2021
Non-crisis related pain occurs in adult patients with sickle cell disease despite chronic red blood cell exchange transfusion therapy
Curtis SA, Raisa BM, Roberts JD, Hendrickson JE, Starrels J, Lesley D, Michelle D, Daniel Z, Brandow AM. Non-crisis related pain occurs in adult patients with sickle cell disease despite chronic red blood cell exchange transfusion therapy. Transfusion And Apheresis Science 2021, 61: 103304. PMID: 34782244, PMCID: PMC9838733, DOI: 10.1016/j.transci.2021.103304.Peer-Reviewed Original ResearchConceptsChronic exchange transfusionsHealth care utilizationCare utilizationExchange transfusionPain impactDisease characteristicsChronic red blood cell transfusionsRed blood cell transfusionLower health care utilizationSickle Cell Disease PainExchange transfusion therapyAcute care utilizationBlood cell transfusionSimilar disease characteristicsPatient-reported outcomesLength of staySickle cell diseaseQuality of lifeCause admissionsCell transfusionNeuropathic painOpioid prescriptionsWorst painAcute painAdult patients
2020
Daily Cannabis Users with Sickle Cell Disease Show Fewer Admissions than Others with Similar Pain Complaints
Curtis SA, Brandow AM, DeVeaux M, Zeltermam D, Devine L, Roberts JD. Daily Cannabis Users with Sickle Cell Disease Show Fewer Admissions than Others with Similar Pain Complaints. Cannabis And Cannabinoid Research 2020, 5: 255-262. PMID: 32923662, PMCID: PMC7480712, DOI: 10.1089/can.2019.0036.Peer-Reviewed Original ResearchSickle cell diseaseDaily cannabis usersAnnual emergency room visitsSevere pain crisesEmergency room visitsHealth care utilizationCannabis usersCross-sectional studyPatient-reported measuresQuality of lifeSimilar disease severityHydroxyurea usePain crisisPain complaintsHospital admissionCare utilizationRoom visitsPain impactSeverity scoreDisease showAnnual admissionsCell diseaseER useDaily cannabisDisease severityMedical marijuana certification for patients with sickle cell disease: a report of a single center experience
Curtis SA, Lew D, Spodick J, Hendrickson JE, Minniti CP, Roberts JD. Medical marijuana certification for patients with sickle cell disease: a report of a single center experience. Blood Advances 2020, 4: 3814-3821. PMID: 32790846, PMCID: PMC7448584, DOI: 10.1182/bloodadvances.2020002325.Peer-Reviewed Original ResearchConceptsOpioid useMedical marijuanaSickle cell disease (SCD) reportBaseline opioid useSingle-center experienceHealth care utilizationSickle cell diseaseOpioid utilizationClinical characteristicsMost patientsCenter experienceCare utilizationSCD patientsInpatient hospitalizationRandom patientsAdmission ratesCell diseasePatientsRetrospective dataDisease reportsStudy periodHealth careCannabis productsCannabisEdible cannabis productsBuilding access to care in adult sickle cell disease: defining models of care, essential components, and economic aspects
Kanter J, Smith WR, Desai PC, Treadwell M, Andemariam B, Little J, Nugent D, Claster S, Manwani DG, Baker J, Strouse JJ, Osunkwo I, Stewart RW, King A, Shook LM, Roberts JD, Lanzkron S. Building access to care in adult sickle cell disease: defining models of care, essential components, and economic aspects. Blood Advances 2020, 4: 3804-3813. PMID: 32785684, PMCID: PMC7448595, DOI: 10.1182/bloodadvances.2020001743.Peer-Reviewed Original ResearchConceptsSickle cell diseaseSCD centerCell diseaseAdult sickle cell diseaseAcute care utilizationManagement of adultsModel of careSickle cell careHealth care professionalsHealth system levelSCD guidelinesMultisystem illnessSCD careCare utilizationEarly mortalityCenter designationClinical effectivenessClinical centersCare professionalsHematology providersMore cliniciansCare deliveryMost childrenBlood disordersCareUtilization, financial outcomes and stakeholder perspectives of a re-organized adult sickle cell program
Rousseau R, Weisberg DF, Gorero J, Parwani V, Bozzo J, Kenyon K, Smith C, Cole J, Curtis S, Forray A, Roberts JD. Utilization, financial outcomes and stakeholder perspectives of a re-organized adult sickle cell program. PLOS ONE 2020, 15: e0236360. PMID: 32706825, PMCID: PMC7380627, DOI: 10.1371/journal.pone.0236360.Peer-Reviewed Original ResearchConceptsSickle cell diseaseCell diseaseYale-New Haven HospitalAcute care servicesCare of adultsPoor socio-economic statusPersonalized care planSickle Cell ProgramNew Haven HospitalSingle nursing unitParenteral opioidsPain controlClinic visitsMost patientsPain managementChronic painOutpatient visitsPrimary complaintEmergency departmentPrimary careInpatient daysCare plansCare servicesSocio-economic statusNursing units
