2006
Hypertonic Saline Attenuates Colonic Tumor Cell Metastatic Potential by Activating Transmembrane Sodium Conductance
Shields CJ, Winter DC, Geibel JP, O’Sullivan G, Wang JH, Redmond HP. Hypertonic Saline Attenuates Colonic Tumor Cell Metastatic Potential by Activating Transmembrane Sodium Conductance. The Journal Of Membrane Biology 2006, 211: 35-42. PMID: 16988862, DOI: 10.1007/s00232-006-0011-8.Peer-Reviewed Original ResearchConceptsHypertonic salineSodium-hydrogen exchangeIntegrin expressionIntracellular sodiumMetastatic potentialHuman colonic tumor cellsAdhesion molecule expressionSodium concentrationColonic tumor cellsTumor cell metastatic potentialIntracellular pHCell metastatic potentialCytosolic sodium concentrationMolecule expressionΒ1 integrin expressionHyperosmolar solutionsConfocal laser microscopic imagingEffect of hypertonicityTumor cellsInhibitory effectSodium responseHypertonic exposureCellular alkalinizationTumor cell-endothelial interactionsSodium conductance
1998
Angiotensin II stimulates vesicular H+-ATPase in rat proximal tubular cells
Wagner C, Giebisch G, Lang F, Geibel J. Angiotensin II stimulates vesicular H+-ATPase in rat proximal tubular cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 9665-9668. PMID: 9689138, PMCID: PMC21396, DOI: 10.1073/pnas.95.16.9665.Peer-Reviewed Original ResearchConceptsAngiotensin IIProximal tubulesIon secretionEffect of AIIRat proximal tubular cellsAngiotensin II stimulatesRemoval of ClPH-sensitive fluorescent dye 2Proximal tubular cellsNa/H exchangerBafilomycin A1Proximal tubule fragmentsTubular cellsBicarbonate reabsorptionHCO3- reabsorptionTubule fragmentsH exchangerATPase activityFluorescent dye 2Proton pump inhibitor bafilomycin A1Intracellular pHTubulesSecretionPresent studyCell pH
1997
RAPID ALDOSTERONE‐INDUCED CELL VOLUME INCREASE OF ENDOTHELIAL CELLS MEASURED BY THE ATOMIC FORCE MICROSCOPE
SCHNEIDER S, YANO Y, SUMPIO B, JENA B, GEIBEL J, GEKLE M, OBERLEITHNER H. RAPID ALDOSTERONE‐INDUCED CELL VOLUME INCREASE OF ENDOTHELIAL CELLS MEASURED BY THE ATOMIC FORCE MICROSCOPE. Cell Biology International 1997, 21: 759-768. PMID: 9768474, DOI: 10.1006/cbir.1997.0220.Peer-Reviewed Original ResearchConceptsEndothelial cellsAddition of aldosteroneArterial blood pressureNon-genomic effectsCultured endothelial cellsBlood pressureMineralocorticoid hormonesHormone exposureAldosteroneCell volumeHuman leukocytesIntracellular electrolytesTransient swellingTriphosphate productionIntracellular pHLeukocytesVolume increaseBovine aortaContinuous presenceCellsPlasma membraneIntracellular Acidification Induces Cl/HCO3 Exchange Activity in the Basolateral Membrane of β-intercalated Cells of the Rabbit Cortical Collecting Duct
Merot J, Giebisch G, Geibel J. Intracellular Acidification Induces Cl/HCO3 Exchange Activity in the Basolateral Membrane of β-intercalated Cells of the Rabbit Cortical Collecting Duct. The Journal Of Membrane Biology 1997, 159: 253-262. PMID: 9312214, DOI: 10.1007/s002329900288.Peer-Reviewed Original ResearchConceptsBeta-intercalated cellsCortical collecting ductsRabbit cortical collecting ductsHCO3- exchange activityAcid-base transportersProfound decreaseChloride-bicarbonate exchangerCollecting ductsBasolateral additionBasolateral DIDSPH recoveryApical applicationIntracellular pHCell pHDifferent lag periodsBasolateral membraneCellsDuctAcid loading