 1983, 11: 853-870. PMID: 6188108, PMCID: PMC325757, DOI: 10.1093/nar/11.3.853.Peer-Reviewed Original ResearchConceptsMammalian cell cytoplasmWobble positionMammalian tRNAHuman HeLaProteinase K treatmentRNA sequencesBase queuineTerminal nucleotidesCell extractsTRNACell cytoplasmAntigenic proteinsImmunofluorescence studiesPhenol extractionK treatmentSephacryl SMethylated guaninesAntigenic formsTRNAHisAntigenic complexQueuineAnticodonUnusual featuresColumn chromatographyNucleotidesSequential association of nucleolar 7-2 RNA with two different autoantigens.
Hashimoto C, Steitz JA. Sequential association of nucleolar 7-2 RNA with two different autoantigens. Journal Of Biological Chemistry 1983, 258: 1379-1382. PMID: 6185483, DOI: 10.1016/s0021-9258(18)32990-9.Peer-Reviewed Original Research
1982
New directions in antinuclear antibody research: the Sm, RNP, Ro, and La antigens are found on small-RNA protein particles.
Hardin JA, Lerner MR, Lerner EA, Steitz JA. New directions in antinuclear antibody research: the Sm, RNP, Ro, and La antigens are found on small-RNA protein particles. American Journal Of Kidney Diseases 1982, 2: 98-100. PMID: 6179414.Peer-Reviewed Original ResearchDeciphering the mysteries of RNA‐containing lupus antigens
Lerner E, Lerner M, Hardin J, Janeway C, Steitz J. Deciphering the mysteries of RNA‐containing lupus antigens. Arthritis & Rheumatism 1982, 25: 761-766. PMID: 6179522, DOI: 10.1002/art.1780250709.Peer-Reviewed Original ResearchPrecursor molecules of both human 5S ribosomal RNA and transfer RNAs are bound by a cellular protein reactive with anti-La Lupus antibodies
Rinke J, Steitz J. Precursor molecules of both human 5S ribosomal RNA and transfer RNAs are bound by a cellular protein reactive with anti-La Lupus antibodies. Cell 1982, 29: 149-159. PMID: 7105180, DOI: 10.1016/0092-8674(82)90099-x.Peer-Reviewed Original ResearchConceptsRRNA moleculesLa proteinLa RNAsPrecursor formNuclear transcription systemUninfected mammalian cellsPulse-chase experimentsSmall RNAsSmall ribonucleoproteinPrecursor moleculesTransfer RNAMammalian cellsRibosomal RNATRNA precursorsCertain tRNAsSpecific tRNAsRNA transcriptsTranscription systemU residuesCell extractsMature sizeHeLa cellsRNAEssential roleProtein
1981
Two Novel Classes of Small Ribonucleoproteins Detected by Antibodies Associated with Lupus Erythematosus
Lerner M, Boyle J, Hardin J, Steitz J. Two Novel Classes of Small Ribonucleoproteins Detected by Antibodies Associated with Lupus Erythematosus. Science 1981, 211: 400-402. PMID: 6164096, DOI: 10.1126/science.6164096.Peer-Reviewed Original Research