2011
Phase II Trials Powered to Detect Tumor Subtypes
Roberts JD, Ramakrishnan V. Phase II Trials Powered to Detect Tumor Subtypes. Clinical Cancer Research 2011, 17: 5538-5545. PMID: 21737510, DOI: 10.1158/1078-0432.ccr-10-2466.Peer-Reviewed Original ResearchConceptsTumor subtypesResponse ratePhase II trial designPhase II trialPhase III trialsOverall response ratePhase II designStage 1Characterization of tumorsII trialIII trialsMetastatic diseaseSimilar patientsProspective characterizationSample sizeTrial designSubtypesTumorsTotal sample sizePhase IIII designTrialsTreatmentVariables of interestDifferent treatments
1989
Effect of tamoxifen on plasma insulin-like growth factor I in patients with breast cancer.
Colletti RB, Roberts JD, Devlin JT, Copeland KC. Effect of tamoxifen on plasma insulin-like growth factor I in patients with breast cancer. Cancer Research 1989, 49: 1882-4. PMID: 2924327.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor IBreast cancer patientsGrowth factor ICancer patientsPlasma IGFBreast cancerAmbulatory breast cancer patientsPlasma insulin-like growth factor IFactor IPlasma IGF-I concentrationsPlasma IGF-I levelsAntiestrogen agent tamoxifenRecent weight lossIGF-I levelsEffect of tamoxifenIGF-I concentrationsHuman breast cancer cellsSuppression of IGFGrowth hormone-dependent peptideBreast cancer cellsMetastatic diseasePlasma concentrationsPatientsTamoxifenNutritional status