1998
Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 2. Reactivity and Nucleotide Binding Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3 and [{PtCl(diamine)}2(L-L)](NO3)2 (L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative) in Relation to Their Cytotoxicity
Bierbach U, Roberts J, Farrell N. Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 2. Reactivity and Nucleotide Binding Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3 and [{PtCl(diamine)}2(L-L)](NO3)2 (L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative) in Relation to Their Cytotoxicity. Inorganic Chemistry 1998, 37: 717-723. DOI: 10.1021/ic970421q.Peer-Reviewed Original ResearchAntitumor complexesAqueous solution chemistryDinuclear complexes 3Dinuclear compound 3NMR chemical shiftsN-type conformationComplexes 3Thiourea ligandsCationic complexesSulfur ligandsNMR spectroscopyChemical shiftsSolution chemistryDinuclear adductsIntramolecular disproportionationAnalogous reactionCompound 3Aqueous solutionMonofunctional adductsBifunctional adductsRate of hydrolysisAdductsBinding propertiesChemistryCytotoxicity data
1992
Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action.
Farrell N, Kelland LR, Roberts JD, Van Beusichem M. Activation of the trans geometry in platinum antitumor complexes: a survey of the cytotoxicity of trans complexes containing planar ligands in murine L1210 and human tumor panels and studies on their mechanism of action. Cancer Research 1992, 52: 5065-72. PMID: 1516063.Peer-Reviewed Original ResearchConceptsPlatinum antitumor complexesPlanar ligandsPyridine complexesAmmine complexesAntitumor complexesNew trans platinum complexesCell linesHuman tumor cell linesTrans-platinum complexesTumor cell linesPreliminary mechanistic studiesMurine L1210Rate of reactionFormula transMechanism of actionTrans complexesTrans geometryImportant biomoleculesSteric hindranceThymus DNAHuman tumor panelOvarian carcinoma cell linesCarcinoma cell linesPotential new classDNA synthesis
1988
ChemInform Abstract: Water Soluble DACH‐Pt(II) Complexes: Problems of Purification; Stability of Complexes with Nitrogen‐Containing Ligands.
ROBERTS J, SCHMIDT W, TONG W, HACKER M. ChemInform Abstract: Water Soluble DACH‐Pt(II) Complexes: Problems of Purification; Stability of Complexes with Nitrogen‐Containing Ligands. ChemInform 1988, 19: no-no. DOI: 10.1002/chin.198852282.Peer-Reviewed Original ResearchWater soluble DACHPt(II) complexes: Problems of purification; Stability of complexes with nitrogen-containing ligands
Roberts J, Schmidt W, Tong W, Hacker M. Water soluble DACHPt(II) complexes: Problems of purification; Stability of complexes with nitrogen-containing ligands. Inorganica Chimica Acta 1988, 153: 123-127. DOI: 10.1016/s0020-1693(00)83870-0.Peer-Reviewed Original ResearchNitrogen-containing ligandsStability of complexesTypes of complexesDicarboxylato ligandsTridentate bondingAntitumor complexesProblem of purificationAqueous solutionChemical identificationChemical formulationFurther purificationComplexesBiological systemsLigandsPurificationResidual impuritiesWaterPlatinumBondingPurityImpuritiesStabilitySolution