2012
Effect of the AMP-Kinase Modulators AICAR, Metformin and Compound C on Insulin Secretion of INS-1E Rat Insulinoma Cells under Standard Cell Culture Conditions
Langelueddecke C, Jakab M, Ketterl N, Lehner L, Hufnagl C, Schmidt S, Geibel JP, Fuerst J, Ritter M. Effect of the AMP-Kinase Modulators AICAR, Metformin and Compound C on Insulin Secretion of INS-1E Rat Insulinoma Cells under Standard Cell Culture Conditions. Cellular Physiology And Biochemistry 2012, 29: 75-86. PMID: 22415077, DOI: 10.1159/000337589.Peer-Reviewed Original ResearchConceptsAMP-dependent protein kinaseCompound CStandard cell culture conditionsCell culture conditionsINS-1E rat insulinoma cellsAMPK phosphorylationAMPK inhibitor compound CCulture conditionsCell membrane potentialAMPK-independent mechanismCell metabolic stateInhibitor compound CINS-1E cellsMetabolic stateMembrane potentialStimulus-secretion couplingBasal AMPK phosphorylationΒ-cell survivalCell cycle arrestProtein kinaseΒ-cell line INS-1E.Nutrient uptakeAMPK activatorCell cycle distributionInsulin secretion
2005
Fluorescent imaging of Cl- in Amphiuma red blood cells: How the nuclear exclusion of Cl- affects the plasma membrane potential
Hoffman JF, Geibel JP. Fluorescent imaging of Cl- in Amphiuma red blood cells: How the nuclear exclusion of Cl- affects the plasma membrane potential. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 921-926. PMID: 15637151, PMCID: PMC545567, DOI: 10.1073/pnas.0408597102.Peer-Reviewed Original ResearchConceptsPlasma membrane potentialMembrane potentialExclusion of ClNuclear exclusionCytoplasmic compartmentCellular ClAmphiuma red blood cellsCytoplasmNet negative chargeValues of EmCellsIntracellular ClRed blood cellsBlood cellsCell ClDistribution of ClFluorescent imagingEquilibrium distributionDNANucleusFluorescence intensitySensitive dyeCompartmentsRed cellsNegative charge
1993
Imaging the lamellipodium of migrating epithelial cells in vivo by atomic force microscopy
Oberleithner H, Giebisch G, Geibel J. Imaging the lamellipodium of migrating epithelial cells in vivo by atomic force microscopy. Pflügers Archiv - European Journal Of Physiology 1993, 425: 506-510. PMID: 8134267, DOI: 10.1007/bf00374878.Peer-Reviewed Original ResearchConceptsPlasma membraneCell locomotionNew plasma membraneCell surfacePlasma membrane potentialCanine kidney cell linePlasma membrane integrityMadin-Darby canine kidney (MDCK) cell lineDynamic physiological processesKidney cell lineAlkaline stressInvagination processCytoskeletal elementsMDCK-F cellsPhysiological processesMembrane integrityMembrane turnoverCell linesKidney cellsMembrane potentialEpithelial cellsTurnover processCellsMembranePotential role