2018
Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development
Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP. Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development. Journal Of Experimental Medicine 2018, 215: 2586-2599. PMID: 30158115, PMCID: PMC6170173, DOI: 10.1084/jem.20180778.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChemokine CXCL12Interleukin-7Mesenchymal Stem CellsMiceMice, KnockoutPrecursor Cells, B-LymphoidReceptors, Interleukin-7Signal TransductionConceptsB cell progenitorsCell progenitorsUnrepaired double-strand DNA breaksDouble-strand DNA breaksB cell developmentMesenchymal progenitor cellsInterleukin-7IL-7R signalingFocal adhesion kinase expressionBone marrow stromal cellsCell movementMarrow stromal cellsDNA breaksPreB cellsCell developmentParacrine signalsCell behaviorAcute lymphoblastic leukemic cellsProgenitor cellsKinase expressionProgenitorsIL-7RCell exposureStromal cellsLow-adhesion state
2015
Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis
Nevius E, Pinho F, Dhodapkar M, Jin H, Nadrah K, Horowitz MC, Kikuta J, Ishii M, Pereira JP. Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. Journal Of Experimental Medicine 2015, 212: 1931-1946. PMID: 26438360, PMCID: PMC4612084, DOI: 10.1084/jem.20150088.Peer-Reviewed Original ResearchConceptsOC precursorsBone surfaceEstrogen deficiency-induced osteoporosisBone mass homeostasisCell-cell interactionsTime-lapse microscopyBone metastatic cancerSignificant therapeutic potentialOxysterol ligandsFemale miceMale miceBone massMetastatic cancerLarge osteoclastsEBI2Nonhematopoietic cellsNovel pathwayTherapeutic potentialOsteoclastsTwo-photon microscopyMiceOsteoblastsVivoCellsOsteoporosisImmature B Cell Egress from Bone Marrow Is SOCS3 Independent
Nadrah K, Beck TC, Pereira JP. Immature B Cell Egress from Bone Marrow Is SOCS3 Independent. PLOS ONE 2015, 10: e0136061. PMID: 26274929, PMCID: PMC4537204, DOI: 10.1371/journal.pone.0136061.Peer-Reviewed Original ResearchConceptsB cell subsetsBone marrowBM parenchymaCell subsetsImmature-B cell egressB cell egressImmature B cell subsetsB cell distributionB lymphocyte subsetsCXCR4 desensitizationSuppressor of cytokineLymphocyte subsetsSOCS3 deficiencyPeripheral bloodSOCS3 deletionB lineage cellsB-lineage lymphocytesB cellsB cell developmentCXCR4Cell egressLigand exposureSOCS3Significant differencesHuman cell lines
2014
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow
Beck TC, Gomes AC, Cyster JG, Pereira JP. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. Journal Of Experimental Medicine 2014, 211: 2567-2581. PMID: 25403444, PMCID: PMC4267240, DOI: 10.1084/jem.20140457.Peer-Reviewed Original ResearchConceptsGαi protein-coupled receptorsBone marrowCell egressImmature-B cell egressB cell egressTwo-photon intravital microscopyB cell retentionImmature B cellsBM parenchymaProtein-coupled receptorsNK cellsB lineage cellsImmature BLymphoid organsVCAM-1Pertussis toxinB cellsSinusoidal endotheliumIntravital microscopyCXCR4Lineage cellsHematopoietic cellsMarrowCellsMotility
2010
A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow
Pereira JP, Cyster J, Xu Y. A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow. PLOS ONE 2010, 5: e9277. PMID: 20174580, PMCID: PMC2823786, DOI: 10.1371/journal.pone.0009277.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesBone MarrowBromodeoxyuridineCell MovementChemotaxis, LeukocyteFemaleFingolimod HydrochlorideImmunosuppressive AgentsLysophospholipidsMaleMiceMice, Inbred C57BLMice, Inbred CBAMice, KnockoutMice, TransgenicPrecursor Cells, B-LymphoidPropylene GlycolsReceptors, LysosphingolipidReverse Transcriptase Polymerase Chain ReactionSignal TransductionSphingosine