1993
Mechanism of apical K+ channel modulation in principal renal tubule cells. Effect of inhibition of basolateral Na(+)-K(+)-ATPase.
Wang W, Geibel J, Giebisch G. Mechanism of apical K+ channel modulation in principal renal tubule cells. Effect of inhibition of basolateral Na(+)-K(+)-ATPase. The Journal Of General Physiology 1993, 101: 673-694. PMID: 8393065, PMCID: PMC2216783, DOI: 10.1085/jgp.101.5.673.Peer-Reviewed Original ResearchConceptsEffect of inhibitionPump inhibitionInhibitory effectChannel activityProtein kinase CPump activityAddition of strophanthidinPatch-clamp techniqueRenal tubule cellsBath solutionCell-attached patchesExtracellular Ca2Removal of Ca2Intracellular Ca2MicroM ionomycinTubule cellsControl valuesLow-conductance K channelsPrincipal cellsChannel modulationK channelsInhibitionNM staurosporineDependent protein kinase CPotent inhibitorMechanism of activation of K++ channels by minoxidil-sulfate in Madin-Darby canine kidney cells
Schwab A, Geibel J, Wang W, Oberleithner H, Giebisch G. Mechanism of activation of K++ channels by minoxidil-sulfate in Madin-Darby canine kidney cells. The Journal Of Membrane Biology 1993, 132: 125-136. PMID: 8496944, DOI: 10.1007/bf00239002.Peer-Reviewed Original Research
1990
A potassium channel in the apical membrane of rabbit thick ascending limb of Henle's loop
Wang W, White S, Geibel J, Giebisch G. A potassium channel in the apical membrane of rabbit thick ascending limb of Henle's loop. American Journal Of Physiology 1990, 258: f244-f253. PMID: 2309888, DOI: 10.1152/ajprenal.1990.258.2.f244.Peer-Reviewed Original ResearchConceptsCell-attached patchesHenle's loopPipette solutionPotassium channelsOutward slope conductanceRabbit kidneyBath solutionSlope conductanceThick ascending limbChannel activityPatch-clamp techniqueInward slope conductanceApical membraneVoltage-dependent mannerAscending limbSingle potassium channelsKidneyPossible intracellular regulatorsIntracellular regulatorsOpen probabilityLimb