2016
Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation
Gomes A, Hara T, Lim VY, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP. Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Immunity 2016, 45: 1219-1231. PMID: 27913094, PMCID: PMC5538583, DOI: 10.1016/j.immuni.2016.11.004.Peer-Reviewed Original ResearchConceptsCommon lymphoid progenitorsHematopoietic stem cellsMesenchymal progenitorsProgenitor differentiationHSC nicheCell lineage decisionsBone marrow nicheHSC maintenanceLineage decisionsDifferentiation signalsCytokines SCFEndothelial cellsSeparate nichesLymphoid progenitorsMultilineage differentiationMarrow nicheNicheChemokine receptor CXCR4Conditional deletionIL-7 receptorStem cellsProgenitorsDifferentiationIL-7Deletion
2011
EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues
Kelly LM, Pereira JP, Yi T, Xu Y, Cyster JG. EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues. The Journal Of Immunology 2011, 187: 3026-3032. PMID: 21844396, PMCID: PMC3169736, DOI: 10.4049/jimmunol.1101262.Peer-Reviewed Original ResearchConceptsActivated B cellsB cellsAb responsesNonlymphoid tissuesCCR7-dependent mannerSecondary lymphoid organsDependent Ab responsesB cell migrationLigand activityCCR7 downregulationLymphoid organsFollicular regionsEBI2Outer follicleT zoneCD40 engagementCell linesLipid ligandsLymphoidCell migrationGene 2CellsTissueSerial movementsEarly wave