2015
Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis
Nevius E, Pinho F, Dhodapkar M, Jin H, Nadrah K, Horowitz MC, Kikuta J, Ishii M, Pereira JP. Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. Journal Of Experimental Medicine 2015, 212: 1931-1946. PMID: 26438360, PMCID: PMC4612084, DOI: 10.1084/jem.20150088.Peer-Reviewed Original ResearchConceptsOC precursorsBone surfaceEstrogen deficiency-induced osteoporosisBone mass homeostasisCell-cell interactionsTime-lapse microscopyBone metastatic cancerSignificant therapeutic potentialOxysterol ligandsFemale miceMale miceBone massMetastatic cancerLarge osteoclastsEBI2Nonhematopoietic cellsNovel pathwayTherapeutic potentialOsteoclastsTwo-photon microscopyMiceOsteoblastsVivoCellsOsteoporosis
2011
EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues
Kelly LM, Pereira JP, Yi T, Xu Y, Cyster JG. EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues. The Journal Of Immunology 2011, 187: 3026-3032. PMID: 21844396, PMCID: PMC3169736, DOI: 10.4049/jimmunol.1101262.Peer-Reviewed Original ResearchConceptsActivated B cellsB cellsAb responsesNonlymphoid tissuesCCR7-dependent mannerSecondary lymphoid organsDependent Ab responsesB cell migrationLigand activityCCR7 downregulationLymphoid organsFollicular regionsEBI2Outer follicleT zoneCD40 engagementCell linesLipid ligandsLymphoidCell migrationGene 2CellsTissueSerial movementsEarly waveOxysterols direct immune cell migration via EBI2
Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, Noël S, Gessier F, Kelly LM, Vanek M, Laurent S, Preuss I, Miault C, Christen I, Karuna R, Li W, Koo DI, Suply T, Schmedt C, Peters EC, Falchetto R, Katopodis A, Spanka C, Roy MO, Detheux M, Chen YA, Schultz PG, Cho CY, Seuwen K, Cyster JG, Sailer AW. Oxysterols direct immune cell migration via EBI2. Nature 2011, 475: 524-527. PMID: 21796212, PMCID: PMC4297623, DOI: 10.1038/nature10280.Peer-Reviewed Original Research
2009
EBI2 mediates B cell segregation between the outer and centre follicle
Pereira JP, Kelly LM, Xu Y, Cyster JG. EBI2 mediates B cell segregation between the outer and centre follicle. Nature 2009, 460: 1122-1126. PMID: 19597478, PMCID: PMC2809436, DOI: 10.1038/nature08226.Peer-Reviewed Original ResearchConceptsB cellsAntibody responseEpstein-Barr virus infectionOrphan G protein-coupled receptorOuter follicleB cell segregationNormal B cell proliferationDefective antibody responsesB cell positioningGerminal center B cellsActivated B cellsB cell proliferationG protein-coupled receptorsLymphoid folliclesFollicle centersT cellsVirus infectionInterfollicular regionsMice LackingEBI2FolliclesMolecular cuesReceptorsCellsCorrect positioning