2021
Non-crisis related pain occurs in adult patients with sickle cell disease despite chronic red blood cell exchange transfusion therapy
Curtis SA, Raisa BM, Roberts JD, Hendrickson JE, Starrels J, Lesley D, Michelle D, Daniel Z, Brandow AM. Non-crisis related pain occurs in adult patients with sickle cell disease despite chronic red blood cell exchange transfusion therapy. Transfusion And Apheresis Science 2021, 61: 103304. PMID: 34782244, PMCID: PMC9838733, DOI: 10.1016/j.transci.2021.103304.Peer-Reviewed Original ResearchConceptsChronic exchange transfusionsHealth care utilizationCare utilizationExchange transfusionPain impactDisease characteristicsChronic red blood cell transfusionsRed blood cell transfusionLower health care utilizationSickle Cell Disease PainExchange transfusion therapyAcute care utilizationBlood cell transfusionSimilar disease characteristicsPatient-reported outcomesLength of staySickle cell diseaseQuality of lifeCause admissionsCell transfusionNeuropathic painOpioid prescriptionsWorst painAcute painAdult patients
2020
Daily Cannabis Users with Sickle Cell Disease Show Fewer Admissions than Others with Similar Pain Complaints
Curtis SA, Brandow AM, DeVeaux M, Zeltermam D, Devine L, Roberts JD. Daily Cannabis Users with Sickle Cell Disease Show Fewer Admissions than Others with Similar Pain Complaints. Cannabis And Cannabinoid Research 2020, 5: 255-262. PMID: 32923662, PMCID: PMC7480712, DOI: 10.1089/can.2019.0036.Peer-Reviewed Original ResearchSickle cell diseaseDaily cannabis usersAnnual emergency room visitsSevere pain crisesEmergency room visitsHealth care utilizationCannabis usersCross-sectional studyPatient-reported measuresQuality of lifeSimilar disease severityHydroxyurea usePain crisisPain complaintsHospital admissionCare utilizationRoom visitsPain impactSeverity scoreDisease showAnnual admissionsCell diseaseER useDaily cannabisDisease severity
2019
Baseline Pain in Adults with Sickle Cell Disease Can be Neuropathic or Nociceptive and Outcomes Differ between Pain Types
Curtis S, Forray A, Hendrickson J, Roberts J. Baseline Pain in Adults with Sickle Cell Disease Can be Neuropathic or Nociceptive and Outcomes Differ between Pain Types. Blood 2019, 134: 1028. DOI: 10.1182/blood-2019-129106.Peer-Reviewed Original ResearchSickle cell diseaseNeuropathic pain qualitiesNeuropathic painNociceptive painPain impactBaseline painED usePain qualityWorse sleepOpioid usePain groupChronic painCell diseaseEpisode frequencyOutcomes Measurement Information System (PROMIS) domainsAdult Sickle Cell QualityAverage daily opioid useHigher C-reactive proteinYale-New Haven HospitalHigh ED useWorse clinical outcomesC-reactive proteinDaily opioid useEmergency department useHalf of adults