2001
Cloning and Expression of a Chloride-dependent Na+-H+ Exchanger*
Sangan P, Rajendran VM, Geibel JP, Binder HJ. Cloning and Expression of a Chloride-dependent Na+-H+ Exchanger*. Journal Of Biological Chemistry 2001, 277: 9668-9675. PMID: 11773056, DOI: 10.1074/jbc.m110852200.Peer-Reviewed Original ResearchMeSH KeywordsAmilorideAmino Acid SequenceAnimalsBlotting, NorthernCell LineChlorineCloning, MolecularColonDiureticsDNA, ComplementaryFibroblastsHydrogen-Ion ConcentrationIn Situ HybridizationMaleMolecular Sequence DataPhosphorylationProtein Structure, TertiaryRatsRats, Sprague-DawleyRNA, MessengerSequence Homology, Amino AcidSodiumSodium-Hydrogen Exchanger 1Sodium-Hydrogen ExchangersTime FactorsTissue DistributionConceptsRat distal colonDistal colonAmino acidsCrypt cellsExchange isoformsDietary sodium depletionColonic crypt cellsFull-length cDNACl- channel blockerColonic epithelial cellsN-terminal regionNorthern blot analysisSodium depletionChannel blockersNovel C-terminusPutative transmembranePS120 fibroblastsAcid loadDependent intracellularC-terminusNHE-1Epithelial cellsIsoform inhibitorAmiloride analoguesMultiple tissues
1998
Differential localization of colonic H+-K+-ATPase isoforms in surface and crypt cells
Rajendran V, Singh S, Geibel J, Binder H. Differential localization of colonic H+-K+-ATPase isoforms in surface and crypt cells. American Journal Of Physiology 1998, 274: g424-g429. PMID: 9486199, DOI: 10.1152/ajpgi.1998.274.2.g424.Peer-Reviewed Original ResearchConceptsCrypt cellsColonic cryptsRat distal colonSurface cellsSurface epithelial cellsATPase isoformsOuabain-insensitive componentApical membraneDistal colonAcid loadDependent intracellularEpithelial cellsATPase activityCryptsDifferential localizationOuabainATPase alpha subunitCellsAlpha subunitCompelling evidenceIsoformsColonActivityRecovery