2019
Baseline Pain in Adults with Sickle Cell Disease Can be Neuropathic or Nociceptive and Outcomes Differ between Pain Types
Curtis S, Forray A, Hendrickson J, Roberts J. Baseline Pain in Adults with Sickle Cell Disease Can be Neuropathic or Nociceptive and Outcomes Differ between Pain Types. Blood 2019, 134: 1028. DOI: 10.1182/blood-2019-129106.Peer-Reviewed Original ResearchSickle cell diseaseNeuropathic pain qualitiesNeuropathic painNociceptive painPain impactBaseline painED usePain qualityWorse sleepOpioid usePain groupChronic painCell diseaseEpisode frequencyOutcomes Measurement Information System (PROMIS) domainsAdult Sickle Cell QualityAverage daily opioid useHigher C-reactive proteinYale-New Haven HospitalHigh ED useWorse clinical outcomesC-reactive proteinDaily opioid useEmergency department useHalf of adultsCase Management Featuring Community Health Workers Reduces Inpatient Health Care Utilization in Adults with Sickle Cell Disease
Smith W, Sop D, Johnson S, Lipato T, Ferlis M, Mcmanus C, Guy M, Hartigan S, Holt E, McHenry C, Roberts J. Case Management Featuring Community Health Workers Reduces Inpatient Health Care Utilization in Adults with Sickle Cell Disease. Blood 2019, 134: 2104. DOI: 10.1182/blood-2019-130441.Peer-Reviewed Original ResearchVirginia Commonwealth University Medical CenterCommunity health workersAdvanced practice providersSickle cell diseaseReadmission ratesInpatient daysCase managementSCD adultsOutpatient visitsCare utilizationHigh utilizersMedical homeCell diseaseHealth workersInpatient health care utilizationAdult SCD patientsED return rateAcute care utilizationHospital readmission ratesHealth care utilizationEmergency department managementNumber of patientsTotal inpatient daysPatient-provider relationshipTruven Health AnalyticsStatewide Intervention to Improve Medical Care Services Utilization Patterns of Adults Living with Sickle Cell Disease
Roberts J, Andemariam B, Bozzo J, Du C, Curtis S, Latham D, Cyr M, Magras L. Statewide Intervention to Improve Medical Care Services Utilization Patterns of Adults Living with Sickle Cell Disease. Blood 2019, 134: 517. DOI: 10.1182/blood-2019-124462.Peer-Reviewed Original ResearchSickle cell diseaseED/hospitalCommunity health networksED visitsED visit ratesEmergency departmentHospital visitsClinical team membersCell diseaseHealth NetworkHospitalization ratesHospital utilizationVisit ratesAdvisory CommitteeUtilization dataICD-9/ICDInstitutional review board approvalMedicaid programAmbulatory care servicesService utilization patternsTruven Health AnalyticsAge 16 yearsQuality improvement projectReview board approvalMann-Whitney U testInpatient pain management in sickle cell disease
Zassman SM, Zamora FJ, Roberts JD. Inpatient pain management in sickle cell disease. American Journal Of Health-System Pharmacy 2019, 76: 1965-1971. PMID: 31605120, DOI: 10.1093/ajhp/zxz228.Peer-Reviewed Original ResearchVaso-occlusive crisisSickle cell diseasePatient-controlled analgesiaOral opioidsParenteral opioidsAcute painPain controlCell diseaseAverage daily pain scoreDaily pain scoresInpatient pain managementAdequate pain controlEmergency department visitsInherited blood disorderOral regimenOpioid usagePain scoresSevere painDepartment visitsHospital admissionPain managementIncremental dosesOpioidsCommon reasonPatientsRed blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease
Balbuena‐Merle R, Curtis SA, Devine L, Gibb DR, Karafin MS, Luckey CJ, Tormey CA, Siddon AJ, Roberts JD, Hendrickson JE. Red blood cell alloimmunization is associated with lower expression of FcγR1 on monocyte subsets in patients with sickle cell disease. Transfusion 2019, 59: 3219-3227. PMID: 31355970, PMCID: PMC7075520, DOI: 10.1111/trf.15463.Peer-Reviewed Original ResearchConceptsSickle cell diseaseMonocyte subsetsTotal monocytesCell diseaseComplications of SCDRed blood cell alloimmunizationRed blood cell alloantibodiesElectronic medical recordsTransfusion exposureSerum cytokinesIntermediate monocytesRBC alloantibodiesInflammatory milieuCD64 expressionClassical monocytesPeripheral bloodInflammatory functionsMedical recordsAntibody formationClinical significancePatientsMonocytesFlow cytometryLow expressionResponders
