Mechanism of apical K+ channel modulation in principal renal tubule cells. Effect of inhibition of basolateral Na(+)-K(+)-ATPase.
Wang W, Geibel J, Giebisch G. Mechanism of apical K+ channel modulation in principal renal tubule cells. Effect of inhibition of basolateral Na(+)-K(+)-ATPase. The Journal Of General Physiology 1993, 101: 673-694. PMID: 8393065, PMCID: PMC2216783, DOI: 10.1085/jgp.101.5.673.Peer-Reviewed Original ResearchConceptsEffect of inhibitionPump inhibitionInhibitory effectChannel activityProtein kinase CPump activityAddition of strophanthidinPatch-clamp techniqueRenal tubule cellsBath solutionCell-attached patchesExtracellular Ca2Removal of Ca2Intracellular Ca2MicroM ionomycinTubule cellsControl valuesLow-conductance K channelsPrincipal cellsChannel modulationK channelsInhibitionNM staurosporineDependent protein kinase CPotent inhibitor