Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo
Hamed H, Hawkins W, Mitchell C, Gilfor D, Zhang G, Pei XY, Dai Y, Hagan MP, Roberts JD, Yacoub A, Grant S, Dent P. Transient exposure of carcinoma cells to RAS/MEK inhibitors and UCN-01 causes cell death in vitro and in vivo. Molecular Cancer Therapeutics 2008, 7: 616-629. PMID: 18347148, DOI: 10.1158/1535-7163.mct-07-2376.Peer-Reviewed Original ResearchMeSH KeywordsBlotting, WesternCell DeathCell Line, TumorElectrophoresis, Polyacrylamide GelHumansImmunohistochemistryMAP Kinase Kinase 1Protein Kinase InhibitorsStaurosporineConceptsMammary carcinoma cellsCarcinoma cellsMammary tumorsTumor growthUCN-01Tumor cellsMEK1/2 inhibitor PD184352MEK1/2 inhibitorMammary tumor growthMean tumor volumeTransient exposureTumor growth rateHuman mammary carcinoma cellsColony formation assaysExpression of BaxColony formation studiesMEK1/2 inhibitor treatmentFarnesyl transferase inhibitorsCell tumorsDrug exposureDrug treatmentTumor volumeAthymic miceDrug AdministrationInhibitor treatment