2018
Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development
Fistonich C, Zehentmeier S, Bednarski JJ, Miao R, Schjerven H, Sleckman BP, Pereira JP. Cell circuits between B cell progenitors and IL-7+ mesenchymal progenitor cells control B cell development. Journal Of Experimental Medicine 2018, 215: 2586-2599. PMID: 30158115, PMCID: PMC6170173, DOI: 10.1084/jem.20180778.Peer-Reviewed Original ResearchConceptsB cell progenitorsCell progenitorsUnrepaired double-strand DNA breaksDouble-strand DNA breaksB cell developmentMesenchymal progenitor cellsInterleukin-7IL-7R signalingFocal adhesion kinase expressionBone marrow stromal cellsCell movementMarrow stromal cellsDNA breaksPreB cellsCell developmentParacrine signalsCell behaviorAcute lymphoblastic leukemic cellsProgenitor cellsKinase expressionProgenitorsIL-7RCell exposureStromal cellsLow-adhesion state
2015
Immature B Cell Egress from Bone Marrow Is SOCS3 Independent
Nadrah K, Beck TC, Pereira JP. Immature B Cell Egress from Bone Marrow Is SOCS3 Independent. PLOS ONE 2015, 10: e0136061. PMID: 26274929, PMCID: PMC4537204, DOI: 10.1371/journal.pone.0136061.Peer-Reviewed Original ResearchConceptsB cell subsetsBone marrowBM parenchymaCell subsetsImmature-B cell egressB cell egressImmature B cell subsetsB cell distributionB lymphocyte subsetsCXCR4 desensitizationSuppressor of cytokineLymphocyte subsetsSOCS3 deficiencyPeripheral bloodSOCS3 deletionB lineage cellsB-lineage lymphocytesB cellsB cell developmentCXCR4Cell egressLigand exposureSOCS3Significant differencesHuman cell lines