2016
Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation
Gomes A, Hara T, Lim VY, Herndler-Brandstetter D, Nevius E, Sugiyama T, Tani-ichi S, Schlenner S, Richie E, Rodewald HR, Flavell RA, Nagasawa T, Ikuta K, Pereira JP. Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation. Immunity 2016, 45: 1219-1231. PMID: 27913094, PMCID: PMC5538583, DOI: 10.1016/j.immuni.2016.11.004.Peer-Reviewed Original ResearchConceptsCommon lymphoid progenitorsHematopoietic stem cellsMesenchymal progenitorsProgenitor differentiationHSC nicheCell lineage decisionsBone marrow nicheHSC maintenanceLineage decisionsDifferentiation signalsCytokines SCFEndothelial cellsSeparate nichesLymphoid progenitorsMultilineage differentiationMarrow nicheNicheChemokine receptor CXCR4Conditional deletionIL-7 receptorStem cellsProgenitorsDifferentiationIL-7Deletion
2015
Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis
Nevius E, Pinho F, Dhodapkar M, Jin H, Nadrah K, Horowitz MC, Kikuta J, Ishii M, Pereira JP. Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis. Journal Of Experimental Medicine 2015, 212: 1931-1946. PMID: 26438360, PMCID: PMC4612084, DOI: 10.1084/jem.20150088.Peer-Reviewed Original ResearchConceptsOC precursorsBone surfaceEstrogen deficiency-induced osteoporosisBone mass homeostasisCell-cell interactionsTime-lapse microscopyBone metastatic cancerSignificant therapeutic potentialOxysterol ligandsFemale miceMale miceBone massMetastatic cancerLarge osteoclastsEBI2Nonhematopoietic cellsNovel pathwayTherapeutic potentialOsteoclastsTwo-photon microscopyMiceOsteoblastsVivoCellsOsteoporosis
2014
CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow
Beck TC, Gomes AC, Cyster JG, Pereira JP. CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow. Journal Of Experimental Medicine 2014, 211: 2567-2581. PMID: 25403444, PMCID: PMC4267240, DOI: 10.1084/jem.20140457.Peer-Reviewed Original ResearchConceptsGαi protein-coupled receptorsBone marrowCell egressImmature-B cell egressB cell egressTwo-photon intravital microscopyB cell retentionImmature B cellsBM parenchymaProtein-coupled receptorsNK cellsB lineage cellsImmature BLymphoid organsVCAM-1Pertussis toxinB cellsSinusoidal endotheliumIntravital microscopyCXCR4Lineage cellsHematopoietic cellsMarrowCellsMotility
2011
EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues
Kelly LM, Pereira JP, Yi T, Xu Y, Cyster JG. EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues. The Journal Of Immunology 2011, 187: 3026-3032. PMID: 21844396, PMCID: PMC3169736, DOI: 10.4049/jimmunol.1101262.Peer-Reviewed Original ResearchConceptsActivated B cellsB cellsAb responsesNonlymphoid tissuesCCR7-dependent mannerSecondary lymphoid organsDependent Ab responsesB cell migrationLigand activityCCR7 downregulationLymphoid organsFollicular regionsEBI2Outer follicleT zoneCD40 engagementCell linesLipid ligandsLymphoidCell migrationGene 2CellsTissueSerial movementsEarly wave
2010
A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow
Pereira JP, Cyster J, Xu Y. A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow. PLOS ONE 2010, 5: e9277. PMID: 20174580, PMCID: PMC2823786, DOI: 10.1371/journal.pone.0009277.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsB-LymphocytesBone MarrowBromodeoxyuridineCell MovementChemotaxis, LeukocyteFemaleFingolimod HydrochlorideImmunosuppressive AgentsLysophospholipidsMaleMiceMice, Inbred C57BLMice, Inbred CBAMice, KnockoutMice, TransgenicPrecursor Cells, B-LymphoidPropylene GlycolsReceptors, LysosphingolipidReverse Transcriptase Polymerase Chain ReactionSignal TransductionSphingosine
2009
EBI2 mediates B cell segregation between the outer and centre follicle
Pereira JP, Kelly LM, Xu Y, Cyster JG. EBI2 mediates B cell segregation between the outer and centre follicle. Nature 2009, 460: 1122-1126. PMID: 19597478, PMCID: PMC2809436, DOI: 10.1038/nature08226.Peer-Reviewed Original ResearchConceptsB cellsAntibody responseEpstein-Barr virus infectionOrphan G protein-coupled receptorOuter follicleB cell segregationNormal B cell proliferationDefective antibody responsesB cell positioningGerminal center B cellsActivated B cellsB cell proliferationG protein-coupled receptorsLymphoid folliclesFollicle centersT cellsVirus infectionInterfollicular regionsMice LackingEBI2FolliclesMolecular cuesReceptorsCellsCorrect positioningCannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids
Pereira JP, An J, Xu Y, Huang Y, Cyster JG. Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Nature Immunology 2009, 10: 403-411. PMID: 19252491, PMCID: PMC2768754, DOI: 10.1038/ni.1710.Peer-Reviewed Original Research
2007
Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate
Pappu R, Schwab SR, Cornelissen I, Pereira J, Regard JB, Xu Y, Camerer E, Zheng YW, Huang Y, Cyster JG, Coughlin SR. Promotion of Lymphocyte Egress into Blood and Lymph by Distinct Sources of Sphingosine-1-Phosphate. Science 2007, 316: 295-298. PMID: 17363629, DOI: 10.1126/science.1139221.Peer-Reviewed Original Research
2005
Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients
Schwab SR, Pereira J, Matloubian M, Xu Y, Huang Y, Cyster JG. Lymphocyte Sequestration Through S1P Lyase Inhibition and Disruption of S1P Gradients. Science 2005, 309: 1735-1739. PMID: 16151014, DOI: 10.1126/science.1113640.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde-LyasesAnimalsB-LymphocytesChemotaxis, LeukocyteEnzyme InhibitorsFood Coloring AgentsHematopoietic Stem CellsImidazolesImmunosuppressive AgentsLymphLymph NodesLymphoid TissueLymphopeniaLysophospholipidsMiceMice, Inbred C57BLPyridoxineReceptors, LysosphingolipidRNA InterferenceSphingosineThymus GlandT-LymphocytesVitamin B 6