2018
Medical Marijuana Certification for Patients with Sickle Cell Disease: A Survey Study of Patient's Use and Preferences
Curtis S, Spodick J, Lew D, Roberts J. Medical Marijuana Certification for Patients with Sickle Cell Disease: A Survey Study of Patient's Use and Preferences. Blood 2018, 132: 1094. DOI: 10.1182/blood-2018-99-118345.Peer-Reviewed Original ResearchMedical marijuanaOpioid useExact testSickle cell disease clinicMarijuana usePain medication useLess pain medicationEfficacy of marijuanaSickle cell diseaseFisher's exact testImproved safety profileMedical marijuana certificationSCD clinicPain medicationAdult patientsClinic visitsDisease clinicMedication useSymptom managementLess painSafety profileLung toxicityCell diseaseOpiate usePatientsElevated Levels of CD64 MFI on Monocyte Subsets Are Associated with a History of Stroke in Sickle Cell Disease
Curtis S, Balbuena-Merle R, Devine L, Zelterman D, Roberts J, Dearborn-Tomazos J, Sansing L, Hendrickson J. Elevated Levels of CD64 MFI on Monocyte Subsets Are Associated with a History of Stroke in Sickle Cell Disease. Blood 2018, 132: 1093. DOI: 10.1182/blood-2018-99-117504.Peer-Reviewed Original ResearchHistory of strokeSickle cell diseaseRole of monocytesIschemic strokeTotal neutrophil countComplete blood countMonocyte subsetsStroke historyNeutrophil countIntermediate monocytesMonocyte subtypesBlood countClassical monocytesCell diseaseFuture stroke riskIschemic stroke historyVaso-occlusive crisisPro-inflammatory monocytesPathophysiology of strokeCause of morbidityMultivariate logistic regressionNon-classical monocytesT-testHigh-affinity receptorStudent's t-testMedical Marijuana for Sickle Cell Disease: Results of Two Years of Certification in an Adult Sickle Cell Center
Curtis S, Lew D, Spodick J, Roberts J. Medical Marijuana for Sickle Cell Disease: Results of Two Years of Certification in an Adult Sickle Cell Center. Blood 2018, 132: 858. DOI: 10.1182/blood-2018-99-118290.Peer-Reviewed Original ResearchSickle cell diseaseAcute service utilizationOral morphine equivalentsPrevious marijuana useOpioid useDaily opioid useService utilizationHospital admissionAdmission ratesHydroxyurea useChronic painInsurance typeAcute servicesCell diseaseAcute care service utilizationTotal oral morphine equivalentsBaseline opioid useRegular clinic visitsPrescription monitoring programsMarijuana useSickle Cell CenterOnly clinical differenceQuality of lifeT-testElectronic medical recordsMarijuana Use in Adults Living with Sickle Cell Disease
Roberts JD, Spodick J, Cole J, Bozzo J, Curtis S, Forray A. Marijuana Use in Adults Living with Sickle Cell Disease. Cannabis And Cannabinoid Research 2018, 3: 162-165. PMID: 30014039, PMCID: PMC6044416, DOI: 10.1089/can.2018.0001.Peer-Reviewed Original ResearchSickle cell diseaseCell diseaseMedical marijuanaMarijuana useUrine drug testsPossible therapeutic effectsUrine drug testingAcademic medical centerTertiary careTherapeutic effectMedical CenterPatient's requestPatientsDiseaseQualifying conditionsDrug testsDrug testingCannabinoidsActive constituentsMarijuanaMedicinal indicationsPhencyclidineAdultsInstitutional recordsRecreational use
2017
Predictive Ability of Intermittent Daily Sickle Cell Pain Assessment: The PiSCES Project
Smith WR, McClish DK, Levenson J, Aisiku I, Dahman B, Bovbjerg VE, Roseff S, Roberts J. Predictive Ability of Intermittent Daily Sickle Cell Pain Assessment: The PiSCES Project. Pain Medicine 2017, 19: 1972-1981. PMID: 29036363, PMCID: PMC6176749, DOI: 10.1093/pm/pnx214.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain daysPain assessmentPain measuresOne weekGold standardSickle Cell Epidemiology StudyMonths strategyDaily pain assessmentProspective cohort studyOne dayPiSCES projectCohort studySCD patientsMeasurement of R2Month assessmentCell diseasePainEpidemiology studiesDiary assessmentsDaily assessmentIntermittent assessmentCrisis daysWeeksMonths
2015
Daily home opioid use in adults with sickle cell disease: The PiSCES project.
