2002
Calcium-pump inhibitors induce functional surface expression of ΔF508-CFTR protein in cystic fibrosis epithelial cells
Egan ME, Glöckner-Pagel J, Ambrose C, Cahill PA, Pappoe L, Balamuth N, Cho E, Canny S, Wagner CA, Geibel J, Caplan MJ. Calcium-pump inhibitors induce functional surface expression of ΔF508-CFTR protein in cystic fibrosis epithelial cells. Nature Medicine 2002, 8: 485-492. PMID: 11984593, DOI: 10.1038/nm0502-485.Peer-Reviewed Original ResearchConceptsEndoplasmic reticulumCalcium pump inhibitorΔF508-CFTR proteinCystic fibrosis epithelial cellsCystic fibrosis transmembrane conductance regulator (CFTR) proteinCystic fibrosis cell lineFunctional surface expressionSurface expressionChaperone activityChaperone proteinsRegulator proteinPlasma membraneCystic fibrosis defectCell surfaceProteinCell linesPotential targetOptimal activityInhibitor thapsigarginEpithelial cellsExpressionCommon mutationsInhibitorsMouse modelReticulum
2000
Calcium, ATP and nuclear pore channel gating
Bustamante J, Michelette E, Geibel J, Dean D, Hanover J, McDonnell T. Calcium, ATP and nuclear pore channel gating. Pflügers Archiv - European Journal Of Physiology 2000, 439: 433-444. PMID: 10678739, PMCID: PMC4400178, DOI: 10.1007/s004249900189.Peer-Reviewed Original ResearchMeSH KeywordsAdenosine TriphosphateAnimalsAntibodies, MonoclonalBiological TransportCalciumCalcium ChannelsChelating AgentsCytosolDextransEgtazic AcidEndoplasmic ReticulumEnzyme InhibitorsFluorescein-5-isothiocyanateFluorescent DyesGene Expression Regulation, NeoplasticInositol 1,4,5-TrisphosphateIon Channel GatingMaleNuclear EnvelopeOocytesPatch-Clamp TechniquesProstatic NeoplasmsThapsigarginTumor Cells, CulturedXenopus laevisConceptsNPC channelGene activityChannel gatingMacromolecular transportCytosolic Ca2Fluorescence microscopy observationsTranscription factorsNE membranesProstate cancer cellsCytosolic ATPIntracellular messengerCellular rhythmsRole of Ca2ATPCancer cellsPatch-clamp studiesPresent patch-clamp studyRNAIon channel behaviorRegulationCardiomyocyte nucleiGatingExpressionCa2Thapsigargin