2000
Cell pH and H+ Secretion by S3 Segment of Mammalian Kidney: Role of H+-ATPase and Cl−
Malnic G, Geibel J. Cell pH and H+ Secretion by S3 Segment of Mammalian Kidney: Role of H+-ATPase and Cl−. The Journal Of Membrane Biology 2000, 178: 115-125. PMID: 11083900, DOI: 10.1007/s002320010019.Peer-Reviewed Original ResearchConceptsProximal tubule cellsChannel blocker NPPBS3 segmentTubule cellsProximal S3 segmentsFree mediumCell pHConfocal microscopyNIH Image programCell pH regulationMicroperfusion techniqueSuperfusionMouse kidneyRabbit kidneyKidneySubcellular vesiclesApical areaCell acidificationMammalian kidneyFluorescence densityNPPBRingerCellsImage programNaCl Ringer
1998
Angiotensin II stimulates vesicular H+-ATPase in rat proximal tubular cells
Wagner C, Giebisch G, Lang F, Geibel J. Angiotensin II stimulates vesicular H+-ATPase in rat proximal tubular cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 9665-9668. PMID: 9689138, PMCID: PMC21396, DOI: 10.1073/pnas.95.16.9665.Peer-Reviewed Original ResearchConceptsAngiotensin IIProximal tubulesIon secretionEffect of AIIRat proximal tubular cellsAngiotensin II stimulatesRemoval of ClPH-sensitive fluorescent dye 2Proximal tubular cellsNa/H exchangerBafilomycin A1Proximal tubule fragmentsTubular cellsBicarbonate reabsorptionHCO3- reabsorptionTubule fragmentsH exchangerATPase activityFluorescent dye 2Proton pump inhibitor bafilomycin A1Intracellular pHTubulesSecretionPresent studyCell pH
1997
Intracellular Acidification Induces Cl/HCO3 Exchange Activity in the Basolateral Membrane of β-intercalated Cells of the Rabbit Cortical Collecting Duct
Merot J, Giebisch G, Geibel J. Intracellular Acidification Induces Cl/HCO3 Exchange Activity in the Basolateral Membrane of β-intercalated Cells of the Rabbit Cortical Collecting Duct. The Journal Of Membrane Biology 1997, 159: 253-262. PMID: 9312214, DOI: 10.1007/s002329900288.Peer-Reviewed Original ResearchConceptsBeta-intercalated cellsCortical collecting ductsRabbit cortical collecting ductsHCO3- exchange activityAcid-base transportersProfound decreaseChloride-bicarbonate exchangerCollecting ductsBasolateral additionBasolateral DIDSPH recoveryApical applicationIntracellular pHCell pHDifferent lag periodsBasolateral membraneCellsDuctAcid loading