Smith WR, McClish DK, Dahman BA, Levenson JL, Aisiku IP, de A Citero V, Bovbjerg VE, Roberts JD, Penberthy LT, Roseff SD. Daily home opioid use in adults with sickle cell disease: The PiSCES project. Journal Of Opioid Management 2015, 11: 243-53. PMID: 25985809, DOI: 10.5055/jom.2015.0273.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdaptation, PsychologicalAdolescentAdultAnalgesics, OpioidAnemia, Sickle CellAntisickling AgentsCost of IllnessDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansHydroxyureaLongitudinal StudiesMaleMiddle AgedPainPain MeasurementQuality of LifeSelf AdministrationTime FactorsTreatment OutcomeYoung AdultConceptsSickle cell diseaseHome opioid useOpioid usePain daysOpioid usersMean painCell diseasePsychosocial variablesDaily pain diaryMajority of patientsNon-opioid analgesicsSomatic symptom burdenPiSCES projectOpioid prescribingPain frequencyCohort studySymptom burdenPain diaryPain intensityPatient characteristicsPhysical QoLOpioidsPatientsSCD samplesSimilar association
2012
Pain and disease severity relate to long versus short-acting opioid use in adults with sickle cell disease: the PiSCES project
Smith W, McClish D, Dahman B, Levenson J, Aisiku I, Citero V, Bovbjerg V, Roberts J, Penberthy L, Roseff S, Scherer M, Weaver M. Pain and disease severity relate to long versus short-acting opioid use in adults with sickle cell disease: the PiSCES project. Journal Of Pain 2012, 13: s15. DOI: 10.1016/j.jpain.2012.01.067.Peer-Reviewed Original ResearchHome opioid use in sickle cell disease and relationship to pain and psychosocial variables: the PiSCES project
Smith W, McClish D, Dahman B, Levenson J, Aisiku I, Citero V, Bovbjerg V, Roberts J, Penberthy L, Roseff S, Scherer M, Weaver M. Home opioid use in sickle cell disease and relationship to pain and psychosocial variables: the PiSCES project. Journal Of Pain 2012, 13: s13. DOI: 10.1016/j.jpain.2012.01.060.Peer-Reviewed Original Research
2009
Pain site frequency and location in sickle cell disease: The PiSCES project
McClish DK, Smith WR, Dahman BA, Levenson JL, Roberts JD, Penberthy LT, Aisiku IP, Roseff SD, Bovbjerg VE. Pain site frequency and location in sickle cell disease: The PiSCES project. Pain 2009, 145: 246-251. PMID: 19631468, PMCID: PMC2771372, DOI: 10.1016/j.pain.2009.06.029.Peer-Reviewed Original ResearchConceptsPain locationPain daysPain sitesBody chartSickle Cell Disease PainFrequency of painDaily pain diarySickle cell diseasePiSCES projectPain crisisDisease painED utilizationPain diaryFrequent painHealthcare utilizationEpidemiologic descriptionTreatment optionsLower extremitiesCell diseaseUpper backPainSCD managementUnplanned utilizationSixty subjectsUnderstanding of combinations
2008
Comparisons of High Versus Low Emergency Department Utilizers in Sickle Cell Disease
Aisiku IP, Smith WR, McClish DK, Levenson JL, Penberthy LT, Roseff SD, Bovbjerg VE, Roberts JD. Comparisons of High Versus Low Emergency Department Utilizers in Sickle Cell Disease. Annals Of Emergency Medicine 2008, 53: 587-593. PMID: 18926599, DOI: 10.1016/j.annemergmed.2008.07.050.Peer-Reviewed Original ResearchConceptsSickle cell disease patientsHigh ED utilizersSickle cell diseaseDisease patientsEmergency departmentCell diseaseQuality of lifeFrequency of painSickle cell painDescriptors of painBaseline dataLower hematocrit levelsHealth dataPain daysMore transfusionsPain characteristicsPain crisisED utilizationLaboratory variablesHigh utilizersMore painPainHematocrit levelsPatientsSummary scales