2018
Activation of the Calcium Sensing Receptor (casr) Prevents Secretagogue-Induced Diarrhea in the Rat Small Intestine
Finotti M, Lysyy T, Caturegli G, Barahona M, Maina R, D'Amico F, Mulligan D, Geibel J. Activation of the Calcium Sensing Receptor (casr) Prevents Secretagogue-Induced Diarrhea in the Rat Small Intestine. Transplantation 2018, 102: s669. DOI: 10.1097/01.tp.0000543607.00911.f4.Peer-Reviewed Original ResearchOral rehydration solutionSmall intestineColon segmentsIntestinal secretionNumerous body tissuesSeverity of diarrheaDistal small intestineMale Sprague-DawleyCalcium-sensing receptorDistal portionLuminal calcium concentrationRat small intestineAbsence of forskolinCalcium perfusionProphylactic therapyAntibiotic therapyLeading causePotent secretagogueRehydration solutionSprague-DawleyElectrolyte homeostasisDiarrheaPotential treatmentSecretion profileAbsorption of fluidGenerating vascular conduits: from tissue engineering to three-dimensional bioprinting
Maina RM, Barahona MJ, Finotti M, Lysyy T, Geibel P, D’Amico F, Mulligan D, Geibel JP. Generating vascular conduits: from tissue engineering to three-dimensional bioprinting. Innovative Surgical Sciences 2018, 3: 203-213. PMID: 31579784, PMCID: PMC6604577, DOI: 10.1515/iss-2018-0016.Peer-Reviewed Original ResearchArtery diseaseVascular conduitsVascular diseaseAutologous graftsNative vesselsSuitable vascular conduitInternal mammary arteryPeripheral vascular diseaseRat vascular smooth muscle cellsThird of patientsCoronary artery diseaseCarotid artery diseaseVascular smooth muscle cellsStandard of careLimb-saving procedureSmooth muscle cellsMultivessel diseaseDonor graftsMammary arteryPoor outcomeSaphenous veinLeading causeVascular interventionsGraftMuscle cells
2017
Acute Effects of Vitamin C Exposure On Colonic Crypts: Direct Modulation of pH Regulation
Aldajani MM, Vanicek CN, Alhazzaa N, Lysyy T, Agarwal R, Geibel JP. Acute Effects of Vitamin C Exposure On Colonic Crypts: Direct Modulation of pH Regulation. Cellular Physiology And Biochemistry 2017, 44: 377-387. PMID: 29132138, DOI: 10.1159/000484914.Peer-Reviewed Original ResearchConceptsVitamin CColonic cryptsAcute effectsDependent intracellular pH recoveryTumor formationIntracellular pH recoveryNew therapeutic agentsMM vitamin CColorectal cancerDistal colonLeading causeTranscellular passive diffusionBasolateral membraneAcute additionNormal colonic cryptsC exposureNutraceutical agentTherapeutic agentsPH recoveryIntracellular pH changesCancer cellsVitamin C.CryptsLow intracellularTight junctions
2016
Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells
Ferstl FS, Kitay AM, Trattnig RM, Alsaihati A, Geibel JP. Secretagogue-dependent and -independent transport of zinc hydration forms in rat parietal cells. Pflügers Archiv - European Journal Of Physiology 2016, 468: 1877-1883. PMID: 27757581, DOI: 10.1007/s00424-016-1889-3.Peer-Reviewed Original ResearchConceptsGastroesophageal reflux diseaseAcid secretionParietal cellsSecretagogue-stimulated acid secretionRecurrence of symptomsAlternative treatment optionNumber of patientsNon-fasted conditionsApplication of bumetanideEffects of secretagoguesRat parietal cellsReflux diseaseInhibitor therapyTreatment optionsNon-fasted animalsLeading causeNeuronal activationNKCC1 transporterNeuronal pathwaysGastric acidInhibitor bumetanideSecretagogue carbacholFasted animalsMechanism of entryHormonal activation