2018
Sa1180 - Activation of the Calcium Sensing Receptor (Casr) Leads to Enhanced Fluid and Electrolyte Absorption in the Rat Small Intestine
Lysyy T, Caturegli G, Finotti M, Maina R, Barahona M, D'Amico F, Mulligan D, Geibel J. Sa1180 - Activation of the Calcium Sensing Receptor (Casr) Leads to Enhanced Fluid and Electrolyte Absorption in the Rat Small Intestine. Gastroenterology 2018, 154: s-269-s-270. DOI: 10.1016/s0016-5085(18)31261-7.Peer-Reviewed Original ResearchCalcium sensing receptorRat small intestineSmall intestineSensing receptorElectrolyte absorptionIntestineModulations in extracellular calcium lead to H+-ATPase-dependent acid secretion: a clarification of PPI failure
Kitay AM, Schneebacher MT, Schmitt A, Heschl K, Kopic S, Alfadda T, Alsaihati A, Link A, Geibel J. Modulations in extracellular calcium lead to H+-ATPase-dependent acid secretion: a clarification of PPI failure. AJP Gastrointestinal And Liver Physiology 2018, 315: g36-g42. PMID: 29517927, DOI: 10.1152/ajpgi.00132.2017.Peer-Reviewed Original ResearchConceptsAcid secretionParietal cellsExtracellular calciumGastric parietal cellsProton pump inhibitor exposureExtracellular CaPotassium-free conditionsRecurrent reflux symptomsCalcium sensing receptorGastric acid secretionPPI failurePPI therapyReflux symptomsIsolated gastric glandsInhibitor exposureCalcimimetic R568Pharmacological targetsSensing receptorAbsence of sodiumCalcium concentrationCaSRGastric glandsSecretionATPase activityExcretion pathway
2017
Chapter 2 Molecular Aspects of the Calcium-Sensing Receptor and Calcium Homeostasis
Alkukhun A, Munoz-Abraham A, Judeeba S, Geibel J. Chapter 2 Molecular Aspects of the Calcium-Sensing Receptor and Calcium Homeostasis. 2017, 15-26. DOI: 10.1016/b978-0-12-802168-2.00002-6.ChaptersCalcium homeostasisImmune barrier functionCalcium sensing receptorGastric acid secretionCalcium-sensing receptorExtracellular calcium levelsVitamin DAntidiarrheal effectBile flowHormone secretionParathyroid glandsImmune responseGastrointestinal tractAcid secretionIntestinal floraElectrolyte balanceCalcium levelsBone mineralizationBarrier functionCaSROsteoclast proliferationKey modulatorReceptorsSecretionPhysiological functions
2013
The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule
Capasso G, Geibel PJ, Damiano S, Jaeger P, Richards WG, Geibel JP. The calcium sensing receptor modulates fluid reabsorption and acid secretion in the proximal tubule. Kidney International 2013, 84: 277-284. PMID: 23615500, DOI: 10.1038/ki.2013.137.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAnimalsCalcimimetic AgentsCalciumHydrogen-Ion ConcentrationIn Vitro TechniquesKidney Tubules, ProximalMaleMiceMice, KnockoutNuclear ProteinsPerfusionPuncturesRatsRats, Sprague-DawleyReceptors, Calcium-SensingReceptors, G-Protein-CoupledSodium-Hydrogen ExchangersTranscription FactorsConceptsProximal tubulesLuminal calcium concentrationFluid reabsorptionAcid secretionKnockout miceCalcium ion concentrationCalcium concentrationRole of CaSRActivation of CaSRCalcium sensing receptorCalcium-sensing receptorMouse proximal tubulesProton secretionSodium-hydrogen exchangerCalcimimetic agentBicarbonate absorptionSensing receptorCaSRFluid absorptionSecretionReabsorptionMiceCalcimimeticsTubulesLuminal membraneChapter 63 The Calcium-Sensing Receptor
Brown E, Hebert S, Riccardi D, Geibel J. Chapter 63 The Calcium-Sensing Receptor. 2013, 2187-2224. DOI: 10.1016/b978-0-12-381462-3.00063-x.Peer-Reviewed Original ResearchIon homeostasisMineral ion homeostasisCell surface sensorsDiverse physiological processesG protein-coupled receptorsCalcium sensing receptorPrimary physiological ligandProtein-coupled receptorsCellular processesExtracellular calcium-sensing receptorAromatic amino acidsAquatic animalsBiological roleWhole organismPhysiological processesFirst messengersPhysiological ligandsPhospholipase CAmino acidsCalcium-sensing receptorHomeostatic processesCalciostatHomeostasisAutosomal dominant hypocalcemiaExtracellular Ca2
2010
M1681 Calcium-Sensing Receptor and AMP-Activated Protein Kinase Regulated Acid Secretion in the Parietal Cell
Greenstein A, Boroumand M, Geibel P, Geibel J. M1681 Calcium-Sensing Receptor and AMP-Activated Protein Kinase Regulated Acid Secretion in the Parietal Cell. Gastroenterology 2010, 138: s-397. DOI: 10.1016/s0016-5085(10)61824-0.Peer-Reviewed Original Research
2009
S2062 Reversal of Osmotic Diarrhea Through Activation of the Rat Ileal Calcium Sensing Receptor (CaSR)
Ballwieser D, Joseph R, Sauter M, Geibel J. S2062 Reversal of Osmotic Diarrhea Through Activation of the Rat Ileal Calcium Sensing Receptor (CaSR). Gastroenterology 2009, 136: a-322-a-323. DOI: 10.1016/s0016-5085(09)61477-3.Peer-Reviewed Original Research