1998
Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 2. Reactivity and Nucleotide Binding Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3 and [{PtCl(diamine)}2(L-L)](NO3)2 (L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative) in Relation to Their Cytotoxicity
Bierbach U, Roberts J, Farrell N. Modification of Platinum(II) Antitumor Complexes with Sulfur Ligands. 2. Reactivity and Nucleotide Binding Properties of Cationic Complexes of the Types [PtCl(diamine)(L)]NO3 and [{PtCl(diamine)}2(L-L)](NO3)2 (L = Monofunctional Thiourea Derivative; L-L = Bifunctional Thiourea Derivative) in Relation to Their Cytotoxicity. Inorganic Chemistry 1998, 37: 717-723. DOI: 10.1021/ic970421q.Peer-Reviewed Original ResearchAntitumor complexesAqueous solution chemistryDinuclear complexes 3Dinuclear compound 3NMR chemical shiftsN-type conformationComplexes 3Thiourea ligandsCationic complexesSulfur ligandsNMR spectroscopyChemical shiftsSolution chemistryDinuclear adductsIntramolecular disproportionationAnalogous reactionCompound 3Aqueous solutionMonofunctional adductsBifunctional adductsRate of hydrolysisAdductsBinding propertiesChemistryCytotoxicity data
1991
Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato)platinum(II). Evidence for a novel rearrangement involving platinum—carbon bond formation
Farrell N, Roberts J, Hacker M, Farrell N, Roberts J, Hacker M. Shikimic acid complexes of platinum. Preparation, reactivity, and antitumor activity of (R,R-1,2-diaminocyclohexane) bis(shikimato)platinum(II). Evidence for a novel rearrangement involving platinum—carbon bond formation. Journal Of Inorganic Biochemistry 1991, 42: 237-246. PMID: 1880505, DOI: 10.1016/0162-0134(91)84038-b.Peer-Reviewed Original ResearchConceptsHigh-performance liquid chromatographyCarboxylate oxygenVinylic carbonBond formationAqueous solutionPerformance liquid chromatographyAcid complexesL1210 cell lineLiquid chromatographyHydrolysis productsComplexesComplex IIMajor hydrolysis productsL1210 leukemiaNovel rearrangementMoietyAntitumor activityPlatinumChromatographyReactivityOxygenPreparationCarbonComplex typeFormation
1988
Water soluble DACHPt(II) complexes: Problems of purification; Stability of complexes with nitrogen-containing ligands
Roberts J, Schmidt W, Tong W, Hacker M. Water soluble DACHPt(II) complexes: Problems of purification; Stability of complexes with nitrogen-containing ligands. Inorganica Chimica Acta 1988, 153: 123-127. DOI: 10.1016/s0020-1693(00)83870-0.Peer-Reviewed Original ResearchNitrogen-containing ligandsStability of complexesTypes of complexesDicarboxylato ligandsTridentate bondingAntitumor complexesProblem of purificationAqueous solutionChemical identificationChemical formulationFurther purificationComplexesBiological systemsLigandsPurificationResidual impuritiesWaterPlatinumBondingPurityImpuritiesStabilitySolution